WormBase Tree Display for Gene: WBGene00017571

WBGene00017571 SMap: S_parent: Sequence: F18E9
  Identity: Version: 3
    Name: CGC_name: jmjd-3.1 Person_evidence: WBPerson1422
      Sequence_name: F18E9.5
      Molecular_name: F18E9.5a
        F18E9.5a.1
        CE30957
        F18E9.5b
        CE30958
        F18E9.5a.2
        F18E9.5a.3
        F18E9.5b.1
      Other_name: tag-279
        CELE_F18E9.5 Accession_evidence: NDB BX284606
      Public_name: jmjd-3.1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 30 Sep 2011 16:40:15 WBPerson2970 Name_change: CGC_name: jmjd-3.1
        3 08 Aug 2016 09:53:25 WBPerson2970 Name_change: Other_name: tag-279
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: jmjd
    Allele (94)
    Strain: WBStrain00036167
      WBStrain00036185
      WBStrain00040876
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (34)
    Paralog: WBGene00007813 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00009089 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00017046 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: jmjd-3.1 encodes, by alternative splicing, two isoforms of a histone H3 trimethyllysine-27 (H3K27me3) demethylase that is required for normal gonad migration and organization; JMJD-3.1 demethylates H3K27me3 in vitro; JMJD-3.1 contains an N-terminal TonB domain and a C-terminal JmjC domain, and is homologous to human JMJD3, UTX (OMIM:300128), and UTY (OMIM:400009); null jmjd-3.1(gk384) and jmjd-3.1(gk387) mutants have aberrant gonad migration and disordered diakinesis-phase oocytes, phenotypes enhanced at 25 deg. C.; JMJD-3.1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes. Paper_evidence: WBPaper00030964
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 03 Aug 2011 00:00:00
      Automated_description: Enables histone H3K27me2/H3K27me3 demethylase activity. Involved in transdifferentiation. Located in nucleus. Expressed in PDA and Y cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F18E9.5a
      F18E9.5b
    Corresponding_transcript: F18E9.5a.1
      F18E9.5a.2
      F18E9.5a.3
      F18E9.5b.1
    Associated_feature: WBsf655200
      WBsf663046
      WBsf716866
      WBsf716867
      WBsf717349
      WBsf1006198
      WBsf1006199
      WBsf1023440
      WBsf236063
      WBsf236064
  Experimental_info: RNAi_result: WBRNAi00103685 Inferred_automatically: RNAi_primary
      WBRNAi00066130 Inferred_automatically: RNAi_primary
      WBRNAi00044959 Inferred_automatically: RNAi_primary
      WBRNAi00089510 Inferred_automatically: RNAi_primary
      WBRNAi00091497 Inferred_automatically: RNAi_primary
      WBRNAi00001913 Inferred_automatically: RNAi_primary
      WBRNAi00013518 Inferred_automatically: RNAi_primary
      WBRNAi00089509 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11956
      Expr1012855
      Expr1037547
      Expr1148928
      Expr2012888
      Expr2031122
    Drives_construct: WBCnstr00019767
      WBCnstr00020760
      WBCnstr00020762
      WBCnstr00037997
    Construct_product: WBCnstr00019767
      WBCnstr00020760
      WBCnstr00020762
      WBCnstr00037997
    Regulate_expr_cluster: WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
    Microarray_results (26)
    Expression_cluster: WBPaper00032976:non_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059987:Wounding_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_downregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065158:AFD_enriched
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:1_0
      WBPaper00065841:35_1
      WBPaper00065841:117_0
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_4
      cgc4489_group_20
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_12
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045673:colistin_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(143_min)
      [cgc5976]:class_2
      [cgc6390]:Cluster_A
    Interaction (21)
  Map_info: Map: X Position: 0.120563 Error: 0.008795
    Positive: Positive_clone: F18E9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5117
        5495
        5569
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene