WormBase Tree Display for Gene: WBGene00011305

WBGene00011305 SMap: S_parent: Sequence: R186
  Identity: Version: 2
    Name: CGC_name: hrg-9 Person_evidence: WBPerson15737
      Sequence_name: R186.1
      Molecular_name: R186.1
        R186.1.1
        CE12870
      Other_name: CELE_R186.1 Accession_evidence: NDB BX284605
      Public_name: hrg-9
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Mar 2021 09:37:10 WBPerson1983 Name_change: CGC_name: hrg-9
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hrg
    Allele (32)
    RNASeq_FPKM (74)
    GO_annotation: 00073715
      00073716
      00073717
    Ortholog (34)
    Paralog: WBGene00013587 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to be involved in Golgi organization and protein secretion. Predicted to be located in Golgi apparatus. Is an ortholog of human TANGO2 (transport and golgi organization 2 homolog). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0060413 Homo sapiens Curator_confirmed: WBPerson324
    Potential_model: DOID:0081386 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25439)
    Disease_relevance: 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including TANGO2 (transport and golgi organization 2 homolog); C. elegans R186.1 encodes a putative ortholog of human TANGO2, providing a potential model system to study 22q11.2DS. Homo sapiens Paper_evidence: WBPaper00047004
          Accession_evidence: OMIM 611867
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Sep 2015 00:00:00
  Molecular_info: Corresponding_CDS: R186.1
    Corresponding_transcript: R186.1.1
    Other_sequence (12)
    Associated_feature: WBsf669537
      WBsf1001674
      WBsf1020630
      WBsf234752
  Experimental_info: RNAi_result: WBRNAi00017890 Inferred_automatically: RNAi_primary
      WBRNAi00000725 Inferred_automatically: RNAi_primary
      WBRNAi00052010 Inferred_automatically: RNAi_primary
      WBRNAi00034954 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr16356
      Expr16358
      Expr1019523
      Expr1155650
      Expr2005671
      Expr2023887
    Drives_construct: WBCnstr00030759
      WBCnstr00042972
      WBCnstr00042975
    Construct_product: WBCnstr00030759
      WBCnstr00042975
    Microarray_results (19)
    Expression_cluster: WBPaper00033070:Elbe_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00036738:4uM_Heme_upregulated
      WBPaper00036738:500uM_Heme_upregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045774:clk-1_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048690:hermaphrodite-Z1-Z4_enriched
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050801:SET-4_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051498:zinc-reduction_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:hif-1(ia4)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_upregulated_endo-siRNA_targets
      WBPaper00057162:meg-3_meg-4_upregulated_sRNA
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060764:swsn-1(os22ts)_upregulated
      WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:Intestine
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061527:cyp-14A1-R186.1_5533
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_downregulated_germline
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064158:xpo-1(RNAi)_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065392:Lb.gasseri_upregulated
      WBPaper00065392:Lb.plantarum_upregulated
      WBPaper00065392:Lb.reuteri_upregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_2
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:rde-4_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031703:heme_responsive_5
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00041207:CE_dauer_up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00050407:hsp-6(RNAi)_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_A
    Interaction: WBInteraction000147507
      WBInteraction000182222
      WBInteraction000188676
      WBInteraction000246163
      WBInteraction000274064
      WBInteraction000451741
      WBInteraction000468598
      WBInteraction000468903
  Map_info: Map: V Position: 4.76386
    Positive: Positive_clone: R186 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00064607
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene