nurf-1 encodes the C. elegans ortholog of Drosophila NURF301, a component of the NURF chromatin remodeling complex; in C. elegans, nurf-1 acts with isw-1 to regulate vulval development.
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NURF complex. Expressed in several structures, including head; pharyngeal-intestinal valve; pharynx; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease and amyotrophic lateral sclerosis. Is an ortholog of human BPTF (bromodomain PHD finger transcription factor).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.