WormBase Tree Display for Gene: WBGene00013111
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| WBGene00013111 | SMap | S_parent | Sequence | Y51H4A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sta-1 | Paper_evidence | WBPaper00027021 | |||||
| Person_evidence | WBPerson3046 | ||||||||
| Sequence_name | Y51H4A.17 | ||||||||
| Molecular_name | Y51H4A.17a | ||||||||
| Y51H4A.17a.1 | |||||||||
| CE35668 | |||||||||
| Y51H4A.17b | |||||||||
| CE41061 | |||||||||
| Y51H4A.17c | |||||||||
| CE22342 | |||||||||
| Y51H4A.17b.1 | |||||||||
| Y51H4A.17c.1 | |||||||||
| Other_name | CELE_Y51H4A.17 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | sta-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00013111 | |||||
| SignaLink | protein | WBGene00013111 | |||||||
| WormFlux | gene | WBGene00013111 | |||||||
| NDB | locus_tag | CELE_Y51H4A.17 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00013111|UniProtKB=Q9NAD6 | |||||||
| family | PTHR11801 | ||||||||
| NCBI | gene | 178465 | |||||||
| RefSeq | protein | NM_001129342.4 | |||||||
| NM_070573.6 | |||||||||
| NM_001129343.3 | |||||||||
| SwissProt | UniProtAcc | Q9NAD6 | |||||||
| UniProt_GCRP | UniProtAcc | Q9NAD6 | |||||||
| OMIM | gene | 102582 | |||||||
| 600555 | |||||||||
| 600558 | |||||||||
| 604260 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 17 Mar 2006 11:45:43 | WBPerson2970 | Name_change | CGC_name | sta-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sta | ||||||||
| Allele (126) | |||||||||
| Strain | WBStrain00001751 | ||||||||
| WBStrain00031509 | |||||||||
| WBStrain00055554 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (63) | |||||||||
| Paralog | WBGene00010251 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00013112 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||||
| WBGene00013113 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||||
| WBGene00013114 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||||
| Structured_description | Concise_description | sta-1 encodes a protein that is a member of the STAT family of transcription factors; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling. | Paper_evidence | WBPaper00027021 | |||||
| WBPaper00028315 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Dec 2009 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (70) | ||||||||
| Molecular_info | Corresponding_CDS | Y51H4A.17a | |||||||
| Y51H4A.17b | |||||||||
| Y51H4A.17c | |||||||||
| Corresponding_CDS_history | Y51H4A.17:wp109 | ||||||||
| Corresponding_transcript | Y51H4A.17a.1 | ||||||||
| Y51H4A.17b.1 | |||||||||
| Y51H4A.17c.1 | |||||||||
| Associated_feature | WBsf978772 | ||||||||
| WBsf998902 | |||||||||
| WBsf998903 | |||||||||
| WBsf998904 | |||||||||
| WBsf998905 | |||||||||
| WBsf1018895 | |||||||||
| WBsf1018896 | |||||||||
| WBsf229606 | |||||||||
| WBsf229607 | |||||||||
| Transcription_factor | WBTranscriptionFactor000234 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002566 | ||||||||
| WBCnstr00012870 | |||||||||
| WBCnstr00019052 | |||||||||
| Construct_product | WBCnstr00040908 | ||||||||
| Regulate_expr_cluster | WBPaper00053020:sta-1(ok587)_downregulated | ||||||||
| WBPaper00053020:sta-1(ok587)_upregulated | |||||||||
| Antibody | WBAntibody00001051 | ||||||||
| WBAntibody00001672 | |||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (224) | |||||||||
| Map_info | Map | IV | Position | 15.1793 | |||||
| Positive | Positive_clone | Y51H4A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
