WormBase Tree Display for Gene: WBGene00003497
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| WBGene00003497 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K07D8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mup-4 | Person_evidence | WBPerson1052 | |||||
| Sequence_name | K07D8.1 | ||||||||
| Molecular_name | K07D8.1 | ||||||||
| K07D8.1.1 | |||||||||
| CE29511 | |||||||||
| Other_name | CELE_K07D8.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mup-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mup | ||||||||
| Allele (135) | |||||||||
| Legacy_information | [Gatewood B, Bucher EA] mg36 is lethal, abnormal muscle positioning. | ||||||||
| [C.elegansII] mg36 : lethal, embryonic arrest at 3-fold, defective muscle attachment, abnormal hypodermis; muscle cells collapse from ventral side, retract from head and tail; some embryos arrested earlier. Mosaic analysis indicates focus in AB. OA>5: ar60, mg23, mg36, s2433 etc. [BC; EE; GR] | |||||||||
| [Stewart HI, Chamberlin HM] Homozygous s2433 arrest at a mid larval stage. | |||||||||
| Strain | WBStrain00034476 | ||||||||
| WBStrain00034477 | |||||||||
| WBStrain00034478 | |||||||||
| WBStrain00034484 | |||||||||
| WBStrain00037015 | |||||||||
| WBStrain00000754 | |||||||||
| WBStrain00006653 | |||||||||
| WBStrain00007984 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | The mup-4 gene encodes a novel transmembrane protein required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. | Paper_evidence | WBPaper00002771 | |||||
| WBPaper00004798 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Located in hemidesmosome. Part of hemidesmosome associated protein complex. Expressed in body wall musculature; hypodermis; pharynx; touch receptor neurons; and vulval cell. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5 and osteoarthritis. Is an ortholog of human MATN2 (matrilin 2) and MATN3 (matrilin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6909) | ||||
| DOID:0070299 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6909) | ||||||
| DOID:8398 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6909) | ||||||
| Molecular_info | Corresponding_CDS | K07D8.1 | |||||||
| Corresponding_transcript | K07D8.1.1 | ||||||||
| Other_sequence (20) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (41) | ||||||||
| Expr_pattern | Expr1626 | ||||||||
| Expr15945 | |||||||||
| Expr1023788 | |||||||||
| Expr1031600 | |||||||||
| Expr1153857 | |||||||||
| Expr2013826 | |||||||||
| Expr2032066 | |||||||||
| Drives_construct | WBCnstr00004800 | ||||||||
| WBCnstr00007539 | |||||||||
| WBCnstr00010356 | |||||||||
| WBCnstr00036086 | |||||||||
| Construct_product | WBCnstr00007539 | ||||||||
| WBCnstr00010356 | |||||||||
| WBCnstr00036086 | |||||||||
| Antibody | WBAntibody00000390 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (263) | |||||||||
| Interaction (32) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | III | Position | -0.729766 | Error | 0.000597 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | K07D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Outside_rearr | nDf20 | |||||||
| Mapping_data | Multi_point | 3191 | |||||||
| 3192 | |||||||||
| 4013 | |||||||||
| 4014 | |||||||||
| 4214 | |||||||||
| Pos_neg_data | 8681 | ||||||||
| 8707 | |||||||||
| 8710 | |||||||||
| 8722 | |||||||||
| 8805 | |||||||||
| 8814 | |||||||||
| 9708 | |||||||||
| Reference (36) | |||||||||
| Remark | Moved from -0.739 [sdm/jah 5/99] | ||||||||
| The mutation s2833 was previously assigned to let-794. | |||||||||
| Sequence connection from [Gatewood BK, Bucher EA] | |||||||||
| Method | Gene |
