WormBase Tree Display for Gene: WBGene00013878
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WBGene00013878 | SMap | S_parent | Sequence | CHROMOSOME_V | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | atfs-1 | Person_evidence | WBPerson9073 | |||
Sequence_name | ZC376.7 | ||||||
Molecular_name (15) | |||||||
Other_name | CELE_ZC376.7 | Accession_evidence | NDB | BX284605 | |||
Public_name | atfs-1 | ||||||
DB_info | Database | AceView | gene | 5O677 | |||
WormQTL | gene | WBGene00013878 | |||||
WormFlux | gene | WBGene00013878 | |||||
NDB | locus_tag | CELE_ZC376.7 | |||||
Panther | gene | CAEEL|WormBase=WBGene00013878|UniProtKB=Q23272 | |||||
family | PTHR13044 | ||||||
NCBI | gene | 179922 | |||||
RefSeq | protein | NM_001269642.3 | |||||
NM_182360.9 | |||||||
NM_074114.7 | |||||||
NM_001029131.6 | |||||||
SwissProt | UniProtAcc | Q23272 | |||||
TREEFAM | TREEFAM_ID | TF315772 | |||||
UniProt_GCRP | UniProtAcc | Q23272 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | atfs | ||||||
Allele (102) | |||||||
Strain | WBStrain00031161 | ||||||
WBStrain00031162 | |||||||
WBStrain00031163 | |||||||
WBStrain00031164 | |||||||
WBStrain00037720 | |||||||
WBStrain00052571 | |||||||
WBStrain00052572 | |||||||
WBStrain00052468 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (68) | |||||||
Ortholog (23) | |||||||
Paralog | WBGene00000221 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00007932 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00012330 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00077761 | Caenorhabditis elegans | From_analysis | Panther | ||||
Structured_description | Concise_description | atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus. | Paper_evidence | WBPaper00035985 | |||
WBPaper00041370 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 23 Oct 2012 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:786) | ||
Molecular_info | Corresponding_CDS | ZC376.7a | |||||
ZC376.7b | |||||||
ZC376.7c | |||||||
ZC376.7d | |||||||
Corresponding_CDS_history | ZC376.7:wp87 | ||||||
Corresponding_transcript | ZC376.7a.1 | ||||||
ZC376.7a.2 | |||||||
ZC376.7b.1 | |||||||
ZC376.7b.2 | |||||||
ZC376.7c.1 | |||||||
ZC376.7c.2 | |||||||
ZC376.7d.1 | |||||||
Other_sequence | CJC10202_1 | ||||||
CR05510 | |||||||
CJC00946_1 | |||||||
CR05812 | |||||||
MH00118 | |||||||
Hbac_isotig01486 | |||||||
CRC00297_1 | |||||||
CBC02450_1 | |||||||
Associated_feature (16) | |||||||
Gene_product_binds | WBsf980914 | ||||||
Transcription_factor | WBTranscriptionFactor000444 | ||||||
Experimental_info | RNAi_result (55) | ||||||
Expr_pattern | Expr8935 | ||||||
Expr9728 | |||||||
Expr9743 | |||||||
Expr1015095 | |||||||
Expr1036209 | |||||||
Expr1162304 | |||||||
Expr2009484 | |||||||
Expr2027721 | |||||||
Drives_construct | WBCnstr00013629 | ||||||
WBCnstr00014248 | |||||||
WBCnstr00014263 | |||||||
WBCnstr00029481 | |||||||
Construct_product | WBCnstr00013629 | ||||||
WBCnstr00021929 | |||||||
WBCnstr00029481 | |||||||
WBCnstr00038813 | |||||||
Regulate_expr_cluster (12) | |||||||
Antibody | WBAntibody00002652 | ||||||
Microarray_results (32) | |||||||
Expression_cluster (116) | |||||||
Interaction (975) | |||||||
WBProcess | WBbiopr:00000077 | ||||||
WBbiopr:00000079 | |||||||
Map_info | Map | V | Position | 6.19651 | Error | 0.002029 | |
Positive | Positive_clone | ZC376 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (127) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |