WormBase Tree Display for Gene: WBGene00007352
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| WBGene00007352 | SMap | S_parent | Sequence | C06A1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | cdc-48.1 | Person_evidence | WBPerson2333 | |||||
| Sequence_name | C06A1.1 | ||||||||
| Molecular_name | C06A1.1 | ||||||||
| C06A1.1.1 | |||||||||
| CE02114 | |||||||||
| Other_name | phi-31 | Person_evidence | WBPerson2582 | ||||||
| CELE_C06A1.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cdc-48.1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:47 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Mar 2005 10:23:45 | WBPerson2970 | Name_change | CGC_name | cdc-48.1 | ||||
| 3 | 17 Mar 2005 13:54:35 | WBPerson2970 | Name_change | Other_name | phi-31 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdc | ||||||||
| Allele (40) | |||||||||
| Strain | WBStrain00007563 | ||||||||
| Component_of_genotype | WBGenotype00000081 | ||||||||
| WBGenotype00000082 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (45) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00003119 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004191 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004195 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00008053 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010562 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013156 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cdc-48.1 encodes a type II AAA ATPase, homologous to yeast Cdc48 and mammalian p97/VCP, that functions as a ubiquitin-selective chaperone; cdc-48.1 acts redundantly with cdc-48.2 and in conjunction with ufd-1 and npl-4 in endoplasmic reticulum-associated protein degradation (ERAD); in addition, CDC-48.1, UFD-2 and chn-1 function together to regulate myosin assembly and muscle formation via the UNC-45 myosin chaperone, and CDC-48.1 and ATX-3 function together in determination of adult lifespan via interaction with the DAF-2-mediated insulin signaling pathway; cdc-48.1 and cdc-48.2 also interact to provide an essential function during embryonic development; CDC-48.1 exhibits ATPase activity in vitro, and in yeast two-hybrid assays, CDC-48.1 interacts with itself, CDC-48.2, ATX-3, UFD-1, and UBXN-1, consistent with studies in yeast and mammals that show CDC48 homologs form homohexameric complexes that interact with adaptor proteins homologous to UFD-1 and UBXN-1. | Paper_evidence | WBPaper00027357 | |||||
| WBPaper00029196 | |||||||||
| WBPaper00032173 | |||||||||
| WBPaper00038133 | |||||||||
| WBPaper00038288 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ER-associated misfolded protein catabolic process; determination of adult lifespan; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. Expressed in several structures, including body wall musculature; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; frontotemporal dementia and/or amyotrophic lateral sclerosis-6; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1. Is an ortholog of human VCP (valosin containing protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:332 | Homo sapiens | Paper_evidence | WBPaper00066343 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 Aug 2021 00:00:00 | ||||||||
| Potential_model | DOID:3429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | |||||
| DOID:0110168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:0060205 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:5408 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:0111385 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:1307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| Models_disease_asserted | WBDOannot00001037 | ||||||||
| Molecular_info | Corresponding_CDS | C06A1.1 | |||||||
| Corresponding_transcript | C06A1.1.1 | ||||||||
| Other_sequence (137) | |||||||||
| Associated_feature | WBsf650510 | ||||||||
| WBsf650511 | |||||||||
| WBsf976316 | |||||||||
| WBsf981271 | |||||||||
| WBsf989393 | |||||||||
| WBsf1013046 | |||||||||
| WBsf223814 | |||||||||
| WBsf223815 | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00005861 | ||||||||
| WBCnstr00008180 | |||||||||
| WBCnstr00011060 | |||||||||
| WBCnstr00011946 | |||||||||
| WBCnstr00012084 | |||||||||
| WBCnstr00033808 | |||||||||
| WBCnstr00042615 | |||||||||
| Construct_product | WBCnstr00005861 | ||||||||
| WBCnstr00006163 | |||||||||
| WBCnstr00006363 | |||||||||
| WBCnstr00008180 | |||||||||
| WBCnstr00011060 | |||||||||
| WBCnstr00011946 | |||||||||
| WBCnstr00012084 | |||||||||
| WBCnstr00033808 | |||||||||
| Antibody | WBAntibody00001256 | ||||||||
| WBAntibody00003045 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (168) | |||||||||
| Interaction (306) | |||||||||
| WBProcess | WBbiopr:00000076 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | II | Position | 3.08111 | Error | 0.00418 | |||
| Positive | Positive_clone | C06A1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5092 | |||||||
| Pseudo_map_position | |||||||||
| Reference (47) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
