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WormBase Tree Display for Gene: WBGene00022816

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Name Class

WBGene00022816SMapS_parentSequenceCHROMOSOME_III
IdentityVersion3
NameCGC_namefbn-1Person_evidenceWBPerson545
WBPerson3379
WBPerson1983
Sequence_nameZK783.1
Molecular_name (27)
Other_namelet-821
cpg-16Paper_evidenceWBPaper00053350
CELE_ZK783.1Accession_evidenceNDBBX284603
Public_namefbn-1
DB_infoDatabaseAceViewgene3I729
WormQTLgeneWBGene00022816
WormFluxgeneWBGene00022816
OMIMdisease154700
gene134797
612570
NDBlocus_tagCELE_ZK783.1
PanthergeneCAEEL|WormBase=WBGene00022816|UniProtKB=I6Z0I7
familyPTHR24039
NCBIgene176076
RefSeqproteinNM_001276783.3
NM_001276787.4
NM_001276782.4
NM_001276789.4
NM_001276785.3
NM_001276780.3
NM_001276786.3
NM_066269.6
NM_001276788.3
TrEMBLUniProtAccI7J4C9
I7LFE6
I7K4J6
I7LHV9
I7J4C8
Q23587
I6Z0I7
I7K4J2
I7LHV8
UniProt_GCRPUniProtAccI6Z0I7
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:06WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
228 Jul 2005 14:07:57WBPerson2970Name_changeCGC_namefbn-1
320 May 2019 14:10:26WBPerson1983Name_changeCGC_namefbn-1
Other_namelet-821
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfbn
Allele (207)
StrainWBStrain00054908
RNASeq_FPKM (74)
GO_annotation00023935
00126798
Ortholog (39)
ParalogWBGene00003173Caenorhabditis elegansFrom_analysisPanther
WBGene00003482Caenorhabditis elegansFrom_analysisPanther
WBGene00003497Caenorhabditis elegansFrom_analysisPanther
WBGene00007170Caenorhabditis elegansFrom_analysisPanther
WBGene00001106Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00004963Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00009114Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00010134Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00013498Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00013855Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionfbn-1 encodes a protein homologous to the human extracellular matrix protein fibrillin-1 (FBN1); in C. elegans, fbn-1 activity is required for completion of molting, particularly the L3/L4 or L4/Adult molts.Paper_evidenceWBPaper00004103
WBPaper00026763
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated18 Jul 2007 00:00:00
Automated_descriptionPredicted to enable calcium ion binding activity. Predicted to be located in membrane. Expressed in vulval cell. Used to study connective tissue disease. Human ortholog(s) of this gene implicated in several diseases, including CREST syndrome; aortic disease (multiple); and bone disease (multiple). Is an ortholog of human FBN1 (fibrillin 1); FBN2 (fibrillin 2); and FBN3 (fibrillin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:65Homo sapiensPaper_evidenceWBPaper00046588
Curator_confirmedWBPerson324
Date_last_updated26 Oct 2018 00:00:00
Potential_model (13)
Disease_relevanceMutations in the human extracellular matrix protein fibrillin-1 (FBN1) lead to Marfan syndrome and several other disorders of connective tissue and skin; Both Marfan and Weill-Marchesani syndromes are characterized by abnormalities in connective tissue leading to heart, eye and skeletal abnormalities; FBN1 gene mutations also cause acromicric dysplasia characterized by severely short stature, short limbs and stiff joints; FBN1 gene mutations also cause MASS syndrome, involving abnormalities of the mitral heart valve, aorta, skeleton and skin; FBN1 gene mutations may also be involved in Shprintzen-Goldberg syndrome in infants which involves premature fusion of certain bones of the skull, and skeletal and skin abnormalities; in elegans mutations in fbn-1/fibrillin1 cause defects in molting.Homo sapiensPaper_evidenceWBPaper00026763
Accession_evidenceOMIM154700
134797
Curator_confirmedWBPerson324
Date_last_updated09 Dec 2013 00:00:00
Models_disease_assertedWBDOannot00000253
Molecular_infoCorresponding_CDSZK783.1a
ZK783.1b
ZK783.1d
ZK783.1e
ZK783.1f
ZK783.1g
ZK783.1h
ZK783.1j
ZK783.1k
Corresponding_CDS_historyZK783.1:wp206
ZK783.1i:wp275
Corresponding_transcriptZK783.1a.1
ZK783.1b.1
ZK783.1d.1
ZK783.1e.1
ZK783.1f.1
ZK783.1g.1
ZK783.1h.1
ZK783.1j.1
ZK783.1k.1
Other_sequence (20)
Associated_feature (22)
Experimental_infoRNAi_result (22)
Expr_patternExpr15951
Expr1025080
Expr1040095
Expr1163127
Expr2011446
Expr2029684
Drives_constructWBCnstr00042617
Construct_productWBCnstr00014819
WBCnstr00042617
Microarray_results (30)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00032528:L3_enriched
WBPaper00035197:fer-1_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040285:H2S_12hr_downregulated
WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
WBPaper00042561:smg-2(RNAi)_downregulated
WBPaper00042561:smgl-1(RNAi)_downregulated
WBPaper00043945:MeHg_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044426:rotenone_5day_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045420:fertilization_downregulated_protein
WBPaper00045521:Gender_Neutral
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046024:sleep_downregulated_oscillating
WBPaper00046121:ecdoderm_unique
WBPaper00046499:AMPK_regulated
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00046805:csr-1(RNAi)_downregulated_Set2
WBPaper00046887:WNT-target
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00048690:gonad-hermaphrodite-biased
WBPaper00048988:neuron_expressed
WBPaper00049098:heat-induced_hrde-1(tm1200)
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049594:osm-9(ok1677)_NaCl(200mM)_upregulate
WBPaper00049594:osm-9(ok1677)_upregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050193:cec-4(ok3124)_downregulated_L1
WBPaper00050193:dpy-27(RNAi)_downregulated_L1
WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050903:mir-35-41(nDf50)_25C_downregulated
WBPaper00050990:body-muscle_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00051021:4-bromodiphenyl-ether_downregulated
WBPaper00051305:vit-2(ac3)_upregulated
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00051371:Orsay-virus-infection_upregulated_rde-1(ne219)
WBPaper00051558:aging_regulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053402:his-3(RNAi)_upregulated
WBPaper00053657:N2_M.humicola-infection_24hr
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:sod-2(ok1030)_upregulated
WBPaper00053814:15C_downregulated_OP50
WBPaper00054192:cold-shock_downregulated
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055013:hmg-4(RNAi)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055386:eat-2(ad465)_downregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00055969:electromagnetic-field_downregulated
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00056039:ptl-1(ok621)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056169:rrf-3(pk1426)_upregulated_L1
WBPaper00056169:rrf-3(pk1426)_upregulated_L3
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056330:glycine_downregulated
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056446:hsb-1(cg116)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056617:adr-1_upregulated_L4_transcript
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
WBPaper00057149:prgn-1(tm985)_downregulated
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057265:metaformin_upregulated_OP50
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00057347:nhr-14(tm1473)_downreglated
WBPaper00058648:Y37A1B.5(RNAi)_downregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00058948:npr-8(ok1439)_upregulated_OP50
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059224:tph-1(mg280)_upregulated
WBPaper00059231:alh-6(lax105)_D3Adult_downregulated
WBPaper00059231:alh-6(lax105)_L4_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
WBPaper00059739:hira-1(gk835598)_upregulated_L4
WBPaper00059754:C.neoformans_H99_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060224:atf-6(ok551)_upregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060273:vrk-1(RNAi)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
WBPaper00060445:ikb-1(nr2027)_downregulated_L4
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060445:nfki-1(cer1)_downregulated_L4
WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:HB101_upregulated
WBPaper00061007:HB115_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:F_U
WBPaper00061340:G2_and_W_blasts
WBPaper00061340:hyp4_hyp5_hyp6
WBPaper00061340:hyp7_AB_lineage
WBPaper00061340:hyp7_C_lineage
WBPaper00061340:K_Kprime
WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
WBPaper00061340:P_cell
WBPaper00061340:T
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061405:S.aureus_downregulated_starvation
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4747)_upregulated
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:mlt-9_22518-F33D4.6_14044
WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
WBPaper00061699:daf-18(ok480)_upregulated
WBPaper00062156:jmjd-5(zr1234)_upregulated
WBPaper00062193:daf-16(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062237:dnj-21(RNAi)_upregulated_protein
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062446:nhr-8(ok186)_upregulated
WBPaper00062456:doxycycline_upregulated_N2_protein
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062534:fat-P-80_downregulated
WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
WBPaper00064005:starvation_downregulated_N2_protein
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064156:lipl-4(overexpress)_downregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064403:Heat-killed-E.Coli_upregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064769:him-17(me24)_downregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00064999:miR-229-64-65-66_upregulated
WBPaper00065029:cadmium_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065086:N2_N.ironsii_regulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
WBPaper00065315:mating_upregulated_Day2-7
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065392:Lb.gasseri_downregulated
WBPaper00065560:E.coli-HB101_downregulated_F3
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065841:1_0
WBPaper00065841:13_0
WBPaper00065841:13_1
WBPaper00065841:30_1
WBPaper00065841:57_0
WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066004:tdp-1(csb38)_upregulated
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4386_cluster_6_1
cgc4489_group_11
cgc4489_group_20
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026952:class_F
WBPaper00029437:dcr-1_upregulated
WBPaper00030985:Enterococcus_faecalis_downregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00031832:slr-2_regulated
WBPaper00032948:FedUp
WBPaper00034739:N2lessDR1350
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_E
WBPaper00036383:ash-2_Day8_regulated
WBPaper00038172:crh-1null_up_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038304:octr-1_regulated
WBPaper00039866:ClassComp_daf-19_upregulated
WBPaper00039866:SAM_daf-19_upregulated
WBPaper00040185:nhr-23(RNAi)_downregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00045960:L4-lethargus_downregulated
WBPaper00046548:dafachronic-acid_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
WBPaper00056330:mrps-5(RNAi)_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc6390]:Cluster_B
Interaction (23)
Map_infoMapIIIPosition-0.655224Error0.002689
PositivePositive_cloneZK783Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5355
4789
Pseudo_map_position
Reference (19)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene