WormBase Tree Display for Gene: WBGene00001371

WBGene00001371 Evidence: Person_evidence: WBPerson260
  SMap: S_parent: Sequence: F26H11
  Identity: Version: 1
    Name: CGC_name: exl-1 Person_evidence: WBPerson260
      Sequence_name: F26H11.5
      Molecular_name: F26H11.5
        F26H11.5.1
        CE24922
      Other_name: CELE_F26H11.5 Accession_evidence: NDB BX284602
      Public_name: exl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: exl
    Allele (33)
    Strain: WBStrain00031671
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (47)
    Paralog: WBGene00001365 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001790 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001791 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001792 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008920 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015337 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016204 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019636 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021817 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00043097 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: exl-1 encodes a putative chloride intracellular channel (CLIC) paralogous to EXC-4; transgenic EXL-1 can partially rescue the exc-4(rh133) mutant phenotype when its expression is driven with an exc-4 promoter; EXL-1 is localized to lysosomes in intestinal cells and coelomocytes, endoplasmic reticulum in coelomocytes, Golgi apparatus in muscle and the neurons PVD and CAN, plasma membrane in muscle arms, and to dense bodies linking muscle cytoskeleton to hypodermis through muscle cell membranes; EXL-1 has an N-terminal PTM domain required for its membrane targeting, and a C-terminal domain resembling omega-type glutathione-S-transferases; EXL-1 has no known function in vivo, and exl-1(ok857) mutants have no obvious phenotype. Paper_evidence: WBPaper00006263
            WBPaper00027655
          Curator_confirmed: WBPerson567
          Date_last_updated: 18 Jan 2008 00:00:00
      Automated_description: Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in apical plasma membrane; cytoplasm; and muscle cell projection membrane. Expressed in coelomocyte; intestine; muscle cell; and neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome. Is an ortholog of human CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00040625
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 Apr 2019 00:00:00
    Potential_model: DOID:0060828 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2063)
  Models_disease_asserted: WBDOannot00000653
  Molecular_info: Corresponding_CDS: F26H11.5
    Corresponding_transcript: F26H11.5.1
    Other_sequence: Tcol_isotig00207
      CBC02920_1
      FD517449.1
      CSC01417_1
    Associated_feature: WBsf666366
      WBsf666367
      WBsf666368
      WBsf990706
      WBsf1013839
      WBsf224272
  Experimental_info: RNAi_result: WBRNAi00031474 Inferred_automatically: RNAi_primary
      WBRNAi00013985 Inferred_automatically: RNAi_primary
      WBRNAi00045703 Inferred_automatically: RNAi_primary
      WBRNAi00090593 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2810
      Expr9874
      Expr1015562
      Expr1030826
      Expr1149614
      Expr2011395
      Expr2029631
    Drives_construct: WBCnstr00010963
      WBCnstr00012955
      WBCnstr00014373
      WBCnstr00015737
      WBCnstr00036986
    Construct_product: WBCnstr00010963
      WBCnstr00012955
      WBCnstr00014373
      WBCnstr00015737
      WBCnstr00036986
    Microarray_results (17)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:rising_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00046497:B.thuringiensis_upregulated_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:downregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:BWM_far_posterior
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:R119.3_3379-fars-2_2630
      WBPaper00061651:BDU_enriched
      WBPaper00061651:PVD_enriched
      WBPaper00062193:hsf-1(RNAi)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065841:70_0
      WBPaper00065841:70_1
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066085:sin-3(tm1276)_downregulated
      cgc4386_cluster_2_3
      cgc4489_group_11
      WBPaper00025032:cluster_1
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00036123:Cadmium_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00037113:Diazinon_16C_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction: WBInteraction000114303
      WBInteraction000122653
      WBInteraction000152397
      WBInteraction000152398
      WBInteraction000159763
      WBInteraction000159764
      WBInteraction000159765
      WBInteraction000159766
      WBInteraction000169488
      WBInteraction000193237
      WBInteraction000226226
      WBInteraction000348992
      WBInteraction000361626
      WBInteraction000427059
      WBInteraction000429055
      WBInteraction000439557
      WBInteraction000440175
      WBInteraction000461878
      WBInteraction000547910
  Map_info: Map: II Position: 22.9676 Error: 0.006188
    Positive: Positive_clone: F26H11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4590
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene