WormBase Tree Display for Gene: WBGene00007352
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WBGene00007352 | SMap | S_parent | Sequence | C06A1 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | cdc-48.1 | Person_evidence | WBPerson2333 | |||
Sequence_name | C06A1.1 | ||||||
Molecular_name | C06A1.1 | ||||||
C06A1.1.1 | |||||||
CE02114 | |||||||
Other_name | phi-31 | Person_evidence | WBPerson2582 | ||||
CELE_C06A1.1 | Accession_evidence | NDB | BX284602 | ||||
Public_name | cdc-48.1 | ||||||
DB_info | Database (13) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cdc | ||||||
Allele (40) | |||||||
Strain | WBStrain00007563 | ||||||
Component_of_genotype | WBGenotype00000081 | ||||||
WBGenotype00000082 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (45) | |||||||
Ortholog (41) | |||||||
Paralog | WBGene00003119 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00004191 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004195 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00008053 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00010562 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00013156 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | cdc-48.1 encodes a type II AAA ATPase, homologous to yeast Cdc48 and mammalian p97/VCP, that functions as a ubiquitin-selective chaperone; cdc-48.1 acts redundantly with cdc-48.2 and in conjunction with ufd-1 and npl-4 in endoplasmic reticulum-associated protein degradation (ERAD); in addition, CDC-48.1, UFD-2 and chn-1 function together to regulate myosin assembly and muscle formation via the UNC-45 myosin chaperone, and CDC-48.1 and ATX-3 function together in determination of adult lifespan via interaction with the DAF-2-mediated insulin signaling pathway; cdc-48.1 and cdc-48.2 also interact to provide an essential function during embryonic development; CDC-48.1 exhibits ATPase activity in vitro, and in yeast two-hybrid assays, CDC-48.1 interacts with itself, CDC-48.2, ATX-3, UFD-1, and UBXN-1, consistent with studies in yeast and mammals that show CDC48 homologs form homohexameric complexes that interact with adaptor proteins homologous to UFD-1 and UBXN-1. | Paper_evidence | WBPaper00027357 | |||
WBPaper00029196 | |||||||
WBPaper00032173 | |||||||
WBPaper00038133 | |||||||
WBPaper00038288 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 05 Apr 2011 00:00:00 | ||||||
Automated_description | Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ER-associated misfolded protein catabolic process; determination of adult lifespan; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. Expressed in several structures, including body wall musculature; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; frontotemporal dementia and/or amyotrophic lateral sclerosis-6; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1. Is an ortholog of human VCP (valosin containing protein). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:332 | Homo sapiens | Paper_evidence | WBPaper00066343 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 31 Aug 2021 00:00:00 | ||||||
Potential_model | DOID:3429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | |||
DOID:0110168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||
DOID:0060205 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||
DOID:5408 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||
DOID:0111385 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||
DOID:1307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||
Models_disease_asserted | WBDOannot00001037 | ||||||
Molecular_info | Corresponding_CDS | C06A1.1 | |||||
Corresponding_transcript | C06A1.1.1 | ||||||
Other_sequence (137) | |||||||
Associated_feature | WBsf650510 | ||||||
WBsf650511 | |||||||
WBsf976316 | |||||||
WBsf981271 | |||||||
WBsf989393 | |||||||
WBsf1013046 | |||||||
WBsf223814 | |||||||
WBsf223815 | |||||||
Experimental_info | RNAi_result (40) | ||||||
Expr_pattern (15) | |||||||
Drives_construct | WBCnstr00005861 | ||||||
WBCnstr00008180 | |||||||
WBCnstr00011060 | |||||||
WBCnstr00011946 | |||||||
WBCnstr00012084 | |||||||
WBCnstr00033808 | |||||||
WBCnstr00042615 | |||||||
Construct_product | WBCnstr00005861 | ||||||
WBCnstr00006163 | |||||||
WBCnstr00006363 | |||||||
WBCnstr00008180 | |||||||
WBCnstr00011060 | |||||||
WBCnstr00011946 | |||||||
WBCnstr00012084 | |||||||
WBCnstr00033808 | |||||||
Antibody | WBAntibody00001256 | ||||||
WBAntibody00003045 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (168) | |||||||
Interaction (306) | |||||||
WBProcess | WBbiopr:00000076 | ||||||
WBbiopr:00000079 | |||||||
Map_info | Map | II | Position | 3.08111 | Error | 0.00418 | |
Positive | Positive_clone | C06A1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5092 | |||||
Pseudo_map_position | |||||||
Reference (47) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |