WormBase Tree Display for Gene: WBGene00021415

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WBGene00021415	SMap	S_parent	Sequence	Y38F2AL
	Identity	Version	2
		Name	CGC_name	nsy-4	Paper_evidence	WBPaper00028384
					Person_evidence	WBPerson42
			Sequence_name	Y38F2AL.1
			Molecular_name	Y38F2AL.1
				Y38F2AL.1.1
				CE42187
				Y38F2AL.1.2
				Y38F2AL.1.3
			Other_name	Y38F2AL.h	Curator_confirmed	WBPerson1983
					Remark	Old cosmid naming mapped via unique overlapping PCR_product on CDSs
				CELE_Y38F2AL.1	Accession_evidence	NDB	BX284604
			Public_name	nsy-4
		DB_info	Database	AceView	gene	4D91
				WormQTL	gene	WBGene00021415
				WormFlux	gene	WBGene00021415
				NDB	locus_tag	CELE_Y38F2AL.1
				Panther	gene	CAEEL\|WormBase=WBGene00021415\|UniProtKB=Q9N419
					family	PTHR10671
				NCBI	gene	177019
				RefSeq	protein	NM_067788.9
				TREEFAM	TREEFAM_ID	TF316179
				TrEMBL	UniProtAcc	Q9N419
				UniProt_GCRP	UniProtAcc	Q9N419
		Species	Caenorhabditis elegans
		History	Version_change	1	28 May 2004 13:31:04	WBPerson1971	Event	Imported	Initial conversion from CDS class of stlace from WS125
				2	08 Sep 2006 10:43:24	WBPerson1847	Name_change	CGC_name	nsy-4
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	nsy
		Allele (88)
		Strain	WBStrain00036701
			WBStrain00005274
		RNASeq_FPKM (74)
		GO_annotation (14)
		Ortholog (30)
		Paralog	WBGene00000522	Caenorhabditis elegans	From_analysis	Panther
			WBGene00000523	Caenorhabditis elegans	From_analysis	Panther
			WBGene00000526	Caenorhabditis elegans	From_analysis	Panther
			WBGene00010742	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00016706	Caenorhabditis elegans	From_analysis	Panther
			WBGene00016067	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	nsy-4 encodes a member of the PMP22/EMP/claudin/calcium channel gamma subunit family; nsy-4 is worm-specific, with obvious homologs only in C. elegans; nsy-4 functions with nsy-5 to induce the AWC chemosensory neuron ON fate by regulating the activity of the UNC-2/UNC-36 calcium channel.	Paper_evidence	WBPaper00004651
						WBPaper00004961
						WBPaper00005654
						WBPaper00005946
						WBPaper00005975
						WBPaper00012856
						WBPaper00028384
						WBPaper00039831
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	01 Oct 2012 00:00:00
			Automated_description	Enables calcium channel inhibitor activity and protein kinase inhibitor activity. Involved in determination of left/right asymmetry in nervous system. Located in plasma membrane and plasma membrane bounded cell projection. Expressed in anterior hypodermis; blast cell; excretory cell; neurons; and tail hypodermis.	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	Y38F2AL.1
		Corresponding_CDS_history	Y38F2AL.1:wp122
			Y38F2AL.1:wp154
			Y38F2AL.1:wp187
		Corresponding_transcript	Y38F2AL.1.1
			Y38F2AL.1.2
			Y38F2AL.1.3
		Other_sequence (29)
		Associated_feature (12)
	Experimental_info	RNAi_result	WBRNAi00027517	Inferred_automatically	RNAi_primary
			WBRNAi00110922	Inferred_automatically	RNAi_primary
			WBRNAi00026658	Inferred_automatically	RNAi_primary
			WBRNAi00026657	Inferred_automatically	RNAi_primary
			WBRNAi00001055	Inferred_automatically	RNAi_primary
			WBRNAi00078922	Inferred_automatically	RNAi_primary
			WBRNAi00056041	Inferred_automatically	RNAi_primary
			WBRNAi00020299	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr12443
			Expr12444
			Expr1021400
			Expr1039353
			Expr1159564
			Expr2014507
			Expr2032746
		Drives_construct	WBCnstr00021104
		Construct_product	WBCnstr00006463
			WBCnstr00021103
		Microarray_results (20)
		Expression_cluster	WBPaper00033065:cyc-1(RNAi)_upregulated
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:hypodermis_larva_enriched
			WBPaper00037950:hypodermis_larva_SelectivelyEnriched
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
			WBPaper00044260:1-methylnicotinamide_downregulated
			WBPaper00044260:nicotic-acid_downregulated
			WBPaper00044426:rotenone_24h_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
			WBPaper00045417:128Q-huntingtin_downreglated
			WBPaper00045521:Gender_Neutral
			WBPaper00045934:wrn-1(gk99)_upregulated
			WBPaper00046121:ecdoderm_unique
			WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
			WBPaper00047131:daf-2(e1370)_upregulated_N2-background
			WBPaper00048690:gonad-male-biased
			WBPaper00048988:neuron_expressed
			WBPaper00049217:TCER-1_downregulated
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
			WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
			WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
			WBPaper00050370:dpy-21(e428)_L3_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
			WBPaper00050496:unc-39(hp701)_regulated
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00051245:epidermis_cytoplasm_expressed
			WBPaper00051245:epidermis_specific
			WBPaper00051352:Long-Term-Association-Memory_upregulated
			WBPaper00051404:alg-1(gk214)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053302:stavudine_72h_regulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053321:PGCs_depleted_NuGen
			WBPaper00053388:dauer_regulated_Cluster3
			WBPaper00053771:up_at_24h-NaCl
			WBPaper00053771:up_at_dpy-7(e88)
			WBPaper00053810:daf-2(e1370)_upregulated
			WBPaper00054758:alg-1(gk204)_upregulated
			WBPaper00055354:eat-2(ad1116)_upregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
			WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
			WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
			WBPaper00055354:Rapamycin-Rifampicin_upregulated
			WBPaper00055354:Rifampicin-Allantoin_upregulated
			WBPaper00055354:Rifampicin-Psora_upregulated
			WBPaper00055354:Rifampicin_upregulated
			WBPaper00055386:daf-2(e1370)_upregulated
			WBPaper00055482:pmt-2(RNAi)_upregulated
			WBPaper00055971:nhl-2(ok818)_25C_downregulated
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056090:E.faecalis_upregulated_N2
			WBPaper00056139:soil-microbiota_upregulated
			WBPaper00056165:MINA-1_interacting_mRNA
			WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
			WBPaper00056284:ints-1(RNAi)_downregulated
			WBPaper00056330:glycine_downregulated
			WBPaper00056443:sek-1(km4)_upregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
			WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
			WBPaper00057288:iff-1(RNAi)_upregulated_transcript
			WBPaper00057347:nhr-14(tm1473)_downreglated
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058958:100mGy-irradiation-72h_upregulated
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
			WBPaper00059421:daf-3(mgDf90)_downregulated
			WBPaper00059471:EGL-43_interacting
			WBPaper00059605:mut-16(pk710)_upregulated
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00059739:hira-1(gk835598)_upregulated_adult
			WBPaper00059895:wounding_upregulated
			WBPaper00059987:Wounding_upregulated
			WBPaper00060014:set-2(tm1630)_downregulated
			WBPaper00060273:isp-1(qm150)_upregulated
			WBPaper00060661:sensory-neuron_enriched
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00061007:HB101_upregulated
			WBPaper00061007:S.aquatilis_upregulated
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061274:hypergravity_15xg_upregulated
			WBPaper00061340:ADEsh
			WBPaper00061340:AMsh
			WBPaper00061340:B
			WBPaper00061340:B_F_K_Kp_U_Y
			WBPaper00061340:CEPsh
			WBPaper00061340:Excretory_duct_and_pore
			WBPaper00061340:F_U
			WBPaper00061340:G2_and_W_blasts
			WBPaper00061340:Glia
			WBPaper00061340:hyp3
			WBPaper00061340:hyp4_hyp5_hyp6
			WBPaper00061340:hyp7_AB_lineage
			WBPaper00061340:P_cell
			WBPaper00061340:Rectal_cell
			WBPaper00061340:Seam_cell
			WBPaper00061340:T
			WBPaper00061340:Tail_hypodermis
			WBPaper00061340:Y
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061439:unc-30(ok613)_upregulated
			WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
			WBPaper00061479:mep-1(ne4629)_upregulated
			WBPaper00061479:ubc-9(ne4833)_upregulated
			WBPaper00061527:R07G3.8_9125-ric-4_17408
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062184:PA14_downregulated
			WBPaper00062193:skn-1(RNAi)_upregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062440:crh-1(n3315)_downregulated
			WBPaper00062554:MAGU-2_interacting
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064306:Agaro-oligosaccharides_upregulated
			WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
			WBPaper00064716:paraquat_downregulated
			WBPaper00065029:cadmium_upregulated
			WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
			WBPaper00065331:100nM-ivermectin_downregulated
			WBPaper00065560:E.coli-HB101_downregulated_F3
			WBPaper00065581:hpk-1(pk1393)_upregulated
			WBPaper00065749:endu-2(tm4977)_upregulated
			WBPaper00065841:5_0
			WBPaper00065841:5_1
			WBPaper00065841:30_2
			WBPaper00065841:34_0
			WBPaper00065841:37_0
			WBPaper00065841:64_0
			WBPaper00065841:82_1
			WBPaper00065841:141_0
			WBPaper00066110:tetraploid_vs_diploid_upregulated
			WBPaper00066232:ash-2(RNAi)_upregulated_WT
			cgc4386_cluster_6_4
			cgc4489_group_14
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00029437:dcr-1_upregulated
			WBPaper00030985:Serratia_marcesens_upregulated
			WBPaper00031003:0hr_muscle_depleted
			WBPaper00031003:24hr_muscle_depleted
			WBPaper00031003:total_muscle_depleted
			WBPaper00031532:Larva_Pan_Neuronal_Depleted
			WBPaper00035227:heat_shock_regulated
			WBPaper00035873:dpy-9_regulated
			WBPaper00036130:mir-243_up_regulated
			WBPaper00036286:Pattern_G
			WBPaper00037695:LD_3-day
			WBPaper00038172:crh-1null_up_regulated
			WBPaper00039866:ClassComp_daf-19_upregulated
			WBPaper00040210:Chlorpyrifos_24C_regulated
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00040858:eQTL_age_regulated_developing
			WBPaper00040858:eQTL_regulated_developing
			WBPaper00040858:eQTL_regulated_juvenile
			WBPaper00040963:Q100_down
			WBPaper00040963:Q200_down
			WBPaper00041002:HF_11d_0.2mM_Up
			WBPaper00041174:genotypic
			WBPaper00041174:genotypic_prime
			WBPaper00045673:colistin_upregulated
			WBPaper00047070:N2_UV_upregulated
			WBPaper00047070:xpa-1_UV_upregulated
			WBPaper00048989:N2_rapamycin_upregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00053236:Starvation_regulated_N2
			WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc5767]:expression_class_E
			[cgc5767]:expression_class_ET
			[cgc5767]:expression_class_ET_max(101_min)
			[cgc5767]:expression_class_E_pi(53_min)
			[cgc5767]:expression_class_SE
			[cgc5767]:expression_class_SET
			[cgc5767]:expression_class_SE_pi(53_min)
			[cgc6390]:Cluster_B
		Interaction	WBInteraction000008904
			WBInteraction000052103
			WBInteraction000052104
			WBInteraction000518739
		Anatomy_function	WBbtf0519
			WBbtf0520
			WBbtf0521
			WBbtf0522
			WBbtf0523
	Map_info	Map	IV	Position	-7.97649	Error	0.047532
		Positive	Positive_clone	Y38F2AL	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference (15)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene