| WBGene00001824 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F13D11 |
| Identity | Version | 1 |
| | Name | CGC_name | hbl-1 | Person_evidence | WBPerson698 |
| | | Sequence_name | F13D11.2 |
| | | Molecular_name | F13D11.2a |
| | | | F13D11.2a.1 |
| | | | CE27956 |
| | | | F13D11.2b |
| | | | CE23646 |
| | | | F13D11.2b.1 |
| | | Other_name | lin-57 |
| | | | CELE_F13D11.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | hbl-1 |
| | DB_info | Database | WormQTL | gene | WBGene00001824 |
| | | | WormFlux | gene | WBGene00001824 |
| | | | NDB | locus_tag | CELE_F13D11.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001824|UniProtKB=Q9XYD3 |
| | | | | family | PTHR24392 |
| | | | NCBI | gene | 180848 |
| | | | RefSeq | protein | NM_001047778.5 |
| | | | | | NM_001047779.5 |
| | | | SwissProt | UniProtAcc | Q9XYD3 |
| | | | TREEFAM | TREEFAM_ID | TF326588 |
| | | | TrEMBL | UniProtAcc | Q27GU0 |
| | | | UniProt_GCRP | UniProtAcc | Q9XYD3 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hbl |
| | Allele (73) |
| | Possibly_affected_by | WBVar02152888 |
| | Strain (11) |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (32) |
| | Paralog | WBGene00016189 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00005009 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00003033 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008762 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00012385 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | hbl-1 encodes a C2H2-type zinc finger transcription factor related to Drosophila hunchback; hbl-1 is a heterochronic gene that plays an essential role in regulating developmental timing during postembryonic development; accordingly, mutations in hbl-1 affect locomotion, egg laying, body morphology, and hypodermal differentiation; hbl-1 is expressed in hypodermal precursor cells, neuronal precursor cells, and pharyngeal cells during embryogenesis and is primarily expressed in neurons during larval development; hbl-1 expression is negatively regulated by the let-7 miRNA whose expression is, in turn, negatively regulated by HBL-1 in a negative feedback loop. | Paper_evidence | WBPaper00003392 |
| | | | | | WBPaper00005908 |
| | | | | | WBPaper00005909 |
| | | | | | WBPaper00034754 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 20 Aug 2009 00:00:00 |
| | | Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and nematode larval development. Located in nucleus. Expressed in several structures, including body wall musculature; germ line; hypodermis; neurons; and ventral nerve cord. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F13D11.2a |
| | | F13D11.2b |
| | Corresponding_CDS_history | F13D11.2:wp155 |
| | Corresponding_transcript | F13D11.2a.1 |
| | | F13D11.2b.1 |
| | Other_sequence | JI462622.1 |
| | | JI164262.1 |
| | | Oden_isotig23540 |
| | | SC01112 |
| | | JI164529.1 |
| | | MI07402 |
| | | MIC06569_1 |
| | | GR977958.1 |
| | Associated_feature | WBsf019183 |
| | | WBsf019184 |
| | | WBsf019185 |
| | | WBsf019186 |
| | | WBsf019187 |
| | | WBsf019188 |
| | | WBsf019189 |
| | | WBsf019190 |
| | | WBsf019191 |
| | | WBsf019192 |
| | | WBsf019193 |
| | | WBsf019194 |
| | | WBsf662821 |
| | | WBsf662822 |
| | | WBsf662823 |
| | | WBsf662824 |
| | | WBsf662825 |
| | | WBsf662826 |
| | | WBsf662827 |
| | | WBsf662828 |
| | | WBsf662829 |
| | | WBsf662830 |
| | | WBsf716625 |
| | | WBsf716626 |
| | | WBsf718598 |
| | | WBsf978668 |
| | | WBsf1005398 |
| | | WBsf1005399 |
| | | WBsf1005400 |
| | | WBsf1005401 |
| | | WBsf1005402 |
| | | WBsf1005403 |
| | | WBsf1005404 |
| | | WBsf1023016 |
| | | WBsf1023017 |
| | | WBsf1023018 |
| | | WBsf1023019 |
| | | WBsf1023020 |
| | | WBsf1023021 |
| | | WBsf235756 |
| | | WBsf235757 |
| | | WBsf235758 |
| | | WBsf235759 |
| | Transcription_factor | WBTranscriptionFactor000175 |
| Experimental_info | RNAi_result (78) |
| | Expr_pattern (15) |
| | Drives_construct (11) |
| | Construct_product | WBCnstr00000374 |
| | | WBCnstr00009982 |
| | | WBCnstr00017352 |
| | | WBCnstr00019440 |
| | | WBCnstr00036665 |
| | Microarray_results (27) |
| | Expression_cluster | WBPaper00032031:DConiospora_upregulated_OligoArray_24h |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040285:H2S_12hr_downregulated |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00041222:unc-120(st364)_downregulated |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_4 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050843:sesamin_downregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:mir-71(n4115)_upregulated_mRNA |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00053771:up_at_24h-NaCl |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055981:fog-2(q71)_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056039:ptl-1(ok621)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059735:glucose_upregulated_N2 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060797:ahr-1(ju145)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SIB |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:hda-1(ne4748)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:F58E6.13_17427-ifa-3 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F3 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065199:Transgeneration-starvation_regulated_fed |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065841:1_0 |
| | | WBPaper00065841:1_1 |
| | | WBPaper00065841:1_2 |
| | | WBPaper00065841:91_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066093:E.coli-purE_downregulated |
| | | WBPaper00066204:CdCl2_downregulated_mRNA |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027342:alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041002:HF_11d_0.2mM_Up |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00050538:Fasting_upregulated_cholesterol-dependent |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (217) |
| | Anatomy_function | WBbtf0427 |
| | WBProcess | WBbiopr:00000083 |
| Map_info | Map | X | Position | -4.26909 | Error | 0.011372 |
| | Positive | Positive_clone | F13D11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4396 |
| | Pseudo_map_position |
| Reference (125) |
| Remark | Sequence connection from [Abrahante JE, Rougvie AE] |
| | old_name lin-57 becomes new_name hbl-1 from [Abrahante JE, Rougvie AE]. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
