WormBase Tree Display for Gene: WBGene00017571

WBGene00017571 SMap: S_parent: Sequence: F18E9
  Identity: Version: 3
    Name: CGC_name: jmjd-3.1 Person_evidence: WBPerson1422
      Sequence_name: F18E9.5
      Molecular_name: F18E9.5a
        F18E9.5a.1
        CE30957
        F18E9.5b
        CE30958
        F18E9.5a.2
        F18E9.5a.3
        F18E9.5b.1
      Other_name: tag-279
        CELE_F18E9.5 Accession_evidence: NDB BX284606
      Public_name: jmjd-3.1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 30 Sep 2011 16:40:15 WBPerson2970 Name_change: CGC_name: jmjd-3.1
        3 08 Aug 2016 09:53:25 WBPerson2970 Name_change: Other_name: tag-279
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: jmjd
    Allele: WBVar02159258
      WBVar01168532
      WBVar01168533
      WBVar01168534
      WBVar01168535
      WBVar01168536
      WBVar01168537
      WBVar01168538
      WBVar01168539
      WBVar01168540
      WBVar01168541
      WBVar01168542
      WBVar01168543
      WBVar01168544
      WBVar01168545
      WBVar02065219
      WBVar01168546
      WBVar01168547
      WBVar01168548
      WBVar01168549
      WBVar01168550
      WBVar00510940
      WBVar00510941
      WBVar00510942
      WBVar00510943
      WBVar00510944
      WBVar00510945
      WBVar00510946
      WBVar00510947
      WBVar00510948
      WBVar00510949
      WBVar00510950
      WBVar00510951
      WBVar00510952
      WBVar00510953
      WBVar00510954
      WBVar00510955
      WBVar01816240
      WBVar01816241
      WBVar01816242
      WBVar00054636
      WBVar01816243
      WBVar00054641
      WBVar01470202
      WBVar01470203
      WBVar00054651
      WBVar00054656
      WBVar00054661
      WBVar01499963
      WBVar01499781
      WBVar01491150
      WBVar01500168
      WBVar01500169
      WBVar01499265
      WBVar01499642
      WBVar01885637
      WBVar01885638
      WBVar01885639
      WBVar00145790
      WBVar02052600
      WBVar00145793
      WBVar01690184
      WBVar01168508
      WBVar01168509
      WBVar01168510
      WBVar01168511
      WBVar01168512
      WBVar01168513
      WBVar01168514
      WBVar01550722
      WBVar01168515
      WBVar01168516
      WBVar01168517
      WBVar01782402
      WBVar01168518
      WBVar01168519
      WBVar01168520
      WBVar01168521
      WBVar01168522
      WBVar01168523
      WBVar01168524
      WBVar01168525
      WBVar02141074
      WBVar01168526
      WBVar01168527
      WBVar02141075
      WBVar01168528
      WBVar02141076
      WBVar01498960
      WBVar01168529
      WBVar02141077
      WBVar01168530
      WBVar01500067
      WBVar01168531
    Strain: WBStrain00036167
      WBStrain00036185
      WBStrain00040876
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (34)
    Paralog: WBGene00007813 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00009089 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00017046 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: jmjd-3.1 encodes, by alternative splicing, two isoforms of a histone H3 trimethyllysine-27 (H3K27me3) demethylase that is required for normal gonad migration and organization; JMJD-3.1 demethylates H3K27me3 in vitro; JMJD-3.1 contains an N-terminal TonB domain and a C-terminal JmjC domain, and is homologous to human JMJD3, UTX (OMIM:300128), and UTY (OMIM:400009); null jmjd-3.1(gk384) and jmjd-3.1(gk387) mutants have aberrant gonad migration and disordered diakinesis-phase oocytes, phenotypes enhanced at 25 deg. C.; JMJD-3.1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes. Paper_evidence: WBPaper00030964
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 03 Aug 2011 00:00:00
      Automated_description: Enables histone H3K27me2/H3K27me3 demethylase activity. Involved in transdifferentiation. Located in nucleus. Expressed in PDA and Y cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F18E9.5a
      F18E9.5b
    Corresponding_transcript: F18E9.5a.1
      F18E9.5a.2
      F18E9.5a.3
      F18E9.5b.1
    Associated_feature: WBsf655200
      WBsf663046
      WBsf716866
      WBsf716867
      WBsf717349
      WBsf1006198
      WBsf1006199
      WBsf1023440
      WBsf236063
      WBsf236064
  Experimental_info: RNAi_result: WBRNAi00103685 Inferred_automatically: RNAi_primary
      WBRNAi00066130 Inferred_automatically: RNAi_primary
      WBRNAi00044959 Inferred_automatically: RNAi_primary
      WBRNAi00089510 Inferred_automatically: RNAi_primary
      WBRNAi00091497 Inferred_automatically: RNAi_primary
      WBRNAi00001913 Inferred_automatically: RNAi_primary
      WBRNAi00013518 Inferred_automatically: RNAi_primary
      WBRNAi00089509 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11956
      Expr1012855
      Expr1037547
      Expr1148928
      Expr2012888
      Expr2031122
    Drives_construct: WBCnstr00019767
      WBCnstr00020760
      WBCnstr00020762
      WBCnstr00037997
    Construct_product: WBCnstr00019767
      WBCnstr00020760
      WBCnstr00020762
      WBCnstr00037997
    Regulate_expr_cluster: WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
    Microarray_results (26)
    Expression_cluster: WBPaper00032976:non_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059987:Wounding_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_downregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065158:AFD_enriched
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:1_0
      WBPaper00065841:35_1
      WBPaper00065841:117_0
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_4
      cgc4489_group_20
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_12
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045673:colistin_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(143_min)
      [cgc5976]:class_2
      [cgc6390]:Cluster_A
    Interaction (21)
  Map_info: Map: X Position: 0.120563 Error: 0.008795
    Positive: Positive_clone: F18E9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5117
        5495
        5569
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene