WormBase Tree Display for Gene: WBGene00013308

WBGene00013308 SMap: S_parent: Sequence: Y57G11C
  Identity: Version: 4
    Name: CGC_name: nuo-3 Person_evidence: WBPerson1157
      Sequence_name: Y57G11C.12
      Molecular_name: Y57G11C.12
        Y57G11C.12.1
        CE14948
        Y57G11C.12.2
      Other_name: ndua-6 Person_evidence: WBPerson555
        CELE_Y57G11C.12 Accession_evidence: NDB BX284604
      Public_name: nuo-3
    DB_info: Database: WormQTL gene WBGene00013308
        WormFlux gene WBGene00013308
        NDB locus_tag CELE_Y57G11C.12
        Panther gene CAEEL|WormBase=WBGene00013308|UniProtKB=O18236
          family PTHR12964
        NCBI gene 36805062
        RefSeq protein NM_001392444.1
        TrEMBL UniProtAcc O18236
        UniProt_GCRP UniProtAcc O18236
        OMIM gene 602138
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 31 Aug 2005 14:07:05 WBPerson2970 Name_change: CGC_name: nuo-3
        3 06 Mar 2018 14:43:22 WBPerson4025 Event: Split_into: WBGene00303007
        4 16 Jan 2023 18:37:21 WBPerson51134 Name_change: Other_name: ndua-6
      Split_into: WBGene00303007
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nuo
    Allele (27)
    Strain: WBStrain00003089
      WBStrain00055406
    RNASeq_FPKM (74)
    GO_annotation: 00031815
      00031816
      00031817
      00031818
      00031819
      00031820
      00031821
      00031822
      00031823
    Contained_in_operon: CEOP5614
    Ortholog (28)
    Structured_description: Concise_description: The nuo-3 locus encodes two distinct, non-overlapping proteins: Y57G11C.12a (homologous to human C3orf10/BRICK1, a component of the WAVE1 complex) and Y57G11C.12b (a putativeNADH-ubiquinone oxidoreductase alpha subunit, homologous to human NDUFA6 [OMIM:602138]). Person_evidence: WBPerson242
          Curator_confirmed: WBPerson567
          Date_last_updated: 12 May 2008 00:00:00
      Automated_description: Predicted to be involved in response to oxidative stress. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Alzheimer's disease and nuclear type mitochondrial complex I deficiency 33. Is an ortholog of human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112097 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7690)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7690)
  Molecular_info: Corresponding_CDS: Y57G11C.12
    Corresponding_CDS_history: Y57G11C.12a:wp264
      Y57G11C.12b:wp264
    Corresponding_transcript: Y57G11C.12.1
      Y57G11C.12.2
    Corresponding_transcript_history: Y57G11C.12c:wp264
    Associated_feature: WBsf652383
      WBsf981851
      WBsf998642
      WBsf231227
  Experimental_info: RNAi_result (35)
    Expr_pattern: Chronogram977
      Expr7077
      Expr1012642
      Expr1035936
      Expr1161096
      Expr2014529
      Expr2032768
    Drives_construct: WBCnstr00003574
      WBCnstr00029696
    Construct_product: WBCnstr00029696
    Microarray_results (32)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00032528:L3_enriched
      WBPaper00035073:mitochondria_protein
      WBPaper00037086:biotin_regulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056900:PID-3_interacting
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059254:CSR-1_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060911:prx-5(RNAi)_downregulated_protein
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061527:B0495.9-ZK1128.1
      WBPaper00061527:dld-1-skn-1_16701
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      cgc4386_cluster_1_5
      WBPaper00025032:cluster_152
      WBPaper00025032:cluster_157
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_H
      WBPaper00037147:heatshock_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      [cgc5767]:cluster_29
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(66_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction: WBInteraction000032336
      WBInteraction000049555
      WBInteraction000111671
      WBInteraction000111679
      WBInteraction000111685
      WBInteraction000111689
      WBInteraction000111692
      WBInteraction000111693
      WBInteraction000111703
      WBInteraction000111713
      WBInteraction000111722
      WBInteraction000111774
      WBInteraction000144478
      WBInteraction000153356
      WBInteraction000153386
      WBInteraction000153411
      WBInteraction000153441
      WBInteraction000153477
      WBInteraction000153504
      WBInteraction000153618
      WBInteraction000153663
      WBInteraction000154088
      WBInteraction000154179
      WBInteraction000155252
      WBInteraction000155512
      WBInteraction000155540
      WBInteraction000155604
      WBInteraction000155667
      WBInteraction000155699
      WBInteraction000155739
      WBInteraction000155796
      WBInteraction000155797
      WBInteraction000155798
      WBInteraction000155799
      WBInteraction000155835
      WBInteraction000155975
      WBInteraction000156157
      WBInteraction000156308
      WBInteraction000156373
      WBInteraction000156391
      WBInteraction000156423
      WBInteraction000156437
      WBInteraction000156456
      WBInteraction000157397
      WBInteraction000157417
      WBInteraction000157433
      WBInteraction000157447
      WBInteraction000157473
      WBInteraction000157485
      WBInteraction000157505
      WBInteraction000157515
      WBInteraction000157561
      WBInteraction000157572
      WBInteraction000157580
      WBInteraction000157589
      WBInteraction000157596
      WBInteraction000157602
      WBInteraction000184236
      WBInteraction000193778
      WBInteraction000198356
      WBInteraction000204271
      WBInteraction000218873
      WBInteraction000222592
      WBInteraction000247974
      WBInteraction000252907
      WBInteraction000299025
      WBInteraction000319471
      WBInteraction000325720
      WBInteraction000372583
      WBInteraction000380822
      WBInteraction000386930
      WBInteraction000392455
      WBInteraction000416486
      WBInteraction000438541
      WBInteraction000439227
      WBInteraction000444983
      WBInteraction000518651
      WBInteraction000536249
      WBInteraction000536261
      WBInteraction000536286
      WBInteraction000556194
      WBInteraction000558437
      WBInteraction000559657
      WBInteraction000561935
      WBInteraction000566133
      WBInteraction000568103
      WBInteraction000572461
  Map_info: Map: IV Position: 12.5086 Error: 0.002306
    Positive: Positive_clone: Y57G11C Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005928
    WBPaper00026715
    WBPaper00031194
    WBPaper00033840
    WBPaper00037471
    WBPaper00038491
    WBPaper00041233
    WBPaper00048636
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene