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WormBase Tree Display for Gene: WBGene00013643

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Name Class

WBGene00013643SMapS_parentSequenceY105C5A
IdentityVersion1
NameSequence_nameY105C5A.24
Molecular_nameY105C5A.24
Y105C5A.24.1
CE36218
Other_nameCELE_Y105C5A.24Accession_evidenceNDBBX284604
Public_nameY105C5A.24
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:55WBPerson1971EventImportedInitial conversion from CDS class of WS125
StatusLive
Gene_infoBiotypeSO:0001217
Allele (84)
RNASeq_FPKM (74)
GO_annotation (32)
Ortholog (25)
Paralog (13)
Structured_descriptionAutomated_descriptionPredicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including autophagy; axon extension; and positive regulation of autophagy. Predicted to be located in autophagosome; cytosol; and phagophore assembly site membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); frontometaphyseal dysplasia 2; and intrinsic cardiomyopathy (multiple). Is an ortholog of human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).Paper_evidenceWBPaper00065943
Curator_confirmed (2)
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111785Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
DOID:11520Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
DOID:11984Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
DOID:0111787Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
DOID:12930Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
DOID:3393Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6859)
Molecular_infoCorresponding_CDSY105C5A.24
Corresponding_CDS_historyY105C5A.24:wp114
Corresponding_transcriptY105C5A.24.1
Other_sequenceOden_isotig05394
ACC13097_1
Oden_isotig05392
Oden_isotig05395
EX563505.1
Oden_isotig05396
Oden_isotig05393
Oden_isotig05391
Associated_feature (11)
Experimental_infoRNAi_resultWBRNAi00112980Inferred_automaticallyRNAi_primary
WBRNAi00019848Inferred_automaticallyRNAi_primary
WBRNAi00055181Inferred_automaticallyRNAi_primary
WBRNAi00113210Inferred_automaticallyRNAi_primary
WBRNAi00036464Inferred_automaticallyRNAi_primary
Expr_patternExpr1022564
Expr1036096
Expr1158714
Expr2006945
Expr2025171
Drives_constructWBCnstr00029576
Construct_productWBCnstr00029576
Microarray_results (18)
Expression_clusterWBPaper00027022:tax-6(jh107)_upregulated
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00037950:intestine_CoreEnriched
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_larva_enriched
WBPaper00037950:intestine_larva_SelectivelyEnriched
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00045314:S.aureus-induced_N2
WBPaper00045934:wrn-1(gk99)_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048988:neuron_expressed
WBPaper00049334:CE_intestine_enriched
WBPaper00049495:starvation-refeeding_regulated
WBPaper00050121:mir-60(n4947)_upregulated
WBPaper00050332:daf-16(RNAi)_downregulated
WBPaper00050332:skn-1(RNAi)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:intestine_enriched
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053664:ins-11(tm1053)_downregulated
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056161:male_enriched_siRNA
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058711:wdr-5(ok1417)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059253:stearic-acid_upregulated
WBPaper00059253:sucrose_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_depleted
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
WBPaper00061527:nhr-18-C34D1.4_6256
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064632:daf-2(e1370)_upregulated_intestine
WBPaper00064716:paraquat_downregulated
WBPaper00065258:anchor-cell_depleted
WBPaper00065272:dhgd-1(tm6671)_upregulated
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:Cisplatin_upregulated_diploid
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4386_cluster_1_5
cgc4489_group_22
WBPaper00026980:intestine_enriched
WBPaper00032165:A_to_C_transit_decreased
WBPaper00032165:differentially_expressed_with_age_medoid_4
WBPaper00032948:StarveUp2
WBPaper00035227:heat_shock_regulated
WBPaper00036286:Pattern_I
WBPaper00037695:LD_DD_6-day
WBPaper00038060:SUMO-1_downregulated
WBPaper00038172:aak-2overexpression_down_regulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_N2
[cgc6390]:Cluster_A
Interaction (27)
Map_infoPositivePositive_cloneY105C5AInferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionIV14.4082
ReferenceWBPaper00024295
WBPaper00038491
WBPaper00055090
WBPaper00065331
MethodGene