WormBase Tree Display for Gene: WBGene00000536
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| WBGene00000536 | Evidence | Paper_evidence | WBPaper00013270 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZC395 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | clk-1 | Person_evidence | WBPerson247 | |||||
| Sequence_name | ZC395.2 | ||||||||
| Molecular_name | ZC395.2 | ||||||||
| ZC395.2.1 | |||||||||
| CE01438 | |||||||||
| Other_name | coq-7 | CGC_data_submission | |||||||
| coq-1 | |||||||||
| CELE_ZC395.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | clk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clk | ||||||||
| Allele (17) | |||||||||
| Legacy_information | [Hekimi S] Phenotype is slow growth. Strong maternal rescue of M+ Z- worms. Zygotically rescued. clk-1(qm30) worms are viable at 20C but become sterile at 25C. | ||||||||
| [Hekimi S] e2519mat growth and behavior slowed by up to 2-fold. Profound zygotic and maternal rescue. Slow postembryonic development, slow cell cycle, long life span. Swimming, pumping, egg-laying, defecation all slow and irregular. OA4- qm30 (worms are viable at 20C but become sterile at 25C) | |||||||||
| [C.elegansII] e2519mat : growth and behavior slowed by up to 2-fold.Profound zygotic and maternal rescue.Slow postembryonic development, slow cell cycle,long life span. Swimming, pumping, egg-laying, defecation all slow and irregular. OA4: qm30 (worms are viable at 20C but become sterile at 25C) qm11, qm47, qm51. Cloned: cosmid rescue (W03B11)[Wong et al. 1995] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (67) | |||||||||
| Contained_in_operon | CEOP3280 | ||||||||
| Ortholog (34) | |||||||||
| Structured_description | Concise_description | clk-1 encodes the C. elegans ortholog of COQ7/CAT5, a highly conserved demethoxyubiquinone (DMQ) hydroxylase that is necessary for the biosynthesis of ubiquinone (coenzyme Q, Q9) from 5-demethoxyubiquinone (DMQ9); in C. elegans, CLK-1 activity is required for normal physiological rates of growth, development, behavior, and aging, as well as for normal brood sizes. | Paper_evidence (3) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables transcription cis-regulatory region binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of multicellular organismal process; and regulation of macromolecule metabolic process. Located in mitochondrion and nucleus. Expressed widely. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 8. Is an ortholog of human COQ7 (coenzyme Q7, hydroxylase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070245 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2244) | ||||
| EFO:MONDO:0015363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2244) | ||||||
| Molecular_info (4) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1276 | ||||||||
| Expr2672 | |||||||||
| Expr12355 | |||||||||
| Expr1027159 | |||||||||
| Expr1030321 | |||||||||
| Expr1162308 | |||||||||
| Expr2010238 | |||||||||
| Expr2028480 | |||||||||
| Drives_construct | WBCnstr00001906 | ||||||||
| WBCnstr00007715 | |||||||||
| WBCnstr00010186 | |||||||||
| WBCnstr00020537 | |||||||||
| WBCnstr00020538 | |||||||||
| Construct_product | WBCnstr00007715 | ||||||||
| WBCnstr00010186 | |||||||||
| WBCnstr00020537 | |||||||||
| WBCnstr00020538 | |||||||||
| WBCnstr00040348 | |||||||||
| WBCnstr00040349 | |||||||||
| Regulate_expr_cluster (16) | |||||||||
| Antibody | WBAntibody00000689 | ||||||||
| WBAntibody00000690 | |||||||||
| WBAntibody00001063 | |||||||||
| WBAntibody00001605 | |||||||||
| WBAntibody00002953 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (92) | |||||||||
| SAGE_tag | SAGE:atgatgaagctcctcat | Strand | Antisense | ||||||
| SAGE:gttctttgca | Strand | Sense | |||||||
| Most_three_prime | |||||||||
| SAGE:ctggagagct | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:atactggagt | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:atactggagtagaacac | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:gaagaaaagg | Strand | Antisense | |||||||
| SAGE:ctggagagcttggagcc | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:atgatgaagc | Strand | Antisense | |||||||
| SAGE:gttctttgcaaaatatc | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (190) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000106 | |||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | III | Position | -1.84679 | Error | 0.003094 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDp3 | |||||||
| Positive_clone | ZC395 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| ZC400 | Person_evidence | WBPerson168 | |||||||
| Mapping_data | 2_point | 7067 | |||||||
| Multi_point | 2741 | ||||||||
| 2744 | |||||||||
| 2755 | |||||||||
| 3304 | |||||||||
| 3618 | |||||||||
| 3621 | |||||||||
| 3624 | |||||||||
| 3625 | |||||||||
| Pos_neg_data | 8730 | ||||||||
| 8731 | |||||||||
| 8736 | |||||||||
| 9313 | |||||||||
| Reference (306) | |||||||||
| Remark | [Ewbank J] Cloned: cosmid rescue (W03B11)" is false;ZC395 gives cosmid rescue | ||||||||
| Method | Gene |
