WormBase Tree Display for Gene: WBGene00022642

WBGene00022642 SMap: S_parent: Sequence: ZK6
  Identity: Version: 2
    Name: CGC_name: lipl-5 Person_evidence: WBPerson3759
            WBPerson7490
            WBPerson545
      Sequence_name: ZK6.7
      Molecular_name: ZK6.7a
        ZK6.7a.1
        CE18444
        ZK6.7c
        CE50798
        ZK6.7d
        CE50743
        ZK6.7b
        ZK6.7c.1
        ZK6.7d.1
      Other_name: CELE_ZK6.7 Accession_evidence: NDB BX284605
      Public_name: lipl-5
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:06 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 19 Jul 2010 13:43:13 WBPerson2970 Name_change: CGC_name: lipl-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lipl
    Allele (47)
    Strain: WBStrain00033248
      WBStrain00037811
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00056760 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00024619 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00031836 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00140137 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00124528 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00155936 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00095900 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00096201 Pristionchus pacificus From_analysis: OMA
      WBGene00118375 Pristionchus pacificus From_analysis: OMA
      CBOVI.g1697 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g69 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g70 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3031 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7212 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g19215 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11822 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g13717 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g17218 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g3418 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g6354 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00874.g14693 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g17682 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold559.g3848 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01322.g20096 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_02662 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_020096 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_50015900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g12983 Caenorhabditis elegans From_analysis: WormBase-Compara
      SGD:S000003935 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
      SGD:S000001623 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      FB:FBgn0031533 Drosophila melanogaster From_analysis: OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0032265 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0051872 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0043825 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0051871 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
      FB:FBgn0033999 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0034990 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0038067 Drosophila melanogaster From_analysis: OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0038068 Drosophila melanogaster From_analysis: OMA
            OrthoFinder
            Panther
      FB:FBgn0038069 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0023495 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0024740 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-040426-2737 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6617 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6622 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:21773 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:23455 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:23444 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:23452 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:96789 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1914967 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1917416 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1926003 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2679259 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3647308 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2147592 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3779637 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3647649 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3644466 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:3008 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:708441 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1309724 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1565682 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1304912 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1560354 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2321667 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00008510 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009773 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010062 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00013050 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019376 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020016 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00021963 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: lipl-5 encodes a lipase; lipl-5 is expressed in the intestine and its expression is negatively regulated in well-fed animals by MXL-3; lipl-5 expression is induced upon bacterial infection. Paper_evidence: WBPaper00005382
            WBPaper00042295
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jun 2013 00:00:00
      Automated_description: Predicted to enable hydrolase activity, acting on ester bonds. Involved in defense response to Gram-negative bacterium; lipid homeostasis; and triglyceride catabolic process. Located in lysosome. Expressed in coelomocyte and intestine. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Is an ortholog of several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:14502 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:14497 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:0060717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23452)
  Molecular_info: Corresponding_CDS: ZK6.7a
      ZK6.7c
      ZK6.7d
    Corresponding_CDS_history: ZK6.7b:wp248
    Corresponding_transcript: ZK6.7b
      ZK6.7a.1
      ZK6.7c.1
      ZK6.7d.1
    Other_sequence (34)
    Associated_feature: WBsf999148
      WBsf1019064
      WBsf231319
      WBsf231320
      WBsf231321
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr1967
      Expr14545
      Expr14546
      Expr1010508
      Expr1162960
      Expr2013207
      Expr2031439
    Drives_construct: WBCnstr00041084
    Construct_product: WBCnstr00041084
    Microarray_results (23)
    Expression_cluster (289)
    Interaction (38)
    WBProcess: WBbiopr:00000039
  Map_info: Map: V Position: -20
    Positive: Positive_clone: ZK6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005382
    WBPaper00029387
    WBPaper00038491
    WBPaper00042257
    WBPaper00042295
    WBPaper00042442
    WBPaper00044217
    WBPaper00055090
    WBPaper00057084
    WBPaper00058799
    WBPaper00059755
    WBPaper00062456
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene