WormBase Tree Display for Gene: WBGene00013111
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WBGene00013111 | SMap | S_parent | Sequence | Y51H4A | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | sta-1 | Paper_evidence | WBPaper00027021 | |||
Person_evidence | WBPerson3046 | ||||||
Sequence_name | Y51H4A.17 | ||||||
Molecular_name | Y51H4A.17a | ||||||
Y51H4A.17a.1 | |||||||
CE35668 | |||||||
Y51H4A.17b | |||||||
CE41061 | |||||||
Y51H4A.17c | |||||||
CE22342 | |||||||
Y51H4A.17b.1 | |||||||
Y51H4A.17c.1 | |||||||
Other_name | CELE_Y51H4A.17 | Accession_evidence | NDB | BX284604 | |||
Public_name | sta-1 | ||||||
DB_info | Database | WormQTL | gene | WBGene00013111 | |||
SignaLink | protein | WBGene00013111 | |||||
WormFlux | gene | WBGene00013111 | |||||
NDB | locus_tag | CELE_Y51H4A.17 | |||||
Panther | gene | CAEEL|WormBase=WBGene00013111|UniProtKB=Q9NAD6 | |||||
family | PTHR11801 | ||||||
NCBI | gene | 178465 | |||||
RefSeq | protein | NM_001129342.4 | |||||
NM_070573.6 | |||||||
NM_001129343.3 | |||||||
SwissProt | UniProtAcc | Q9NAD6 | |||||
UniProt_GCRP | UniProtAcc | Q9NAD6 | |||||
OMIM | gene | 102582 | |||||
600555 | |||||||
600558 | |||||||
604260 | |||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sta | ||||||
Allele (126) | |||||||
Strain | WBStrain00001751 | ||||||
WBStrain00031509 | |||||||
WBStrain00055554 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (26) | |||||||
Ortholog (63) | |||||||
Paralog | WBGene00010251 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00013112 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||
WBGene00013113 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||
WBGene00013114 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||
Structured_description | Concise_description | sta-1 encodes a protein that is a member of the STAT family of transcription factors; from N- to C-terminus, STA-1 contains conserved coiled-coil, DNA-binding, and SH2 domains, but apparently lacks a conserved amino-terminal oligomerization domain found in other STAT family members; sta-1 activity is required for repressing dauer formation at high temperatures and genetic analyses indicate that STA-1 acts redundantly with some members of the DAF-7/TGF-beta signaling pathway to repress dauer formation, particularly at low temperatures; tyrosine-phosphorylated STA-1 is able to bind a high affinity mammalian STAT binding sequence, and the STA-1 C-terminus can function as a transcriptional activation domain; sta-1 is widely expressed during most life stages, including the dauer stage, and is found in the pharynx, intestine, body wall muscles, and in neurons; STA-1 localizes to both the cytoplasm and the nucleus, with expression in the latter found particularly in some amphid neurons; in some neurons, STA-1 expression appears to be negatively regulated by DAF-7/TGF-beta signaling. | Paper_evidence | WBPaper00027021 | |||
WBPaper00028315 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 14 Dec 2009 00:00:00 | ||||||
Automated_description | Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (70) | ||||||
Molecular_info | Corresponding_CDS | Y51H4A.17a | |||||
Y51H4A.17b | |||||||
Y51H4A.17c | |||||||
Corresponding_CDS_history | Y51H4A.17:wp109 | ||||||
Corresponding_transcript | Y51H4A.17a.1 | ||||||
Y51H4A.17b.1 | |||||||
Y51H4A.17c.1 | |||||||
Associated_feature | WBsf978772 | ||||||
WBsf998902 | |||||||
WBsf998903 | |||||||
WBsf998904 | |||||||
WBsf998905 | |||||||
WBsf1018895 | |||||||
WBsf1018896 | |||||||
WBsf229606 | |||||||
WBsf229607 | |||||||
Transcription_factor | WBTranscriptionFactor000234 | ||||||
Experimental_info | RNAi_result (18) | ||||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00002566 | ||||||
WBCnstr00012870 | |||||||
WBCnstr00019052 | |||||||
Construct_product | WBCnstr00040908 | ||||||
Regulate_expr_cluster | WBPaper00053020:sta-1(ok587)_downregulated | ||||||
WBPaper00053020:sta-1(ok587)_upregulated | |||||||
Antibody | WBAntibody00001051 | ||||||
WBAntibody00001672 | |||||||
Microarray_results (36) | |||||||
Expression_cluster (166) | |||||||
Interaction (224) | |||||||
Map_info | Map | IV | Position | 15.1793 | |||
Positive | Positive_clone | Y51H4A | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (21) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |