WormBase Tree Display for Gene: WBGene00001149

WBGene00001149 SMap: S_parent: Sequence: K02A4
  Identity: Version: 2
    Name: CGC_name: bcat-1
      Sequence_name: K02A4.1
      Molecular_name: K02A4.1
        K02A4.1.1
        CE03457
      Other_name: ECA39 Accession_evidence: EMBL U21550
        eca-39
        CELE_K02A4.1 Accession_evidence: NDB BX284606
      Public_name: bcat-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 07 Jul 2004 10:08:30 WBPerson1971 Name_change: CGC_name: bcat-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bcat
    Allele (46)
    Strain: WBStrain00001179
      WBStrain00001764
      WBStrain00047484
    Component_of_genotype: WBGenotype00000032
      WBGenotype00000033
      WBGenotype00000034
    RNASeq_FPKM (74)
    GO_annotation: 00048321
      00048322
      00048323
      00048324
      00048325
      00048326
      00048327
      00048328
      00048329
      00048330
      00048331
      00048332
      00048333
      00048334
      00048335
      00048336
      00048337
      00048338
      00048339
      00048340
      00048341
      00048342
      00048343
      00048344
      00048345
      00048346
      00108322
      00108323
      00108324
    Ortholog (45)
    Paralog: WBGene00012855 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: bcat-1 encodes a branched-chain amino acid aminotransferase that, by homology, is predicted to catalyze the first reaction in the catabolism of essential branched-chain amino acids such as leucine, isoleucine, and valine; in C. elegans, large-scale RNA-mediated interference (RNAi) screens indicate that bcat-1 activity is required for embryonic and larval development. Paper_evidence: WBPaper00004424
            WBPaper00004651
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Apr 2007 00:00:00
      Automated_description: Predicted to enable branched-chain-amino-acid transaminase activity. Involved in branched-chain amino acid catabolic process; embryo development; and nematode larval development. Acts upstream of or within determination of adult lifespan. Located in mitochondrion. Is an ortholog of human BCAT2 (branched chain amino acid transaminase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K02A4.1
    Corresponding_transcript: K02A4.1.1
    Other_sequence (65)
    Associated_feature: WBsf717381
      WBsf717382
      WBsf982257
      WBsf1007453
      WBsf1007454
      WBsf1007455
      WBsf1024141
      WBsf236520
  Experimental_info: RNAi_result: WBRNAi00000799 Inferred_automatically: RNAi_primary
      WBRNAi00027821 Inferred_automatically: RNAi_primary
      WBRNAi00113698 Inferred_automatically: RNAi_primary
      WBRNAi00016424 Inferred_automatically: RNAi_primary
      WBRNAi00090701 Inferred_automatically: RNAi_primary
      WBRNAi00113697 Inferred_automatically: RNAi_primary
      WBRNAi00049654 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1431
      Chronogram1998
      Expr6303
      Expr9526
      Expr12614
      Expr1016785
      Expr1030730
      Expr1153380
      Expr2009579
      Expr2027816
    Drives_construct: WBCnstr00002071
      WBCnstr00004210
      WBCnstr00022449
      WBCnstr00037065
      WBCnstr00038736
    Construct_product: WBCnstr00014091
      WBCnstr00022449
      WBCnstr00037065
      WBCnstr00038736
    Regulate_expr_cluster: WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
    Microarray_results (24)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00029359_1145
      WBPaper00029359_1197
      WBPaper00029359_1208
      WBPaper00029359_1225
      WBPaper00029359_1242
      WBPaper00029359_1291
      WBPaper00029359_1367
      WBPaper00029359_1483
      WBPaper00029359_1494
      WBPaper00029359_1546
      WBPaper00029359_1561
      WBPaper00029359_1692
      WBPaper00032425:down_in_zfp-1
      WBPaper00032528:L3_enriched
      WBPaper00032976:dosage_compensated_genes
      WBPaper00035073:mitochondria_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044128:daf-2(e1370)_downregulated
      WBPaper00044128:DietaryRestriction_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00046121:endoderm_unique
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00046741:Garlic-Extract_upregulated_mRNA
      WBPaper00046795:starvation_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049083:post-dauer-development_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00052987:UV_downregulated_xpc-1;csb-1
      WBPaper00053254:hsp-90(RNAi)_downregulated_protein
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060006:nfyb-1(cu13)_upregulated_transcript
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061405:S.aureus_upregulated_starvation
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061651:Gonadal_sheath_cell_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062156:jmjd-5(zr1234)_upregulated_germline
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064841:tent-5(tm3504)_upregulated_protein
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4386_cluster_1_2
      cgc4489_group_3
      WBPaper00025032:cluster_23
      WBPaper00025032:cluster_54
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
      WBPaper00040426:CYE-1_CDK-2AF_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040876:mir-35_upregulated
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041211:RPW-24_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00053688:E.faecium_downregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc6390]:Cluster_C
      [cgc6390]:herm_soma-enriched
    Interaction (153)
  Map_info: Map: X Position: 8.78096
    Positive: Positive_clone: K02A4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene