WormBase Tree Display for Gene: WBGene00000939
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WBGene00000939 | Evidence | Paper_evidence | WBPaper00004772 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K12H4 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | dcr-1 | Person_evidence | WBPerson419 | |||||
Sequence_name | K12H4.8 | ||||||||
Molecular_name | K12H4.8 | ||||||||
K12H4.8.1 | |||||||||
CE47418 | |||||||||
Other_name (3) | |||||||||
Public_name | dcr-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | dcr | ||||||||
Allele | WBVar00402718 | ||||||||
WBVar00402719 | |||||||||
WBVar00402720 | |||||||||
WBVar00402721 | |||||||||
WBVar00402722 | |||||||||
WBVar00402723 | |||||||||
WBVar01500260 | |||||||||
WBVar00402724 | |||||||||
WBVar00402725 | |||||||||
WBVar00402726 | |||||||||
WBVar00402727 | |||||||||
WBVar00402728 | |||||||||
WBVar00402729 | |||||||||
WBVar00402730 | |||||||||
WBVar00242379 | |||||||||
WBVar00242392 | |||||||||
WBVar02152733 | |||||||||
WBVar00066765 | |||||||||
WBVar01983966 | |||||||||
WBVar01722982 | |||||||||
WBVar01499774 | |||||||||
WBVar00088953 | |||||||||
WBVar01645605 | |||||||||
WBVar01645606 | |||||||||
WBVar00066585 | |||||||||
WBVar01331434 | |||||||||
WBVar00239358 | |||||||||
WBVar00842668 | |||||||||
WBVar00842669 | |||||||||
WBVar01628893 | |||||||||
WBVar00842670 | |||||||||
WBVar01628894 | |||||||||
WBVar00842671 | |||||||||
WBVar01628895 | |||||||||
WBVar00842672 | |||||||||
WBVar01628896 | |||||||||
WBVar00842673 | |||||||||
WBVar00842674 | |||||||||
WBVar00842675 | |||||||||
WBVar01990204 | |||||||||
WBVar00842676 | |||||||||
WBVar01990205 | |||||||||
WBVar00842677 | |||||||||
WBVar00842678 | |||||||||
WBVar00842679 | |||||||||
WBVar00842680 | |||||||||
WBVar00842681 | |||||||||
WBVar00842682 | |||||||||
WBVar00842683 | |||||||||
WBVar00842684 | |||||||||
WBVar00842685 | |||||||||
WBVar00842686 | |||||||||
WBVar00842687 | |||||||||
WBVar00842688 | |||||||||
WBVar00602716 | |||||||||
WBVar00842689 | |||||||||
WBVar01607154 | |||||||||
WBVar00842690 | |||||||||
WBVar00842691 | |||||||||
WBVar00842692 | |||||||||
WBVar00842693 | |||||||||
WBVar01667482 | |||||||||
WBVar00842694 | |||||||||
WBVar00842695 | |||||||||
WBVar00842696 | |||||||||
WBVar00842697 | |||||||||
WBVar00296485 | |||||||||
WBVar00842698 | |||||||||
WBVar00842699 | |||||||||
WBVar00842700 | |||||||||
WBVar00842701 | |||||||||
WBVar00842702 | |||||||||
WBVar00842703 | |||||||||
WBVar00842704 | |||||||||
WBVar01266080 | |||||||||
WBVar00091550 | |||||||||
WBVar01447007 | |||||||||
WBVar00067508 | |||||||||
Legacy_information | Homozygous s2624 and s2795 each develope into sterile adults. | ||||||||
Strain (13) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (61) | |||||||||
Ortholog (58) | |||||||||
Paralog | WBGene00001090 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
WBGene00008400 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Structured_description | Concise_description | dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease. | Paper_evidence | WBPaper00004424 | |||||
WBPaper00004923 | |||||||||
WBPaper00005368 | |||||||||
WBPaper00036025 | |||||||||
WBPaper00024573 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 03 Feb 2014 00:00:00 | ||||||||
Automated_description | Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:4769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
DOID:0050745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
DOID:0080615 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
DOID:0050489 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
DOID:0081063 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
Molecular_info | Corresponding_CDS | K12H4.8 | |||||||
Corresponding_CDS_history | K12H4.8:wp230 | ||||||||
Corresponding_transcript | K12H4.8.1 | ||||||||
Other_sequence (58) | |||||||||
Associated_feature | WBsf651241 | ||||||||
WBsf667129 | |||||||||
WBsf227077 | |||||||||
WBsf227078 | |||||||||
Experimental_info | RNAi_result (65) | ||||||||
Expr_pattern | Expr10581 | ||||||||
Expr11565 | |||||||||
Expr12215 | |||||||||
Expr12472 | |||||||||
Expr1022725 | |||||||||
Expr1030586 | |||||||||
Expr1154395 | |||||||||
Expr2010807 | |||||||||
Expr2029044 | |||||||||
Drives_construct | WBCnstr00005999 | ||||||||
WBCnstr00006000 | |||||||||
WBCnstr00006001 | |||||||||
WBCnstr00017007 | |||||||||
WBCnstr00020414 | |||||||||
WBCnstr00037186 | |||||||||
Construct_product (13) | |||||||||
Regulate_expr_cluster | WBPaper00027057:DCR-1_interacting_adult | ||||||||
WBPaper00027057:DCR-1_interacting_embryo | |||||||||
WBPaper00029437:dcr-1_downregulated | |||||||||
WBPaper00029437:dcr-1_upregulated | |||||||||
WBPaper00059490:dcr-1(m9375)_downregulated | |||||||||
WBPaper00059490:dcr-1(m9375)_upregulated | |||||||||
Antibody | WBAntibody00000418 | ||||||||
WBAntibody00001054 | |||||||||
WBAntibody00001326 | |||||||||
WBAntibody00001327 | |||||||||
WBAntibody00001490 | |||||||||
WBAntibody00002257 | |||||||||
WBAntibody00002600 | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (137) | |||||||||
Interaction (219) | |||||||||
WBProcess | WBbiopr:00000014 | ||||||||
WBbiopr:00000039 | |||||||||
WBbiopr:00000057 | |||||||||
WBbiopr:00000073 | |||||||||
WBbiopr:00000081 | |||||||||
Map_info | Map | III | Position | -0.385999 | Error | 0.003601 | |||
Hide_under | WBGene00002843 | ||||||||
Positive | Inside_rearr | nDf20 | |||||||
sDp3 | |||||||||
sDp8 | |||||||||
Positive_clone | K12H4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Negative | Outside_rearr | sDf128 | |||||||
Mapping_data | Multi_point | 5311 | |||||||
Pos_neg_data | 9651 | ||||||||
9674 | |||||||||
9694 | |||||||||
9695 | |||||||||
9715 | |||||||||
Reference (124) | |||||||||
Remark | The let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508] | ||||||||
Method | Gene |