WormBase Tree Display for Gene: WBGene00011672

WBGene00011672 SMap: S_parent: Sequence: T10B9
  Identity: Version: 2
    Name: CGC_name: cyp-13A5
      Sequence_name: T10B9.2
      Molecular_name: T10B9.2
        T10B9.2.1
        CE01656
      Other_name: CELE_T10B9.2 Accession_evidence: NDB BX284602
      Public_name: cyp-13A5
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-13A5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (36)
    RNASeq_FPKM (74)
    GO_annotation: 00079947
      00079948
      00079949
      00118899
      00118900
      00118901
      00118902
    Ortholog: WBGene00024322 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00024327 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            WormBase-Compara
      WBGene00024351 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00024561 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00067223 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00162595 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00131554 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00128819 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00191122 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00213308 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00092752 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00104757 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00119176 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00095336 Pristionchus pacificus From_analysis: Inparanoid_8
      CSP21.g13632 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g8455 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7740 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP32.g2810 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP40.g22857 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g22859 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g2333 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00173.g6203 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_II.g4009 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g8940 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01510.g21369 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_01510.g21370 Caenorhabditis sinica From_analysis: WormBase-Compara
      GCK72_004786 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g20388 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g22855 Panagrellus redivivus From_analysis: WormBase-Compara
      chrII_pilon.g5595 Caenorhabditis elegans From_analysis: WormBase-Compara
      FB:FBgn0033304 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      FB:FBgn0033978 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      FB:FBgn0033979 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      FB:FBgn0033980 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      FB:FBgn0033982 Drosophila melanogaster From_analysis: OMA
            OrthoFinder
            SonicParanoid
      FB:FBgn0038194 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      FB:FBgn0015714 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      FB:FBgn0031726 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            SonicParanoid
      ZFIN:ZDB-GENE-041114-102 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-050604-1 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-060929-96 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-030131-8805 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:2640 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:2637 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:2638 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:11609 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:17450 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:51504 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:88609 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:88610 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:106099 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:98497 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1858451 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1930638 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:2449818 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:3646373 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:3714859 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:3769707 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:3826 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:628626 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1595919 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:708392 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:628709 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:708379 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
    Paralog (12)
    Structured_description: Concise_description: cyp-13A5 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; loss of cyp-13A5 activity in large-scale RNAi screens results in uncoordinated locomotion, decreased and/or slow growth, and cadmium hypersensitivity. Paper_evidence: WBPaper00005654
            WBPaper00006395
            WBPaper00030811
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8552 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11609)
      DOID:2987 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2637)
      DOID:9952 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:0112251 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11609)
      DOID:0080630 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:10825 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2638)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2637)
  Molecular_info: Corresponding_CDS: T10B9.2
    Corresponding_transcript: T10B9.2.1
    Other_sequence: JI174138.1
      Oden_isotig14710
      Acan_isotig21796
    Associated_feature: WBsf223709
      WBsf223710
  Experimental_info: RNAi_result: WBRNAi00018525 Inferred_automatically: RNAi_primary
      WBRNAi00070152 Inferred_automatically: RNAi_primary
      WBRNAi00053015 Inferred_automatically: RNAi_primary
      WBRNAi00035421 Inferred_automatically: RNAi_primary
      WBRNAi00092623 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1156616
      Expr2010685
      Expr2028924
    Drives_construct: WBCnstr00030481
    Construct_product: WBCnstr00030481
    Microarray_results (14)
    Expression_cluster (327)
    Interaction (36)
  Map_info: Map: II Position: 1.7164 Error: 0.000227
    Positive: Positive_clone: T10B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (7)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene