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WormBase Tree Display for Gene: WBGene00009813

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Name Class

WBGene00009813SMapS_parentSequenceF47B10
IdentityVersion2
NameCGC_namehaly-1Paper_evidenceWBPaper00038278
Person_evidenceWBPerson341
Sequence_nameF47B10.2
Molecular_name (3)
Other_nameCELE_F47B10.2Accession_evidenceNDBBX284606
Public_namehaly-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:50WBPerson1971EventImportedInitial conversion from CDS class of WS125
212 Apr 2011 11:48:32WBPerson2970Name_changeCGC_namehaly-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhaly
Allele (44)
StrainWBStrain00040582
WBStrain00040583
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (30)
Structured_descriptionConcise_descriptionhaly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions.Paper_evidenceWBPaper00031911
WBPaper00038278
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated04 Apr 2011 00:00:00
Automated_descriptionPredicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0060168Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4806)
Molecular_infoCorresponding_CDSF47B10.2
Corresponding_transcriptF47B10.2.1
Other_sequence (79)
Associated_featureWBsf654368
WBsf237907
WBsf237908
Experimental_infoRNAi_resultWBRNAi00015146Inferred_automaticallyRNAi_primary
WBRNAi00047595Inferred_automaticallyRNAi_primary
WBRNAi00032403Inferred_automaticallyRNAi_primary
Expr_patternChronogram1244
Expr6096
Expr1025610
Expr1034288
Expr1151431
Expr2012363
Expr2030599
Drives_constructWBCnstr00003174
WBCnstr00020173
WBCnstr00031899
Construct_productWBCnstr00020173
WBCnstr00031899
Microarray_results (22)
Expression_clusterWBPaper00029359_1166
WBPaper00029359_1197
WBPaper00029359_1291
WBPaper00029359_1546
WBPaper00029359_1549
WBPaper00029359_1557
WBPaper00029359_1599
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032031:DConiospora_downregulated_OligoArray_24h
WBPaper00032425:down_in_alg-1
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035269:cde-1_regulated
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_embryo_enriched
WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040990:PA14_upregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00045314:S.aureus-induced_N2
WBPaper00045420:fertilization_upregulated_transcript
WBPaper00045521:Spermatogenic
WBPaper00045571:germline-ablation_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046121:ecdoderm_unique
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
WBPaper00049954:BPA_downregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050344:PLM-neuron_enriched
WBPaper00050448:KGB-1-induced
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051388:Glucose-diet_downregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053615:SMO-1_target
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_OP50
WBPaper00053814:25C_upregulated_PY79
WBPaper00054872:egl-9(sa307)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056218:daf-16(mu86)_upregulated_Day3
WBPaper00056218:daf-16(mu86)_upregulated_Day5
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058648:Y37A1B.5(RNAi)_downregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00059117:B.subtilis_downregulated
WBPaper00059253:stearic-acid_downregulated
WBPaper00059605:mut-16(pk710)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060458:rnf-5(tm794)_regulated
WBPaper00060526:plp-1(ok2155)_downregulated
WBPaper00060683:hlh-11(overexpression)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-extract_1h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Tail_hypodermis
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:C18B2.5-haf-4_181
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00063976:micu-1(bon20)_upregulated
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064992:Capsaicin_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
WBPaper00065841:2_0
WBPaper00065841:30_1
WBPaper00065841:30_2
WBPaper00065841:30_5
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066085:hda-3(ok1991)_upregulated
cgc4386_cluster_1_6
cgc4489_group_3
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030985:Enterococcus_faecalis_downregulated
WBPaper00032165:A_to_C_transit_increased
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034757:up_by_oxidative_stress
WBPaper00035227:heat_shock_regulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-7_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035873:osm-11_regulated
WBPaper00035873:osmotically_regulated
WBPaper00035892:KIM5_vs_OP50_Up
WBPaper00035892:Y.pestis_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_G
WBPaper00037695:CC_3-day
WBPaper00038304:octr-1_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040963:Q50_down
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041906:I-3690_vs_OP50_10d
WBPaper00041906:I-4317_vs_OP50_10d
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00045865:biofilm_upregulated_A
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00050767:Octopamine_induced
WBPaper00056330:mrps-5(RNAi)_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (19)
Map_infoMapXPosition2.67922
PositivePositive_cloneF47B10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00031911
WBPaper00038278
WBPaper00038491
WBPaper00039078
WBPaper00045887
WBPaper00055090
WBPaper00063976
WBPaper00064232
WBPaper00065140
WBPaper00065331
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene