WormBase Tree Display for Gene: HGNC:51504

HGNC:51504 Identity: Name: CGC_name: CYP3A7-CYP3A51P Inferred_automatically: AGR_import
      Other_name: RGD:9685972
        CYP3A7
        CYP3A7-3AP1
        CYP3A7-CYP3AP1
        CYP3A7-CYP3AP1 readthrough
        CYP3A7.1L
        CYPIIIA7
        cytochrome P450 3A7
        cytochrome P450-HFLA
      Public_name: CYP3A7-CYP3A51P
    DB_info: Database: HGNC id 51504
        AGR cURI HGNC:51504
        EnsEMBL ENSEMBL_geneID ENSG00000282301
            ENSG00000160870
        UniProt UniProt_AC P24462
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog (13)
    Structured_description: Automated_description: This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015] Inferred_automatically: AGR_import