WormBase Tree Display for Gene: WBGene00016204
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| WBGene00016204 | SMap | S_parent | Sequence | C29E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gsto-1 | Paper_evidence | WBPaper00031042 | |||||
| Sequence_name | C29E4.7 | ||||||||
| Molecular_name | C29E4.7 | ||||||||
| C29E4.7.1 | |||||||||
| CE00089 | |||||||||
| Other_name | CELE_C29E4.7 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | gsto-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Oct 2007 09:47:18 | WBPerson2970 | Name_change | CGC_name | gsto-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gsto | ||||||||
| Allele (25) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001792 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015337 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00043097 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019636 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001365 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001371 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001790 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001791 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008920 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021817 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site. | Paper_evidence | WBPaper00031042 | |||||
| WBPaper00031083 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 16 Oct 2007 00:00:00 | ||||||||
| Automated_description | Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in cellular response to extracellular stimulus; obsolete oxidation-reduction process; and response to superoxide. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Is an ortholog of human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | ||||
| DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23064) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | ||||||
| Molecular_info | Corresponding_CDS | C29E4.7 | |||||||
| Corresponding_transcript | C29E4.7.1 | ||||||||
| Other_sequence | CBC14472_1 | ||||||||
| AF203814.2 | |||||||||
| CJC05775_1 | |||||||||
| Associated_feature | WBsf034318 | ||||||||
| WBsf667116 | |||||||||
| WBsf227052 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr4883 | ||||||||
| Expr4884 | |||||||||
| Expr1021261 | |||||||||
| Expr1036937 | |||||||||
| Expr1145482 | |||||||||
| Expr2012336 | |||||||||
| Expr2030573 | |||||||||
| Drives_construct | WBCnstr00012309 | ||||||||
| WBCnstr00028246 | |||||||||
| Construct_product | WBCnstr00012309 | ||||||||
| WBCnstr00028246 | |||||||||
| Antibody | WBAntibody00001308 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (227) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | III | Position | -0.473487 | Error | 0.00203 | |||
| Positive | Positive_clone | C29E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024841 | ||||||||
| WBPaper00031042 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042271 | |||||||||
| WBPaper00045842 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
