WormBase Tree Display for Gene: WBGene00020757

WBGene00020757 SMap: S_parent: Sequence: T24C4
  Identity: Version: 2
    Name: CGC_name: ucr-2.3 Paper_evidence: WBPaper00027699
      Sequence_name: T24C4.1
      Molecular_name: T24C4.1
        T24C4.1.1
        CE19592
      Other_name: CELE_T24C4.1 Accession_evidence: NDB BX284603
      Public_name: ucr-2.3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 27 Jul 2006 17:15:46 WBPerson2970 Name_change: CGC_name: ucr-2.3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ucr
    Allele (41)
    Strain: WBStrain00028976
      WBStrain00037284
    RNASeq_FPKM (74)
    GO_annotation: 00097798
      00097799
      00097800
      00105868
      00125328
    Ortholog (37)
    Paralog: WBGene00011679 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012158 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015481 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013492 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013880 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015360 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018426 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018963 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022159 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: T24C4.1 encodes an ubiquinol-cytochrome C reductase complex core protein 2 ortholog, predicted by Eisenberg and coworkers to be mitochondrial, and required for germline maintenance in mass RNAi assays. Paper_evidence: WBPaper00004424
            WBPaper00005599
            WBPaper00006395
          Curator_confirmed: WBPerson567
          Date_last_updated: 18 Jul 2005 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Involved in protein folding. Predicted to be located in mitochondrial matrix. Expressed in neurons and pharyngeal gland cell. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Is an ortholog of human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080114 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12586)
  Molecular_info: Corresponding_CDS: T24C4.1
    Corresponding_transcript: T24C4.1.1
    Other_sequence (26)
    Associated_feature: WBsf644932
      WBsf224413
      WBsf224414
      WBsf224415
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr10186
      Expr1018565
      Expr1039037
      Expr1157577
      Expr2017740
      Expr2035879
    Drives_construct: WBCnstr00024910
    Construct_product: WBCnstr00024910
    Antibody: WBAntibody00001108
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_lin-35
      WBPaper00035073:mitochondria_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037086:biotin_regulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038168:lin-35_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044128:daf-2(e1370)_downregulated
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-4(RNAi)_downregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048644:germline_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050193:lsm-1(tm3585)_upregulated_L3
      WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00054913:AKIR-1_interacting_protein
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_downregulated_embryo
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057254:MWCNT_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058598:spn-4(tm291)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059254:PRG-1_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:Germline
      WBPaper00061340:PLM
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00062056:dpl-1(n2994)_upregulated
      WBPaper00062056:lin-15B(n744)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-37(n758)_upregulated
      WBPaper00062056:met-2(n4256)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064107:lin-52(3A)_vs_lin-52(WT)_upregulated
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064315:mes-4(bn73)_downregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065841:3_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_25
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_143
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00035227:heat_shock_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_H
      WBPaper00036429:glp-1(oz112)_upregulated
      WBPaper00037695:LD_DD_6-day
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00038427:lin-54_germline_changed
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00051387:Triclosan_downregulated
      [cgc5767]:cluster_36
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (275)
  Map_info: Map: III Position: -25.5236 Error: 0.024714
    Positive: Positive_clone: T24C4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027699
    WBPaper00030701
    WBPaper00031194
    WBPaper00038491
    WBPaper00040537
    WBPaper00041750
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene