No mutants known. Encodes predicted 235aa protein, residues 100-235 have 37% identity to mammalian caveolin-1, 32% identity to mammalian caveolin-2, similar properties to mammalian caveolins when expressed in COS cells. 1.4 kb transcript detected, more abundant in eggs. Predicted gene T13F2.8
cav-1 encodes one of two C. elegans caveolin orthologs; cav-1 is required for viability and Ras/MAP-kinase-dependent progression through the meiotic cell cycle; CAV-1 is expressed in the adult germ line and during embryonic development; CAV-1::GFP localizes to cortical granules that function to secrete chondroitin and mucin-like proteoglycans to the extracellular space following fertilization.
Predicted to enable molecular adaptor activity. Involved in Ras protein signal transduction; meiotic cell cycle; and regulation of egg-laying behavior. Located in cytoplasm and cytoplasmic side of plasma membrane. Expressed in several structures, including germ cell; gonad arm; nervous system; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including distal muscular dystrophy Tateyama type; glaucoma (multiple); lipodystrophy (multiple); and systemic scleroderma (multiple). Is an ortholog of human CAV1 (caveolin 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.