WormBase Tree Display for Interaction: WBInteraction000542764

WBInteraction000542764 Interaction_type: Regulatory: Change_of_expression_level
  Interactor: Interactor_overlapping_gene: WBGene00003623 Interactor_type: Trans_regulator
      WBGene00004414 Interactor_type: Trans_regulated
      WBGene00017283 Interactor_type: Trans_regulated
      WBGene00007516 Interactor_type: Trans_regulated
      WBGene00001491 Interactor_type: Trans_regulated
      WBGene00001027 Interactor_type: Trans_regulated
  Interaction_summary: "We next measured the changes in the expression of reporter fusions with promoters derived from a total of 14 NHR-25 candidate target genes before and after depletion of NHR-25 in either the larval (Fig. 6, A-Q) or embryonic stage (Fig. 6R). Class 1 and 2 target genes known to be spatially expressed in epidermis were chosen to ensure that at least one NHR-25 peak is located within their promoter sequences (data not shown). Surprisingly, although most of the tested target genes (7 of 14) demonstrated significantly reduced expression, two of them, nekl-3 (Fig. 6, A-D and Q) and idh-1 (Fig. 6Q), showed significantly elevated expression after depletion of NHR-25, indicating both activating and inhibitory roles of NHR-25 in regulating its target activities."
  Detection_method: Reporter_gene: [F09E5.3p::GFP]
  Regulation_level: Transcriptional
  Regulation_result: Positive_regulate: Life_stage: WBls:0000023
      Anatomy_term: WBbt:0005733
  Paper: WBPaper00044288
  Remark: Fig. 6ijklq