WormBase Tree Display for Gene: WBGene00006351

WBGene00006351 SMap: S_parent: Sequence: K03A1
  Identity: Version: 1
    Name: CGC_name: sur-5 Person_evidence: WBPerson237
      Sequence_name: K03A1.5
      Molecular_name: K03A1.5
        K03A1.5.1
        CE04713
      Other_name: CELE_K03A1.5 Accession_evidence: NDB BX284606
      Public_name: sur-5
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sur
    Allele (86)
    Legacy_information: [Gu T] sur-5 for suppressors of ras. Mutations in sur-5 suppress the vulvaless phenotype caused by let-60(sy94) dominant negative mutation. sur-5 mutations have no phenotype on their own.
    Complementation_data: [Gu T] ku74 failed to complement uDf1
    Strain: WBStrain00005188
      WBStrain00026507
      WBStrain00004760
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (44)
    Paralog: WBGene00007969 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009221 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012356 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013440 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016849 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018269 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018488 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018579 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sur-5 encodes a protein with high similarity to H. sapiens Acetoacetyl-coenzyme A synthetase; sur-5 negatively regulates let-60 during vulval induction, based on genetic analysis, and genetically synergises with lin-45 with respect to larval death, uncoordinated movement and egg-laying defects; sur-5 is strongly expressed in most cells of C. elegans, including the VPCs, and is localized primarily to the nucleus. Paper_evidence: WBPaper00003142
          Curator_confirmed: WBPerson48
          Date_last_updated: 14 Jul 2005 00:00:00
      Automated_description: Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; gonad; hypodermal cell; and somatic cell. Is an ortholog of human AACS (acetoacetyl-CoA synthetase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K03A1.5
    Corresponding_transcript: K03A1.5.1
    Other_sequence (38)
    Associated_feature: WBsf670020
      WBsf982195
      WBsf1005800
      WBsf1023223
      WBsf237562
      WBsf237563
      WBsf237564
      WBsf237565
      WBsf237566
  Experimental_info: RNAi_result: WBRNAi00087230 Inferred_automatically: RNAi_primary
      WBRNAi00049782 Inferred_automatically: RNAi_primary
      WBRNAi00000452 Inferred_automatically: RNAi_primary
      WBRNAi00016506 Inferred_automatically: RNAi_primary
      WBRNAi00033903 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1340
      Expr1416
      Expr12760
      Expr1027579
      Expr1032558
      Expr1153497
      Expr2017136
      Expr2035272
    Drives_construct: WBCnstr00000483
      WBCnstr00000493
      WBCnstr00000494
      WBCnstr00000806
      WBCnstr00001290
      WBCnstr00004893
      WBCnstr00005480
      WBCnstr00005555
      WBCnstr00006097
      WBCnstr00006116
      WBCnstr00006117
      WBCnstr00006122
      WBCnstr00006264
      WBCnstr00006265
      WBCnstr00006267
      WBCnstr00006268
      WBCnstr00006269
      WBCnstr00006279
      WBCnstr00006280
      WBCnstr00006308
      WBCnstr00006319
      WBCnstr00006332
      WBCnstr00006333
      WBCnstr00006420
      WBCnstr00006421
      WBCnstr00006829
      WBCnstr00006831
      WBCnstr00006929
      WBCnstr00007155
      WBCnstr00007211
      WBCnstr00007212
      WBCnstr00007213
      WBCnstr00007536
      WBCnstr00008144
      WBCnstr00008261
      WBCnstr00010002
      WBCnstr00014637
      WBCnstr00014639
      WBCnstr00014640
      WBCnstr00014642
      WBCnstr00015120
      WBCnstr00015657
      WBCnstr00015713
      WBCnstr00016061
      WBCnstr00016065
      WBCnstr00017587
      WBCnstr00018065
      WBCnstr00018066
      WBCnstr00018617
      WBCnstr00018618
      WBCnstr00018993
      WBCnstr00019164
      WBCnstr00019690
      WBCnstr00019753
      WBCnstr00019754
      WBCnstr00019755
      WBCnstr00019830
      WBCnstr00020359
      WBCnstr00020360
      WBCnstr00020379
      WBCnstr00020380
      WBCnstr00020395
      WBCnstr00020539
      WBCnstr00020874
      WBCnstr00020943
      WBCnstr00021052
      WBCnstr00021483
      WBCnstr00022633
      WBCnstr00022830
      WBCnstr00023091
      WBCnstr00034394
      WBCnstr00038244
      WBCnstr00039659
      WBCnstr00039660
      WBCnstr00040908
      WBCnstr00042118
      WBCnstr00042119
      WBCnstr00042837
    Construct_product: WBCnstr00006929
      WBCnstr00007155
      WBCnstr00016061
      WBCnstr00016065
      WBCnstr00023091
      WBCnstr00034394
      WBCnstr00042119
    Microarray_results (21)
    Expression_cluster (251)
    Interaction (89)
    WBProcess: WBbiopr:00000071
  Map_info: Map: X Position: -1.78093 Error: 0.00152
    Well_ordered
    Positive: Inside_rearr: uDf1
      Positive_clone: K03A1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3553
        4679
      Pos_neg_data: 9150
  Reference: WBPaper00003121
    WBPaper00003142
    WBPaper00003792
    WBPaper00003858
    WBPaper00003861
    WBPaper00004890
    WBPaper00005411
    WBPaper00005725
    WBPaper00006285
    WBPaper00006475
    WBPaper00010813
    WBPaper00015484
    WBPaper00017281
    WBPaper00017803
    WBPaper00018343
    WBPaper00018381
    WBPaper00022322
    WBPaper00022323
    WBPaper00022987
    WBPaper00023167
    WBPaper00023348
    WBPaper00024228
    WBPaper00025247
    WBPaper00027225
    WBPaper00027285
    WBPaper00027311
    WBPaper00027445
    WBPaper00031331
    WBPaper00038491
    WBPaper00049828
    WBPaper00050436
    WBPaper00055090
    WBPaper00059294
    WBPaper00060060
    WBPaper00060692
    WBPaper00061805
    WBPaper00064708
    WBPaper00065181
    WBPaper00065312
  Remark: sur-5 is located on a 8kb BamHI fragment that overlaps both K03A1 and R12E12. R12E12 also rescues ku74. The allele ku74 is a inframe deletion that deletes 295 n.t. of the sur-5 genomic sequence.
  Method: Gene