| WBGene00022199 | SMap | S_parent | Sequence | Y71H10A |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | pfk-1.1 | Person_evidence | WBPerson3194 |
| | | Sequence_name | Y71H10A.1 |
| | | Molecular_name | Y71H10A.1a |
| | | | Y71H10A.1a.1 |
| | | | CE28266 |
| | | | Y71H10A.1b |
| | | Other_name | pfk-1 | Person_evidence | WBPerson261 |
| | | | CELE_Y71H10A.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | pfk-1.1 |
| | DB_info | Database (14) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 28 Sep 2012 14:29:00 | WBPerson2970 | Name_change | CGC_name | pfk-1 |
| | | | 3 | 03 Mar 2014 14:12:13 | WBPerson2970 | Name_change | CGC_name | pfk-1.1 |
| | | | | | | | Other_name | pfk-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pfk |
| | Allele (73) |
| | RNASeq_FPKM (74) |
| | GO_annotation (33) |
| | Ortholog (58) |
| | Paralog | WBGene00008230 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | pfk-1.1 encodes two isoforms of a 6-phosphofructokinase (E.C. 2.7.1.11), paralogous to PFK-1.2; pfk-1.1 is an essential gene, and expressed in proximal germline and in several larval and adult tissues (including neurons, hypodermis, and pharyngeal muscle). | Paper_evidence | WBPaper00004651 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00025054 |
| | | | | | WBPaper00027758 |
| | | | | | WBPaper00028588 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 24 Feb 2014 00:00:00 |
| | | Automated_description | Predicted to enable several functions, including 6-phosphofructokinase activity; carbohydrate derivative binding activity; and identical protein binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Expressed in germ line; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is an ortholog of human PFKL (phosphofructokinase, liver type) and PFKM (phosphofructokinase, muscle). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:11721 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8877) |
| Molecular_info | Corresponding_CDS | Y71H10A.1a |
| | Corresponding_CDS_history | Y71H10A.1b:wp129 |
| | | Y71H10A.1b:wp245 |
| | Corresponding_transcript | Y71H10A.1b |
| | | Y71H10A.1a.1 |
| | Other_sequence (124) |
| | Associated_feature | WBsf718535 |
| | | WBsf1004484 |
| | | WBsf235423 |
| | | WBsf235424 |
| | | WBsf235425 |
| Experimental_info | RNAi_result | WBRNAi00021365 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001724 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00037787 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00058226 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00023148 |
| | | WBCnstr00042042 |
| | Construct_product | WBCnstr00042042 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00028451:Abundant_spermatogenesis_enriched |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044128:daf-2(e1370)_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045314:S.aureus-induced_hlh-30(tm1978) |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045729:gld-2(RNAi)_upregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051352:Long-Term-Association-Memory_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059203:CAR-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:sec-24.1_3187-F07F6.4 |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | cgc4489_group_24 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_124 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00027758:Group_II |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00037695:WC_CC_6-day |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042128:gei-8(ok1671)_upregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (92) |
| Map_info | Map | X | Position | -12.6701 |
| | Positive | Positive_clone | Y71H10A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (16) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
