WormBase Tree Display for Gene: WBGene00003623
expand all nodes | collapse all nodes | view schema
| WBGene00003623 | Evidence | Paper_evidence | WBPaper00003416 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00004124 | |||||||||
| WBPaper00004329 | |||||||||
| SMap | S_parent | Sequence | F11C1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhr-25 | Person_evidence | WBPerson600 | |||||
| Sequence_name | F11C1.6 | ||||||||
| Molecular_name | F11C1.6a | ||||||||
| F11C1.6a.1 | |||||||||
| CE03191 | |||||||||
| F11C1.6b | |||||||||
| CE35856 | |||||||||
| F11C1.6a.2 | |||||||||
| F11C1.6b.1 | |||||||||
| Other_name | CELE_F11C1.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nhr-25 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (94) | |||||||||
| Legacy_information | [M Asahina] jm2389 is mutagenized using TMP/UV and detected a deletion by PCR. This removes the coding region from Gly40 in the P-box of the first zinc finger motif to Ser377 in the middle of the conserved region II within the LBD (ref. Asahina M et al. 2000 The conserved nuclear receptor Ftz-F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans. Genes to Cells 5: 711). Phenotype is homozygous embryonic lethal at 1.5-fold to 2-fold stage. Balanced with +/szT1[lon-2(e678)] I; nDf19/szT1 X (strain MT1401) | ||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (52) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | nhr-25 encodes a nuclear hormone receptor orthologous to Drosophila Ftz-F1; NHR-25 is required for embryogenesis, molting, vulval and gonadal development, and hypodermal expression of acn-1; nhr-25 is expressed in gonads and loaded into embryos as a maternal transcript; nhr-25 is zygotically expressed in progeny of the E cell, and then in hypodermis and gut; the role of NHR-25 in molting may be evolutionarily conserved between nematodes and arthopods. | Paper_evidence | WBPaper00004329 | |||||
| WBPaper00006295 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables armadillo repeat domain binding activity. Involved in molting cycle and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including excretory system; gonad; hypodermal cell; tail; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Zellweger syndrome; gonadal dysgenesis (multiple); and primary ovarian insufficiency 7. Is an ortholog of human NR5A2 (nuclear receptor subfamily 5 group A member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111764 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7983) | ||||
| DOID:905 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7983) | ||||||
| DOID:0070169 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7983) | ||||||
| DOID:0111772 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7983) | ||||||
| DOID:0080864 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7983) | ||||||
| DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7984) | ||||||
| Molecular_info | Corresponding_CDS | F11C1.6a | |||||||
| F11C1.6b | |||||||||
| Corresponding_transcript | F11C1.6a.1 | ||||||||
| F11C1.6a.2 | |||||||||
| F11C1.6b.1 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature (24) | |||||||||
| Gene_product_binds (378) | |||||||||
| Transcription_factor | WBTranscriptionFactor000597 | ||||||||
| Experimental_info | RNAi_result (143) | ||||||||
| Expr_pattern (27) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product (13) | |||||||||
| Regulate_expr_cluster | WBPaper00045015:nhr-25(RNAi)_downregulated | ||||||||
| WBPaper00045015:nhr-25(RNAi)_upregulated | |||||||||
| Antibody | WBAntibody00000832 | ||||||||
| WBAntibody00002489 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (213) | |||||||||
| Interaction (111) | |||||||||
| Product_binds_matrix | WBPmat00005568 | ||||||||
| WBPmat00005572 | |||||||||
| Map_info | Map | X | Position | 9.49412 | Error | 0.083721 | |||
| Positive | Positive_clone | F11C1 | Person_evidence | WBPerson29 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4522 | |||||||
| 4883 | |||||||||
| 5332 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (96) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
