WormBase Tree Display for Gene: WBGene00013878

WBGene00013878 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: atfs-1 Person_evidence: WBPerson9073
      Sequence_name: ZC376.7
      Molecular_name (15)
      Other_name: CELE_ZC376.7 Accession_evidence: NDB BX284605
      Public_name: atfs-1
    DB_info: Database: AceView gene 5O677
        WormQTL gene WBGene00013878
        WormFlux gene WBGene00013878
        NDB locus_tag CELE_ZC376.7
        Panther gene CAEEL|WormBase=WBGene00013878|UniProtKB=Q23272
          family PTHR13044
        NCBI gene 179922
        RefSeq protein NM_001269642.3
            NM_182360.9
            NM_074114.7
            NM_001029131.6
        SwissProt UniProtAcc Q23272
        TREEFAM TREEFAM_ID TF315772
        UniProt_GCRP UniProtAcc Q23272
    Species: Caenorhabditis elegans
    History: Version_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atfs
    Allele: WBVar02159240
      WBVar00015345
      WBVar01065920
      WBVar01065921
      WBVar01065922
      WBVar01065923
      WBVar01065924
      WBVar01065925
      WBVar01065926
      WBVar01065927
      WBVar01065928
      WBVar01065929
      WBVar01065930
      WBVar01065931
      WBVar01065932
      WBVar01065933
      WBVar01975415
      WBVar01065934
      WBVar01975416
      WBVar01065935
      WBVar01065936
      WBVar00598965
      WBVar01065937
      WBVar01065938
      WBVar01065939
      WBVar01065940
      WBVar01065941
      WBVar01065942
      WBVar01065943
      WBVar01744352
      WBVar01065944
      WBVar01744353
      WBVar01065945
      WBVar01744354
      WBVar01065946
      WBVar01744355
      WBVar01065947
      WBVar01065948
      WBVar01744356
      WBVar01065949
      WBVar01744357
      WBVar01065950
      WBVar01065951
      WBVar01065952
      WBVar01065953
      WBVar01065954
      WBVar01065955
      WBVar01065956
      WBVar01065957
      WBVar01065958
      WBVar01871521
      WBVar01065959
      WBVar01842774
      WBVar01871522
      WBVar01065960
      WBVar01065961
      WBVar01065962
      WBVar01590438
      WBVar01631092
      WBVar00601112
      WBVar01398442
      WBVar01678108
      WBVar02147414
      WBVar02147415
      WBVar02147416
      WBVar02147417
      WBVar02147418
      WBVar02147419
      WBVar02147420
      WBVar02147421
      WBVar02147422
      WBVar02147423
      WBVar01499621
      WBVar00476422
      WBVar00476423
      WBVar00476424
      WBVar00476425
      WBVar00476426
      WBVar00317350
      WBVar00476427
      WBVar00476428
      WBVar00296705
      WBVar00315837
      WBVar02024593
      WBVar02024594
      WBVar02024595
      WBVar00590857
      WBVar01500212
      WBVar01474240
      WBVar01500213
      WBVar01474241
      WBVar01484941
      WBVar01474242
      WBVar01474243
      WBVar01484942
      WBVar01484943
      WBVar01484944
      WBVar01499299
      WBVar01499316
      WBVar00015335
      WBVar02054862
      WBVar00015340
    Strain: WBStrain00031161
      WBStrain00031162
      WBStrain00031163
      WBStrain00031164
      WBStrain00037720
      WBStrain00052571
      WBStrain00052572
      WBStrain00052468
    RNASeq_FPKM (74)
    GO_annotation (68)
    Ortholog (23)
    Paralog: WBGene00000221 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007932 Caenorhabditis elegans From_analysis: Panther
      WBGene00012330 Caenorhabditis elegans From_analysis: Panther
      WBGene00077761 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus. Paper_evidence: WBPaper00035985
            WBPaper00041370
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Oct 2012 00:00:00
      Automated_description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:786)
  Molecular_info: Corresponding_CDS: ZC376.7a
      ZC376.7b
      ZC376.7c
      ZC376.7d
    Corresponding_CDS_history: ZC376.7:wp87
    Corresponding_transcript: ZC376.7a.1
      ZC376.7a.2
      ZC376.7b.1
      ZC376.7b.2
      ZC376.7c.1
      ZC376.7c.2
      ZC376.7d.1
    Other_sequence: CJC10202_1
      CR05510
      CJC00946_1
      CR05812
      MH00118
      Hbac_isotig01486
      CRC00297_1
      CBC02450_1
    Associated_feature (16)
    Gene_product_binds: WBsf980914
    Transcription_factor: WBTranscriptionFactor000444
  Experimental_info: RNAi_result (55)
    Expr_pattern: Expr8935
      Expr9728
      Expr9743
      Expr1015095
      Expr1036209
      Expr1162304
      Expr2009484
      Expr2027721
    Drives_construct: WBCnstr00013629
      WBCnstr00014248
      WBCnstr00014263
      WBCnstr00029481
    Construct_product: WBCnstr00013629
      WBCnstr00021929
      WBCnstr00029481
      WBCnstr00038813
    Regulate_expr_cluster (12)
    Antibody: WBAntibody00002652
    Microarray_results (32)
    Expression_cluster (116)
    Interaction (975)
    WBProcess: WBbiopr:00000077
      WBbiopr:00000079
  Map_info: Map: V Position: 6.19651 Error: 0.002029
    Positive: Positive_clone: ZC376 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (127)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene