WormBase Tree Display for Gene: WBGene00013878
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| WBGene00013878 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | atfs-1 | Person_evidence | WBPerson9073 | |||||
| Sequence_name | ZC376.7 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_ZC376.7 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | atfs-1 | ||||||||
| DB_info | Database | AceView | gene | 5O677 | |||||
| WormQTL | gene | WBGene00013878 | |||||||
| WormFlux | gene | WBGene00013878 | |||||||
| NDB | locus_tag | CELE_ZC376.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00013878|UniProtKB=Q23272 | |||||||
| family | PTHR13044 | ||||||||
| NCBI | gene | 179922 | |||||||
| RefSeq | protein | NM_001269642.3 | |||||||
| NM_182360.9 | |||||||||
| NM_074114.7 | |||||||||
| NM_001029131.6 | |||||||||
| SwissProt | UniProtAcc | Q23272 | |||||||
| TREEFAM | TREEFAM_ID | TF315772 | |||||||
| UniProt_GCRP | UniProtAcc | Q23272 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 24 May 2011 10:23:31 | WBPerson2970 | Name_change | CGC_name | atfs-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | atfs | ||||||||
| Allele (102) | |||||||||
| Strain | WBStrain00031161 | ||||||||
| WBStrain00031162 | |||||||||
| WBStrain00031163 | |||||||||
| WBStrain00031164 | |||||||||
| WBStrain00037720 | |||||||||
| WBStrain00052571 | |||||||||
| WBStrain00052572 | |||||||||
| WBStrain00052468 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (68) | |||||||||
| Ortholog (23) | |||||||||
| Paralog | WBGene00000221 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00007932 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00012330 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00077761 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus. | Paper_evidence | WBPaper00035985 | |||||
| WBPaper00041370 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Oct 2012 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:786) | ||||
| Molecular_info | Corresponding_CDS | ZC376.7a | |||||||
| ZC376.7b | |||||||||
| ZC376.7c | |||||||||
| ZC376.7d | |||||||||
| Corresponding_CDS_history | ZC376.7:wp87 | ||||||||
| Corresponding_transcript | ZC376.7a.1 | ||||||||
| ZC376.7a.2 | |||||||||
| ZC376.7b.1 | |||||||||
| ZC376.7b.2 | |||||||||
| ZC376.7c.1 | |||||||||
| ZC376.7c.2 | |||||||||
| ZC376.7d.1 | |||||||||
| Other_sequence | CJC10202_1 | ||||||||
| CR05510 | |||||||||
| CJC00946_1 | |||||||||
| CR05812 | |||||||||
| MH00118 | |||||||||
| Hbac_isotig01486 | |||||||||
| CRC00297_1 | |||||||||
| CBC02450_1 | |||||||||
| Associated_feature (16) | |||||||||
| Gene_product_binds | WBsf980914 | ||||||||
| Transcription_factor | WBTranscriptionFactor000444 | ||||||||
| Experimental_info | RNAi_result (55) | ||||||||
| Expr_pattern | Expr8935 | ||||||||
| Expr9728 | |||||||||
| Expr9743 | |||||||||
| Expr1015095 | |||||||||
| Expr1036209 | |||||||||
| Expr1162304 | |||||||||
| Expr2009484 | |||||||||
| Expr2027721 | |||||||||
| Drives_construct | WBCnstr00013629 | ||||||||
| WBCnstr00014248 | |||||||||
| WBCnstr00014263 | |||||||||
| WBCnstr00029481 | |||||||||
| Construct_product | WBCnstr00013629 | ||||||||
| WBCnstr00021929 | |||||||||
| WBCnstr00029481 | |||||||||
| WBCnstr00038813 | |||||||||
| Regulate_expr_cluster (12) | |||||||||
| Antibody | WBAntibody00002652 | ||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (975) | |||||||||
| WBProcess | WBbiopr:00000077 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | V | Position | 6.19651 | Error | 0.002029 | |||
| Positive | Positive_clone | ZC376 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (127) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
