WormBase Tree Display for Gene: WBGene00013111

WBGene00013111 SMap: S_parent: Sequence: Y51H4A
  Identity: Version: 2
    Name: CGC_name: sta-1 Paper_evidence: WBPaper00027021
          Person_evidence: WBPerson3046
      Sequence_name: Y51H4A.17
      Molecular_name: Y51H4A.17a
        Y51H4A.17a.1
        CE35668
        Y51H4A.17b
        CE41061
        Y51H4A.17c
        CE22342
        Y51H4A.17b.1
        Y51H4A.17c.1
      Other_name: CELE_Y51H4A.17 Accession_evidence: NDB BX284604
      Public_name: sta-1
    DB_info: Database: WormQTL gene WBGene00013111
        SignaLink protein WBGene00013111
        WormFlux gene WBGene00013111
        NDB locus_tag CELE_Y51H4A.17
        Panther gene CAEEL|WormBase=WBGene00013111|UniProtKB=Q9NAD6
          family PTHR11801
        NCBI gene 178465
        RefSeq protein NM_001129342.4
            NM_070573.6
            NM_001129343.3
        SwissProt UniProtAcc Q9NAD6
        UniProt_GCRP UniProtAcc Q9NAD6
        OMIM gene 102582
            600555
            600558
            604260
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 17 Mar 2006 11:45:43 WBPerson2970 Name_change: CGC_name: sta-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sta
    Allele (126)
    Strain: WBStrain00001751
      WBStrain00031509
      WBStrain00055554
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (63)
    Paralog: WBGene00010251 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013112 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00013113 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00013114 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
    Structured_description: Concise_description: sta-1 encodes a protein that is a member of the STAT family of transcription factors; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling. Paper_evidence: WBPaper00027021
            WBPaper00028315
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Dec 2009 00:00:00
      Automated_description: Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (70)
  Molecular_info: Corresponding_CDS: Y51H4A.17a
      Y51H4A.17b
      Y51H4A.17c
    Corresponding_CDS_history: Y51H4A.17:wp109
    Corresponding_transcript: Y51H4A.17a.1
      Y51H4A.17b.1
      Y51H4A.17c.1
    Associated_feature: WBsf978772
      WBsf998902
      WBsf998903
      WBsf998904
      WBsf998905
      WBsf1018895
      WBsf1018896
      WBsf229606
      WBsf229607
    Transcription_factor: WBTranscriptionFactor000234
  Experimental_info: RNAi_result (18)
    Expr_pattern (12)
    Drives_construct: WBCnstr00002566
      WBCnstr00012870
      WBCnstr00019052
    Construct_product: WBCnstr00040908
    Regulate_expr_cluster: WBPaper00053020:sta-1(ok587)_downregulated
      WBPaper00053020:sta-1(ok587)_upregulated
    Antibody: WBAntibody00001051
      WBAntibody00001672
    Microarray_results (36)
    Expression_cluster (166)
    Interaction: WBInteraction000005482
      WBInteraction000009553
      WBInteraction000029499
      WBInteraction000029541
      WBInteraction000030155
      WBInteraction000030880
      WBInteraction000031325
      WBInteraction000031638
      WBInteraction000031643
      WBInteraction000032301
      WBInteraction000032376
      WBInteraction000032377
      WBInteraction000032378
      WBInteraction000032649
      WBInteraction000032736
      WBInteraction000032883
      WBInteraction000032943
      WBInteraction000037198
      WBInteraction000037199
      WBInteraction000037200
      WBInteraction000038042
      WBInteraction000040023
      WBInteraction000040024
      WBInteraction000040744
      WBInteraction000041240
      WBInteraction000041611
      WBInteraction000042931
      WBInteraction000042932
      WBInteraction000043170
      WBInteraction000043175
      WBInteraction000043176
      WBInteraction000043914
      WBInteraction000043953
      WBInteraction000043993
      WBInteraction000044411
      WBInteraction000045109
      WBInteraction000045479
      WBInteraction000045792
      WBInteraction000045793
      WBInteraction000045794
      WBInteraction000046411
      WBInteraction000048707
      WBInteraction000049948
      WBInteraction000049960
      WBInteraction000117953
      WBInteraction000117954
      WBInteraction000118567
      WBInteraction000119447
      WBInteraction000120124
      WBInteraction000120137
      WBInteraction000122872
      WBInteraction000123085
      WBInteraction000123168
      WBInteraction000123169
      WBInteraction000123170
      WBInteraction000123179
      WBInteraction000123188
      WBInteraction000123195
      WBInteraction000123196
      WBInteraction000123215
      WBInteraction000123216
      WBInteraction000123368
      WBInteraction000123369
      WBInteraction000123381
      WBInteraction000123382
      WBInteraction000123383
      WBInteraction000123391
      WBInteraction000123392
      WBInteraction000123393
      WBInteraction000123394
      WBInteraction000123395
      WBInteraction000123396
      WBInteraction000123397
      WBInteraction000123398
      WBInteraction000123399
      WBInteraction000123400
      WBInteraction000123401
      WBInteraction000123402
      WBInteraction000123403
      WBInteraction000123404
      WBInteraction000123405
      WBInteraction000123406
      WBInteraction000123411
      WBInteraction000123718
      WBInteraction000123719
      WBInteraction000123872
      WBInteraction000123914
      WBInteraction000123916
      WBInteraction000123917
      WBInteraction000123918
      WBInteraction000123919
      WBInteraction000123920
      WBInteraction000123921
      WBInteraction000123922
      WBInteraction000123923
      WBInteraction000123924
      WBInteraction000123928
      WBInteraction000123936
      WBInteraction000150800
      WBInteraction000150809
      WBInteraction000150811
      WBInteraction000150813
      WBInteraction000150814
      WBInteraction000151071
      WBInteraction000151075
      WBInteraction000151095
      WBInteraction000152378
      WBInteraction000152476
      WBInteraction000153048
      WBInteraction000157046
      WBInteraction000157049
      WBInteraction000157371
      WBInteraction000159276
      WBInteraction000159792
      WBInteraction000159824
      WBInteraction000160288
      WBInteraction000160922
      WBInteraction000161034
      WBInteraction000161649
      WBInteraction000161813
      WBInteraction000162278
      WBInteraction000162431
      WBInteraction000162589
      WBInteraction000162610
      WBInteraction000162910
      WBInteraction000162911
      WBInteraction000162940
      WBInteraction000162948
      WBInteraction000163182
      WBInteraction000164254
      WBInteraction000167098
      WBInteraction000167253
      WBInteraction000167654
      WBInteraction000167779
      WBInteraction000169419
      WBInteraction000169495
      WBInteraction000169989
      WBInteraction000169990
      WBInteraction000170043
      WBInteraction000173141
      WBInteraction000173144
      WBInteraction000173147
      WBInteraction000173242
      WBInteraction000173247
      WBInteraction000173253
      WBInteraction000173263
      WBInteraction000173274
      WBInteraction000173292
      WBInteraction000173298
      WBInteraction000173314
      WBInteraction000173326
      WBInteraction000173334
      WBInteraction000173342
      WBInteraction000173411
      WBInteraction000173487
      WBInteraction000173508
      WBInteraction000173684
      WBInteraction000173759
      WBInteraction000173802
      WBInteraction000174327
      WBInteraction000174328
      WBInteraction000174329
      WBInteraction000174330
      WBInteraction000174331
      WBInteraction000174332
      WBInteraction000264887
      WBInteraction000264925
      WBInteraction000264926
      WBInteraction000276270
      WBInteraction000384117
      WBInteraction000384169
      WBInteraction000388179
      WBInteraction000417003
      WBInteraction000502299
      WBInteraction000502300
      WBInteraction000513785
      WBInteraction000513787
      WBInteraction000513788
      WBInteraction000513789
      WBInteraction000513790
      WBInteraction000513793
      WBInteraction000513794
      WBInteraction000513795
      WBInteraction000513797
      WBInteraction000513799
      WBInteraction000513801
      WBInteraction000513803
      WBInteraction000513804
      WBInteraction000513805
      WBInteraction000513806
      WBInteraction000513807
      WBInteraction000513808
      WBInteraction000513809
      WBInteraction000513812
      WBInteraction000513813
      WBInteraction000513816
      WBInteraction000513819
      WBInteraction000513820
      WBInteraction000513822
      WBInteraction000513823
      WBInteraction000516282
      WBInteraction000516283
      WBInteraction000516284
      WBInteraction000516285
      WBInteraction000516286
      WBInteraction000516287
      WBInteraction000516288
      WBInteraction000516289
      WBInteraction000516290
      WBInteraction000516291
      WBInteraction000516292
      WBInteraction000516293
      WBInteraction000516294
      WBInteraction000516295
      WBInteraction000516296
      WBInteraction000516297
      WBInteraction000516298
      WBInteraction000516299
      WBInteraction000527236
      WBInteraction000560631
      WBInteraction000576352
      WBInteraction000578351
      WBInteraction000583629
      WBInteraction000584002
  Map_info: Map: IV Position: 15.1793
    Positive: Positive_clone: Y51H4A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene