WormBase Tree Display for Gene: WBGene00013073

WBGene00013073 SMap: S_parent: Sequence: Y51A2D
  Identity: Version: 2
    Name: CGC_name: hmit-1.1 Person_evidence: WBPerson353
      Sequence_name: Y51A2D.4
      Molecular_name: Y51A2D.4
        Y51A2D.4.1
        CE19201
      Other_name: CELE_Y51A2D.4 Accession_evidence: NDB BX284605
      Public_name: hmit-1.1
    DB_info: Database: AceView gene 5T3
        WormQTL gene WBGene00013073
        WormFlux gene WBGene00013073
        NDB locus_tag CELE_Y51A2D.4
        Panther gene CAEEL|WormBase=WBGene00013073|UniProtKB=Q9XXR3
          family PTHR48020
        NCBI gene 180205
        RefSeq protein NM_075222.5
        SwissProt UniProtAcc Q9XXR3
        TREEFAM TREEFAM_ID TF314916
        UniProt_GCRP UniProtAcc Q9XXR3
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 16 Feb 2007 14:39:36 WBPerson2970 Name_change: CGC_name: hmit-1.1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hmit
    Allele (254)
    Strain: WBStrain00032845
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (40)
    Paralog (25)
    Structured_description: Concise_description: hmit-1.1 encodes one of three C. elegans proton (H+)-dependent myo-inositol transporters; loss of hmit-1.1 activity via large-scale RNAi result in no obvious abnormalities but by homology, HMIT-1.1 is predicted to function as a plasma membrane protein required for the regulated uptake of myo-inositol and thus potentially for regulation of cell signaling and intracellular osmolarity. Curator_confirmed: WBPerson1843
          Date_last_updated: 25 Apr 2007 00:00:00
      Automated_description: Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in myo-inositol transport and transmembrane transport. Located in apical plasma membrane. Expressed in intestinal cell. Is an ortholog of human SLC2A13 (solute carrier family 2 member 13). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y51A2D.4
    Corresponding_transcript: Y51A2D.4.1
    Other_sequence (21)
    Associated_feature: WBsf647682
      WBsf1002922
      WBsf1002923
      WBsf1002924
  Experimental_info: RNAi_result: WBRNAi00057137 Inferred_automatically: RNAi_primary
      WBRNAi00097120 Inferred_automatically: RNAi_primary
      WBRNAi00020873 Inferred_automatically: RNAi_primary
      WBRNAi00037349 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9308
      Expr9311
      Expr1016622
      Expr1035802
      Expr1160584
      Expr2012526
      Expr2030765
    Drives_construct: WBCnstr00008839
      WBCnstr00008842
      WBCnstr00008844
      WBCnstr00013889
      WBCnstr00013892
    Construct_product: WBCnstr00008842
      WBCnstr00013892
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:up_in_rde-4
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036738:4uM_Heme_upregulated
      WBPaper00036738:500uM_Heme_upregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated
      WBPaper00042034:NO_upregulated_N2
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044246:pgrn-1_ced-3_ced-1_downregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044557:DietaryRestriction_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(gk119)_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046499:AMPK_regulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049098:heat-induced_hrde-1(tm1200)
      WBPaper00049098:hrde-1(tm1200)-induced_23C
      WBPaper00049484:elt-2(RNAi)_upregulated_L4
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:15deg-then-25deg(12hr)_upregulated_N2
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050109:rBmTX14_upregulated
      WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051137:Orsay-virus_downregulated_rde-1(ne219)
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051311:VGLN-1-interacting
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00053140:SustainedResponse_20nmAgCit
      WBPaper00053154:human-amyloid-beta_tau_regulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_upregulated_OP50
      WBPaper00054192:cold-shock_downregulated
      WBPaper00054410:set-9(rw5)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056169:rrf-3(pk1426)_downregulated_adult
      WBPaper00056218:daf-16(mu86)_downregulated_Day7
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:numr-1(RNAi)_upregulated
      WBPaper00057196:raga-1(ok386)_upregulated)
      WBPaper00057265:metaformin_upregulated_OP50-MR
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059537:ngn-1(ok2200)_downregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_12h_regulated
      WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:M.braciatum_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061340:AVH
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061405:S.aureus_upregulated_starvation
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
      WBPaper00061699:daf-18(ok480)_upregulated
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062606:rotenone_downregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064375:sid-1(pk3321)_regulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064502:spe-44(fx110)_downregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064602:egl-9(sa307)_downregulated
      WBPaper00064661:lpd-3(ok2138)_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065581:hpk-1(pk1393)_downregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065835:mtH2S-AP39-L1-treatment_upregulated_Day11
      WBPaper00065841:3_5
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      cgc4386_cluster_1_1
      cgc4489_group_7
      WBPaper00028789:PA14_vs_gacA_downregulated_4hr
      WBPaper00028789:PA14_vs_gacA_downregulated_8hr
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00031703:heme_responsive_5
      WBPaper00032948:FedUp
      WBPaper00033101:spr-5_regulated
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00037147:heatshock_downregulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00038462:aging_downregulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00039866:SAM_daf-19_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041207:CE_dauer_down
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00042258:HT115_downregulated_YoungAdult
      WBPaper00044013:nasp-1_upregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047021:MWCNT_upregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00050650:mBmkTX_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00053688:E.faecalis_upregulated
      [cgc6390]:Cluster_C
    Interaction (41)
  Map_info: Map: V Position: 16.8086 Error: 0.020702
    Positive: Positive_clone: Y51A2D Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00036738
    WBPaper00038491
    WBPaper00038529
    WBPaper00055090
    WBPaper00060410
    WBPaper00064375
    WBPaper00064435
    WBPaper00065156
    WBPaper00065341
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene