WBGene00002991 | SMap | S_parent | Sequence | F17E5 |
| Identity | Version | 1 |
| | Name | CGC_name | lin-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | F17E5.1 |
| | | Molecular_name | F17E5.1a |
| | | | F17E5.1a.1 |
| | | | CE27131 |
| | | | F17E5.1b |
| | | | CE27132 |
| | | | F17E5.1b.1 |
| | | Other_name | CELE_F17E5.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lin-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00143908 |
| | Allele (248) |
| | Possibly_affected_by | WBVar02157232 |
| | Legacy_information (3) |
| | Strain (14) |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (43) |
| | Paralog | WBGene00006467 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00016841 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00021914 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | lin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane. | Paper_evidence | WBPaper00000496 |
| | | | | | WBPaper00003215 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 31 Jan 2006 00:00:00 |
| | | Automated_description | Enables insulin-like growth factor receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to membrane. Located in cell junction. Expressed in several structures, including CAN; HSN; isthmus; somatic nervous system; and vulval precursor cell. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Is an ortholog of human CASK (calcium/calmodulin dependent serine protein kinase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info (2) |
| Models_disease_asserted | WBDOannot00000474 |
| Molecular_info | Corresponding_CDS | F17E5.1a |
| | | F17E5.1b |
| | Corresponding_CDS_history | F17E5.1a:wp47 |
| | | F17E5.1b:wp47 |
| | Corresponding_transcript | F17E5.1a.1 |
| | | F17E5.1b.1 |
| | Other_sequence (49) |
| | Associated_feature (16) |
| Experimental_info | RNAi_result | WBRNAi00013468 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00030265 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00044888 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000540 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076312 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00022290 |
| | | WBCnstr00036300 |
| | Construct_product | WBCnstr00012382 |
| | | WBCnstr00021427 |
| | | WBCnstr00036300 |
| | | WBCnstr00038376 |
| | | WBCnstr00038378 |
| | | WBCnstr00041675 |
| | Antibody | WBAntibody00000973 |
| | | WBAntibody00001507 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033070:Elbe_downregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049290:rsks-1(sv31)_upregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:SAA_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_16 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | [cgc6390]:Cluster_B |
| | | [cgc6390]:herm_soma-enriched |
| | Interaction (292) |
| Map_info | Map | X | Position | 7.04058 | Error | 0.007077 |
| | Well_ordered |
| | Positive | Inside_rearr | yDp11 |
| | | Positive_clone | C43C10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | F17E5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 168 |
| | | | 280 |
| | | | 281 |
| | | Multi_point (25) |
| | | Pos_neg_data | 320 |
| | | | 686 |
| | | | 687 |
| | | | 871 |
| | | | 8424 |
| | | | 8431 |
| | | | 8443 |
| | | | 8451 |
| | | | 8457 |
| | Landmark_gene |
| Reference (172) |
| Method | Gene |