WormBase Tree Display for Gene: WBGene00006363

WBGene00006363 Evidence: Paper_evidence: WBPaper00005543
  SMap: S_parent: Sequence: F35D2
  Identity: Version: 1
    Name: CGC_name: syd-1 Person_evidence: WBPerson105
            WBPerson293
      Sequence_name: F35D2.5
      Molecular_name: F35D2.5a
        F35D2.5a.1
        CE33391
        F35D2.5c
        CE33392
        F35D2.5c.1
        F35D2.5c.2
      Other_name: CELE_F35D2.5 Accession_evidence: NDB BX284602
      Public_name: syd-1
    DB_info: Database: AceView gene 2H876
        WormQTL gene WBGene00006363
        WormFlux gene WBGene00006363
        NDB locus_tag CELE_F35D2.5
        Panther gene CAEEL|WormBase=WBGene00006363|UniProtKB=Q86NH1
          family PTHR46150
        NCBI gene 174230
        RefSeq protein NM_001026975.4
            NM_001383891.2
        SwissProt UniProtAcc Q86NH1
        TREEFAM TREEFAM_ID TF323458
        UniProt_GCRP UniProtAcc Q86NH1
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: syd
    Allele (120)
    Strain: WBStrain00032087
      WBStrain00037967
      WBStrain00005369
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (39)
    Paralog: WBGene00015267 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: syd-1 encodes a protein that contains a Rho-GTPase-like activating domain as well as PDZ and C2 domains; during neuronal development, SYD-1 is required cell autonomously to positively regulate synaptogenesis; in regulating synapse development, SYD-1 functions as a positive regulator of SYD-2/liprin through direct interaction with ELKS-1, a pre-synaptic protein also required for synapse development; in turn, SYD-1 activity is regulated by RSY-1, a negative regulator of synaptogenesis, with which it also interacts physically; SYD-1 is expressed in neurons and localizes to presynaptic regions. Paper_evidence: WBPaper00005543
            WBPaper00028808
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Mar 2010 00:00:00
      Automated_description: Enables GTPase activator activity; Roundabout binding activity; and small GTPase binding activity. Involved in cell projection organization; cellular localization; and locomotion. Located in presynaptic membrane. Expressed in nerve ring and neurons. Is an ortholog of human SYDE2 (synapse defective Rho GTPase homolog 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F35D2.5a
      F35D2.5c
    Corresponding_CDS_history: F35D2.5:wp84
      F35D2.5:wp92
      F35D2.5b:wp93
      F35D2.5b:wp274
    Corresponding_transcript (3)
    Other_sequence (15)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00082910 Inferred_automatically: RNAi_primary
      WBRNAi00046330 Inferred_automatically: RNAi_primary
      WBRNAi00031774 Inferred_automatically: RNAi_primary
      WBRNAi00014326 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000711
      WBCnstr00000728
      WBCnstr00010752
      WBCnstr00034391
    Construct_product: WBCnstr00000728
      WBCnstr00007017
      WBCnstr00010752
      WBCnstr00010753
      WBCnstr00012368
      WBCnstr00012375
      WBCnstr00018295
      WBCnstr00021865
      WBCnstr00034391
      WBCnstr00038079
    Antibody: WBAntibody00000569
    Microarray_results (33)
    Expression_cluster: WBPaper00024970:GABAergic_neuron_specific
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:A-class-motor-neurons_CoreEnriched
      WBPaper00037950:A-class-motor-neurons_embryo_enriched
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050231:male_enriched
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055648:nerve-ring_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058678:DAF-12_upregulated_PVD
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADE
      WBPaper00061340:AIA
      WBPaper00061340:AIY
      WBPaper00061340:AIZ
      WBPaper00061340:ALN
      WBPaper00061340:AUA
      WBPaper00061340:AVG
      WBPaper00061340:AVJ
      WBPaper00061340:CEP
      WBPaper00061340:DA
      WBPaper00061340:DA_DB
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:DVA
      WBPaper00061340:FLP
      WBPaper00061340:I5
      WBPaper00061340:IL1
      WBPaper00061340:MC
      WBPaper00061340:OLL
      WBPaper00061340:OLQ
      WBPaper00061340:RIA
      WBPaper00061340:RIC
      WBPaper00061340:RIM
      WBPaper00061340:RIS
      WBPaper00061340:RME
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:ckr-1-T09B9.3
      WBPaper00061527:syd-1_2945-unc-41_2170
      WBPaper00061651:RIA_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:17_0
      WBPaper00065841:19_0
      WBPaper00065841:36_2
      WBPaper00065841:58_1
      WBPaper00065841:83_0
      WBPaper00065841:87_0
      WBPaper00065841:100_0
      WBPaper00065841:145_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_2
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042548:miRISC_enriched
      WBPaper00045374:Benzene_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:xpa-1_UV_downregulated
    Interaction: WBInteraction000052939
      WBInteraction000502072
      WBInteraction000502714
      WBInteraction000502715
      WBInteraction000502837
      WBInteraction000504813
      WBInteraction000517453
      WBInteraction000523867
      WBInteraction000523870
      WBInteraction000540845
      WBInteraction000540846
      WBInteraction000541722
      WBInteraction000542027
      WBInteraction000542028
      WBInteraction000542029
      WBInteraction000543137
      WBInteraction000544277
      WBInteraction000544584
      WBInteraction000544684
      WBInteraction000546455
      WBInteraction000547569
      WBInteraction000547986
      WBInteraction000547987
      WBInteraction000547988
      WBInteraction000547989
      WBInteraction000555533
      WBInteraction000555534
      WBInteraction000555535
      WBInteraction000556331
      WBInteraction000557944
      WBInteraction000557945
      WBInteraction000557946
      WBInteraction000557947
      WBInteraction000557948
      WBInteraction000557949
      WBInteraction000557950
      WBInteraction000557955
      WBInteraction000557956
      WBInteraction000557957
      WBInteraction000557958
      WBInteraction000557959
      WBInteraction000557960
      WBInteraction000557961
      WBInteraction000557962
      WBInteraction000557963
      WBInteraction000557964
      WBInteraction000570718
      WBInteraction000570721
      WBInteraction000578492
      WBInteraction000583659
      WBInteraction000584024
  Map_info: Map: II Position: 0.504817 Error: 4.2e-05
    Positive: Positive_clone: F35D2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4188
        4715
        4733
        5534
    Pseudo_map_position
  Reference (52)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene