WormBase Tree Display for Gene: WBGene00003877

WBGene00003877 SMap: S_parent: Sequence: K04E7
  Identity: Version: 2
    Name: CGC_name: pept-1 Person_evidence: WBPerson2603
            WBPerson861
      Sequence_name: K04E7.2
      Molecular_name: K04E7.2
        K04E7.2.1
        CE25039
      Other_name: pep-2
        opt-2
        CELE_K04E7.2 Accession_evidence: NDB BX284606
      Public_name: pept-1
    DB_info: Database: AceView gene XH79
        WormQTL gene WBGene00003877
        WormFlux gene WBGene00003877
        NDB locus_tag CELE_K04E7.2
        Panther gene CAEEL|WormBase=WBGene00003877|UniProtKB=Q21219
          family PTHR11654
        NCBI gene 180919
        RefSeq protein NM_076686.7
        SwissProt UniProtAcc Q21219
        UniProt_GCRP UniProtAcc Q21219
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Apr 2009 13:55:02 WBPerson9133 Name_change: CGC_name: pept-1
                Other_name: opt-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pept
    Allele (85)
    Possibly_affected_by: WBVar02157263
    Strain: WBStrain00036075
      WBStrain00003894
    RNASeq_FPKM (74)
    GO_annotation (46)
    Ortholog (46)
    Paralog: WBGene00003876 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003878 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: pept-1 encodes a low affinity/high capacity oligopeptide transporter; pept-1 is required for uptake of intact peptides from the intestine and thus for normal development, growth, and reproduction; genetic studies indicate that pept-1 interacts with both the daf-2/insulin- and let-363/TOR-signaling pathways to regulate lifespan and with the daf-2 pathway to influence stress response; PEPT-1 is expressed in the intestine where it localizes to the apical membrane. Paper_evidence: WBPaper00006186
            WBPaper00024423
          Curator_confirmed: WBPerson1843
          Date_last_updated: 05 Nov 2009 00:00:00
      Automated_description: Enables dipeptide transmembrane transporter activity. Involved in several processes, including chemical homeostasis; nitrogen compound transport; and regulation of signal transduction. Located in apical plasma membrane. Expressed in intestine. Used to study obesity. Is an ortholog of human SLC15A1 (solute carrier family 15 member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00034742
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Sep 2021 00:00:00
  Models_disease_asserted: WBDOannot00000178
  Molecular_info: Corresponding_CDS: K04E7.2
    Corresponding_transcript: K04E7.2.1
    Other_sequence (23)
    Associated_feature: WBsf662881
      WBsf978975
      WBsf1005576
      WBsf1023101
      WBsf235837
  Experimental_info: RNAi_result (49)
    Expr_pattern: Expr1421
      Expr8048
      Expr8049
      Expr10732
      Expr1026620
      Expr1031825
      Expr1153607
      Expr2014823
      Expr2033057
      Marker28
    Drives_construct (23)
    Construct_product: WBCnstr00004990
      WBCnstr00009194
      WBCnstr00013078
      WBCnstr00014892
      WBCnstr00016252
      WBCnstr00018325
      WBCnstr00037949
    Regulate_expr_cluster: WBPaper00045460:Co-expression_Cluster_1
      WBPaper00045460:Co-expression_Cluster_2
      WBPaper00045460:Co-expression_Cluster_3
      WBPaper00045460:pept-1(lg601)_downregulated
      WBPaper00045460:pept-1(lg601)_upregulated
    Antibody: WBAntibody00002276
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044005:DAF-16_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00045918:96h_infection_recovery_downregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048810:CoQ-deficiency_downregulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053094:adr-2(ok735)_neuron_downregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054192:cold-shock_downregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056039:ptl-1(ok621)_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056218:daf-16(mu86)_downregulated_Day5
      WBPaper00056218:daf-16(mu86)_downregulated_Day7
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059253:stearic-acid_downregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059598:HeatShock_downregulated
      WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_upregulated_N2
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_downregulated_AFD
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065392:Lb.plantarum_upregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock-With-Recovery_downregulated_N2
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_2_4
      cgc4489_group_3
      WBPaper00006465:IV_ethanol_late_repression
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:FedUp
      WBPaper00033101:spr-5_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_G
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039792:TempShiftIncrease
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00044091:Bpseudomallei_repressed_4h
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00050538:Fasting_upregulated_cholesterol-dependent
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00053688:E.faecium_downregulated
      WBPaper00055435:MUA-AuNP-3_upregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5976]:class_2
      [cgc6390]:Cluster_C
      [cgc6390]:herm_soma-enriched
    Interaction (114)
  Map_info: Map: X Position: -2.89742 Error: 0.002559
    Positive: Positive_clone: K04E7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (57)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene