| WBGene00000092 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F32A6 |
| Identity | Version | 1 |
| | Name | CGC_name | ags-3 | Person_evidence | WBPerson8 |
| | | Sequence_name | F32A6.4 |
| | | Molecular_name (22) |
| | | Other_name | ags-3.1 |
| | | | CELE_F32A6.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | ags-3 |
| | DB_info | Database | AceView | gene | XF910 |
| | | | WormQTL | gene | WBGene00000092 |
| | | | WormFlux | gene | WBGene00000092 |
| | | | NDB | locus_tag | CELE_F32A6.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000092|UniProtKB=Q19955 |
| | | | | family | PTHR45954 |
| | | | NCBI | gene | 180801 |
| | | | RefSeq | protein | NM_001322619.4 |
| | | | | | NR_136376.1 |
| | | | | | NM_001322621.4 |
| | | | | | NM_171684.6 |
| | | | | | NM_001322618.4 |
| | | | | | NR_136377.1 |
| | | | | | NM_001383577.1 |
| | | | TrEMBL | UniProtAcc | A0A131MD77 |
| | | | | | A0A131MBA1 |
| | | | | | A0A131MBC1 |
| | | | | | A0A131MBW5 |
| | | | | | Q19955 |
| | | | UniProt_GCRP | UniProtAcc | Q19955 |
| | | | RNAcentral | URSid | URS00009CD78A |
| | | | | | URS00009E5227 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ags |
| | Allele (220) |
| | Strain | WBStrain00001170 |
| | | WBStrain00001463 |
| | | WBStrain00031847 |
| | | WBStrain00036344 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog (40) |
| | Paralog | WBGene00004507 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00021247 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | ags-3 encodes a protein containing N-terminal TRP domains and C-terminal GPR domains that is a member of the Activator of G Protein Signaling 3 (AGS3) family of proteins that includes mammalian AGS3 and LPN and Drosophila RAPSYNOID; in C. elegans, AGS-3 is involved in polarity and spindle orientation during early embryogenesis; in addition, AGS-3, along with the RIC-8 guanine nucleotide exchange factor, has been shown to activate GOA-1/Galpha0 in the ASH chemosensory neurons to modulate behavior after food deprivation; full length AGS-3 binds inactive GOA-1 (GOA-1-GDP) in pull down assays, while AGS-3 fragments containing the GPR domains (also known as GoLoco domains) bind activated GOA-1 (GOA-1-GTP) in pull down assays and GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots; in adults, an ags-3 reporter fusion is seen in nearly all neurons, including the ASH chemosensory neurons, and in body wall muscle, egg-laying muscles, and pharyngeal muscles; AGS-3 subcellular localization is regulated by food deprivation: AGS-3 moves from a Triton X-100 insoluble pellet fraction to a Triton X-100 soluble pellet fraction after several hours of food deprivation. | Paper_evidence | WBPaper00004782 |
| | | | | | WBPaper00005945 |
| | | | | | WBPaper00006194 |
| | | | | | WBPaper00040078 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 19 Aug 2011 00:00:00 |
| | | Automated_description | Enables G-protein alpha-subunit binding activity. Involved in regulation of feeding behavior. Located in membrane. Expressed in several structures, including hermaphrodite gonad; intestine; muscle cell; neurons; and tail. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Is an ortholog of human GPSM1 (G protein signaling modulator 1) and GPSM2 (G protein signaling modulator 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29501) |
| Molecular_info | Corresponding_CDS | F32A6.4a |
| | | F32A6.4d |
| | | F32A6.4e |
| | | F32A6.4f |
| | | F32A6.4g |
| | Corresponding_CDS_history | F32A6.4b:wp252 |
| | | F32A6.4c:wp252 |
| | Corresponding_transcript (12) |
| | Other_sequence (25) |
| | Associated_feature (14) |
| Experimental_info | RNAi_result | WBRNAi00046084 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061394 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00031648 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063377 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063365 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00097948 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00088424 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00014199 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00002062 |
| | | WBCnstr00004206 |
| | | WBCnstr00010933 |
| | | WBCnstr00013914 |
| | Construct_product | WBCnstr00010933 |
| | Antibody | WBAntibody00002292 |
| | Microarray_results (33) |
| | Expression_cluster | WBPaper00029359_1168 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1225 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1494 |
| | | WBPaper00029359_1546 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_downregulated_cDNA_24h |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_CoreEnriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056167:ifo-1(kc2)_upregulated |
| | | WBPaper00056218:daf-16(mu86)_upregulated_Day7 |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_acr-2(n2420gf)_regulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:acy-2-F35C5.11 |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061651:ADF_enriched |
| | | WBPaper00061651:AUA_enriched |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:AWA_enriched |
| | | WBPaper00061651:AWC_ON_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:PVP_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:RIH_enriched |
| | | WBPaper00061651:RIP_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065841:50_0 |
| | | WBPaper00065841:58_0 |
| | | WBPaper00065841:90_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:116_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | cgc4386_cluster_5_1 |
| | | cgc4489_group_6 |
| | | WBPaper00025032:cluster_71 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction | WBInteraction000029545 |
| | | WBInteraction000166977 |
| | | WBInteraction000167155 |
| | | WBInteraction000184158 |
| | | WBInteraction000188602 |
| | | WBInteraction000192150 |
| | | WBInteraction000193527 |
| | | WBInteraction000202710 |
| | | WBInteraction000205394 |
| | | WBInteraction000206008 |
| | | WBInteraction000206180 |
| | | WBInteraction000208539 |
| | | WBInteraction000211281 |
| | | WBInteraction000211634 |
| | | WBInteraction000216305 |
| | | WBInteraction000216357 |
| | | WBInteraction000232510 |
| | | WBInteraction000239109 |
| | | WBInteraction000240257 |
| | | WBInteraction000242788 |
| | | WBInteraction000255062 |
| | | WBInteraction000255512 |
| | | WBInteraction000260243 |
| | | WBInteraction000265252 |
| | | WBInteraction000267263 |
| | | WBInteraction000271918 |
| | | WBInteraction000283585 |
| | | WBInteraction000301679 |
| | | WBInteraction000313384 |
| | | WBInteraction000319227 |
| | | WBInteraction000327528 |
| | | WBInteraction000366267 |
| | | WBInteraction000382681 |
| | | WBInteraction000386040 |
| | | WBInteraction000388077 |
| | | WBInteraction000397163 |
| | | WBInteraction000411698 |
| | | WBInteraction000449174 |
| | | WBInteraction000511745 |
| | | WBInteraction000511751 |
| | | WBInteraction000511752 |
| | | WBInteraction000511755 |
| | | WBInteraction000511756 |
| | | WBInteraction000511757 |
| | | WBInteraction000511771 |
| | | WBInteraction000522475 |
| | | WBInteraction000524564 |
| | | WBInteraction000542819 |
| | | WBInteraction000542831 |
| | | WBInteraction000543632 |
| | | WBInteraction000543633 |
| | | WBInteraction000543634 |
| | | WBInteraction000543635 |
| | | WBInteraction000543636 |
| | | WBInteraction000544207 |
| | | WBInteraction000544336 |
| | | WBInteraction000556599 |
| | | WBInteraction000556600 |
| | | WBInteraction000556601 |
| | | WBInteraction000556602 |
| | | WBInteraction000556655 |
| | | WBInteraction000502915 |
| Map_info | Map | X | Position | -5.74685 | Error | 0.011682 |
| | Positive | Positive_clone | F32A6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4885 |
| | Pseudo_map_position |
| Reference (12) |
| Remark | Sequence connection from [Ahringer JA] |
| | Sequence connection updated by Darin Blasiar, Feb 2002 |
| | Gene renamed from ags-3.1 to ags-3 following advice from [Hodgkin J], [020808 krb] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
