WormBase Tree Display for Gene: WBGene00007516

WBGene00007516 SMap: S_parent: Sequence: C11E4
  Identity: Version: 2
    Name: CGC_name: gpx-5 Person_evidence: WBPerson261
      Sequence_name: C11E4.1
      Molecular_name: C11E4.1
        C11E4.1.1
        CE08101
      Other_name: CELE_C11E4.1 Accession_evidence: NDB BX284606
      Public_name: gpx-5
    DB_info: Database: AceView gene XK203
        WormQTL gene WBGene00007516
        WormFlux gene WBGene00007516
        NDB locus_tag CELE_C11E4.1
        Panther gene CAEEL|WormBase=WBGene00007516|UniProtKB=Q93204
          family PTHR11592
        NCBI gene 181178
        RefSeq protein NM_077214.6
        TREEFAM TREEFAM_ID TF105318
        TrEMBL UniProtAcc Q93204
        UniProt_GCRP UniProtAcc Q93204
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Jul 2012 14:20:02 WBPerson2970 Name_change: CGC_name: gpx-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gpx
    Allele (33)
    Strain: WBStrain00002595
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (55)
    Paralog: WBGene00009165 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007517 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00011045 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020373 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00022377 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018850 Caenorhabditis elegans From_analysis: Panther
      WBGene00019846 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: gpx-5 encodes a glutathione peroxidase; by homology, GPX-5 is predicted to function to reduce lipid hydroperoxides to their corresponding alcohols and reduce hydrogen peroxide to water to protect cells from damage induced by reactive oxygen species. Curator_confirmed: WBPerson1843
          Date_last_updated: 28 May 2014 00:00:00
      Automated_description: Predicted to enable glutathione peroxidase activity. Involved in response to reactive oxygen species. Predicted to be located in extracellular space. Expressed in head. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Is an ortholog of human GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:224 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:1184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:285 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:0060060 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:5844 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:3572 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4554)
      DOID:11758 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4554)
      DOID:2527 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:4948 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1287 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:418 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0050083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4554,HGNC:4555)
      DOID:0080797 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1240 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:11713 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:4195 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:1099 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:0050860 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4554,HGNC:4555)
      DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:2355 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:9538 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9408 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:10923 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:2876 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:1993 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:2596 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:0070004 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:7941 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:182 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:10590 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0050731 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:13129 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:2738 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:6713 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9952 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:1596 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:5041 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0060901 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:8552 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4558)
      DOID:9206 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:784 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:3021 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4553,HGNC:4555)
  Molecular_info: Corresponding_CDS: C11E4.1
    Corresponding_CDS_history: C11E4.1:wp83
      C11E4.1:wp178
    Corresponding_transcript: C11E4.1.1
    Other_sequence (80)
    Associated_feature: WBsf648418
      WBsf663182
      WBsf663183
      WBsf1006478
      WBsf1006479
      WBsf1023593
      WBsf236183
  Experimental_info: RNAi_result: WBRNAi00040349 Inferred_automatically: RNAi_primary
      WBRNAi00091322 Inferred_automatically: RNAi_primary
      WBRNAi00040350 Inferred_automatically: RNAi_primary
      WBRNAi00010619 Inferred_automatically: RNAi_primary
      WBRNAi00028806 Inferred_automatically: RNAi_primary
      WBRNAi00115577 Inferred_automatically: RNAi_primary
      WBRNAi00115502 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram759
      Expr5242
      Expr1028068
      Expr1033235
      Expr1144416
      Expr2012219
      Expr2030455
    Drives_construct: WBCnstr00003154
      WBCnstr00033683
    Construct_product: WBCnstr00033683
    Microarray_results (17)
    Expression_cluster (260)
    Interaction: WBInteraction000114668
      WBInteraction000155203
      WBInteraction000519745
      WBInteraction000542764
      WBInteraction000552146
  Map_info: Map: X Position: 1.42294
    Positive: Positive_clone: C11E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00032037
    WBPaper00038491
    WBPaper00039791
    WBPaper00042257
    WBPaper00042271
    WBPaper00045706
    WBPaper00055090
    WBPaper00061220
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene