WBGene00001080 | Evidence | Paper_evidence | WBPaper00006355 |
| SMap | S_parent | Sequence | Y59A8B |
| Identity | Version | 1 |
| | Name | CGC_name | dpy-21 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y59A8B.1 |
| | | Molecular_name | Y59A8B.1a |
| | | | Y59A8B.1a.1 |
| | | | CE26205 |
| | | | Y59A8B.1b |
| | | Other_name | Y59A8B.c | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CELE_Y59A8B.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | dpy-21 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dpy |
| | Reference_allele | WBVar00143205 |
| | Allele (428) |
| | Legacy_information | e428 : weak dumpy (XX) non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae). ME3. NA3 (e459 (resembles e428) ct16 (very weak dumpy)). |
| | | See also e428, e459, e1483 |
| | | [C.elegansII] e428 : weak dumpy (XX); non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae).Some X chromosome transcript levels elevated,in both XX and XO. ME3. OA2: e459 (resembles e428), ct16 (very weak phenotype). [Hodgkin 1983b; Meyer and Casson 1986; TY] |
| | Strain (20) |
| | RNASeq_FPKM (74) |
| | GO_annotation (12) |
| | Contained_in_operon | CEOP5552 |
| | Ortholog (36) |
| | Structured_description | Concise_description | dpy-21 encodes a novel, conserved protein with a proline-rich N terminus; dpy-21 affects RNA levels of X-linked dosage-compensated genes, body length in hermaphrodites, and fertility and male tail development in males; DPY-21 interacts in vivo with DPY-27 and SDC-3, members of the dosage compensation complex, and like members of the dosage compensation complex, is diffusely localized in nuclei of XX embryos containing <40 cells, but then specifically localizes to X chromosomes of XX embryos with >40 cells, remaining on the X throughout development; in XO embryos, DPY-21 is dispersed throughout the nucleus in multiple foci that are not coincident with the X chromosome; in hermaphrodites, localization of DPY-21 to the X chromosome requires activity of SDC-2, SDC-3, DPY-26, DPY-27, and DPY-28; DPY-21 is not, however, required reciprocally for the stability or localization of these other dosage compensation proteins; in addition, unlike SDC-3 and other members of the dosage compensation complex, DPY-21 is not recruited to the autosomal her-1 regulatory region, suggesting that DPY-21 is not part of the gene-specific complex that represses her-1 expression in hermaphrodites. | Paper_evidence | WBPaper00000665 |
| | | | | | WBPaper00000941 |
| | | | | | WBPaper00001003 |
| | | | | | WBPaper00006355 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 17 Jul 2006 00:00:00 |
| | | Automated_description | Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y59A8B.1a |
| | Corresponding_CDS_history | Y59A8B.1:wp139 |
| | Corresponding_transcript | Y59A8B.1b |
| | | Y59A8B.1a.1 |
| | Other_sequence (17) |
| | Associated_feature | WBsf653522 |
| | | WBsf982072 |
| | | WBsf1002778 |
| | | WBsf1002779 |
| | | WBsf014601 |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern | Expr2896 |
| | | Expr13514 |
| | | Expr1027959 |
| | | Expr1030687 |
| | | Expr1161165 |
| | | Expr2011064 |
| | | Expr2029301 |
| | Regulate_expr_cluster | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | Antibody | WBAntibody00000707 |
| | | WBAntibody00000708 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00032031:DConiospora_downregulated_cDNA_12h |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053606:N2_vs_elt-7(tm840)_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00058711:paraquat_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059194:KLF-1_interacting |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:nrde-3-tra-4_10484 |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064789:Day9_vs_Day1_downregulated_neuron |
| | | WBPaper00065005:sams-3(RNAi)_upregulated |
| | | WBPaper00065005:sams-4(RNAi)_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4489_group_14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027111:rrf-1(pk1417)_upregulated |
| | | WBPaper00027111:rrf-2(ok210)_upregulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | Interaction (71) |
| | WBProcess | WBbiopr:00000056 |
| Map_info | Map | V | Position | 13.3323 | Error | 0.006986 |
| | Well_ordered |
| | Positive | Inside_rearr | ozDf1 |
| | | Positive_clone | Y59A8B | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | ozDf2 |
| | Mapping_data (3) |
| | Landmark_gene |
| Reference | WBPaper00000178 |
| | WBPaper00000179 |
| | WBPaper00000498 |
| | WBPaper00000608 |
| | WBPaper00000665 |
| | WBPaper00000666 |
| | WBPaper00000724 |
| | WBPaper00000916 |
| | WBPaper00000941 |
| | WBPaper00000987 |
| | WBPaper00001003 |
| | WBPaper00001011 |
| | WBPaper00001013 |
| | WBPaper00001028 |
| | WBPaper00001042 |
| | WBPaper00001077 |
| | WBPaper00001115 |
| | WBPaper00001116 |
| | WBPaper00001206 |
| | WBPaper00001279 |
| | WBPaper00001341 |
| | WBPaper00001563 |
| | WBPaper00001639 |
| | WBPaper00001659 |
| | WBPaper00001772 |
| | WBPaper00001842 |
| | WBPaper00001898 |
| | WBPaper00001955 |
| | WBPaper00001991 |
| | WBPaper00002074 |
| | WBPaper00002131 |
| | WBPaper00002278 |
| | WBPaper00002302 |
| | WBPaper00002303 |
| | WBPaper00002305 |
| | WBPaper00002347 |
| | WBPaper00002605 |
| | WBPaper00002606 |
| | WBPaper00002631 |
| | WBPaper00002743 |
| | WBPaper00002765 |
| | WBPaper00003597 |
| | WBPaper00004130 |
| | WBPaper00004158 |
| | WBPaper00004467 |
| | WBPaper00005237 |
| | WBPaper00005272 |
| | WBPaper00006355 |
| | WBPaper00013718 |
| | WBPaper00013778 |
| | WBPaper00013841 |
| | WBPaper00013844 |
| | WBPaper00013900 |
| | WBPaper00013953 |
| | WBPaper00014003 |
| | WBPaper00014204 |
| | WBPaper00014206 |
| | WBPaper00014251 |
| | WBPaper00014321 |
| | WBPaper00014783 |
| | WBPaper00014925 |
| | WBPaper00014926 |
| | WBPaper00015104 |
| | WBPaper00015147 |
| | WBPaper00015167 |
| | WBPaper00015918 |
| | WBPaper00015943 |
| | WBPaper00016131 |
| | WBPaper00016147 |
| | WBPaper00016149 |
| | WBPaper00016157 |
| | WBPaper00016180 |
| | WBPaper00016237 |
| | WBPaper00016243 |
| | WBPaper00016288 |
| | WBPaper00016312 |
| | WBPaper00016313 |
| | WBPaper00016339 |
| | WBPaper00016417 |
| | WBPaper00016418 |
| | WBPaper00016419 |
| | WBPaper00016420 |
| | WBPaper00016421 |
| | WBPaper00016483 |
| | WBPaper00016500 |
| | WBPaper00016502 |
| | WBPaper00016503 |
| | WBPaper00016556 |
| | WBPaper00016816 |
| | WBPaper00017044 |
| | WBPaper00017255 |
| | WBPaper00017475 |
| | WBPaper00018096 |
| | WBPaper00018403 |
| | WBPaper00021710 |
| | WBPaper00022074 |
| | WBPaper00022895 |
| | WBPaper00027240 |
| | WBPaper00027275 |
| | WBPaper00027297 |
| | WBPaper00029020 |
| | WBPaper00030871 |
| | WBPaper00030930 |
| | WBPaper00031224 |
| | WBPaper00035408 |
| | WBPaper00038491 |
| | WBPaper00038880 |
| | WBPaper00040306 |
| | WBPaper00042462 |
| | WBPaper00042679 |
| | WBPaper00043168 |
| | WBPaper00043971 |
| | WBPaper00044242 |
| | WBPaper00046016 |
| | WBPaper00048953 |
| | WBPaper00050801 |
| | WBPaper00053002 |
| | WBPaper00053662 |
| | WBPaper00053748 |
| | WBPaper00055090 |
| | WBPaper00062335 |
| | WBPaper00062532 |
| | WBPaper00064064 |
| | WBPaper00065308 |
| Method | Gene |