WormBase Tree Display for Gene: WBGene00017166

WBGene00017166 SMap: S_parent: Sequence: F01F1
  Identity: Version: 2
    Name: CGC_name: aldo-2 Person_evidence: WBPerson261
      Sequence_name: F01F1.12
      Molecular_name: F01F1.12
        F01F1.12.1
        CE01225
        F01F1.12.2
      Other_name: CELE_F01F1.12 Accession_evidence: NDB BX284603
      Public_name: aldo-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 Aug 2009 11:56:38 WBPerson9133 Name_change: CGC_name: aldo-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aldo
    Allele (29)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (47)
    Paralog: WBGene00011474 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: aldo-2 encodes a fructose-bisphosphate aldolase homologous to human ALDOB, which when mutated leads to fructosemia, hereditary fructose intolerance (OMIM:229600). Paper_evidence: WBPaper00004637
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 09 Sep 2009 00:00:00
      Automated_description: Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to be located in cytosol. Predicted to be part of heterochromatin. Expressed in several structures, including hyp7 syncytium. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Is an ortholog of human ALDOC (aldolase, fructose-bisphosphate C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:438 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:418)
  Molecular_info: Corresponding_CDS: F01F1.12
    Corresponding_CDS_history: F01F1.12b:wp275
    Corresponding_transcript: F01F1.12.1
      F01F1.12.2
    Other_sequence (568)
    Associated_feature: WBsf651081
      WBsf666461
      WBsf666462
      WBsf666934
      WBsf666935
      WBsf981488
      WBsf226734
      WBsf226735
  Experimental_info: RNAi_result: WBRNAi00006856 Inferred_automatically: RNAi_primary
      WBRNAi00113973 Inferred_automatically: RNAi_primary
      WBRNAi00024995 Inferred_automatically: RNAi_primary
      WBRNAi00043743 Inferred_automatically: RNAi_primary
      WBRNAi00008595 Inferred_automatically: RNAi_primary
      WBRNAi00043744 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr125
      Expr4048
      Expr1018341
      Expr1037380
      Expr1147728
      Expr2009286
      Expr2027523
    Drives_construct: WBCnstr00027516
    Construct_product: WBCnstr00027516
    Microarray_results (33)
    Expression_cluster: WBPaper00024245:gst-5-binding_control
      WBPaper00024704:Soluble_protein
      WBPaper00026640:Development_Group_I
      WBPaper00027022:tax-6(jh107)_downregulated
      WBPaper00028451:Oogenic_protein
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00036662:oxidative_modification
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:hypodermis_CoreEnriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00045971:tunicamycin_upregulated_RtcB(null)
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00046741:Garlic-Extract_upregulated_protein
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050199:hsf-1(ok600)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_nucleus_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
      WBPaper00060084:DVE-1_interacting_protein_control
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061221:H4K8ac_interacting
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:F45H10.2-R53.4_21676
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:CAN_enriched
      WBPaper00061651:CEPsh_enriched
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:Gonadal_sheath_cell_enriched
      WBPaper00061651:Intestine_enriched
      WBPaper00061651:PHso_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00062123:DEPS-1_interacting
      WBPaper00062123:GLH-1_interacting
      WBPaper00062143:PQN-59_interacting
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00063976:micu-1(bon20)_downregulated
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064315:mes-4(bn73)_downregulated_PGCs
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064789:Day9_vs_Day1_downregulated_neuron
      WBPaper00064789:Day12_vs_Day1_downregulated_neuron
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      cgc4386_cluster_1_2
      cgc4489_group_11
      WBPaper00025032:cluster_29
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026952:class_F
      WBPaper00026980:intestine_enriched
      WBPaper00027758:Group_I
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032948:StarveUp2
      WBPaper00035905:FBF-1_Associated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_22
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (67)
  Map_info: Map: III Position: -1.43798 Error: 5.9e-05
    Positive: Positive_clone: F01F1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027145
    WBPaper00028498
    WBPaper00031648
    WBPaper00038491
    WBPaper00049828
    WBPaper00055090
    WBPaper00056909
    WBPaper00061616
    WBPaper00063976
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene