WormBase Tree Display for Gene: WBGene00008053
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| WBGene00008053 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cdc-48.2 | Person_evidence | WBPerson2333 | |||||
| Sequence_name | C41C4.8 | ||||||||
| Molecular_name | C41C4.8 | ||||||||
| C41C4.8.1 | |||||||||
| CE05402 | |||||||||
| Other_name | CELE_C41C4.8 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cdc-48.2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Mar 2005 10:23:45 | WBPerson2970 | Name_change | CGC_name | cdc-48.2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdc | ||||||||
| Allele (40) | |||||||||
| Strain | WBStrain00007566 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00003119 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004191 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004195 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007352 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010562 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013156 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cdc-48.2 encodes a AAA (ATPase associated with various cellular activities) ATPase that is one of two C. elegans p97/VCP/CDC48 homologs; cdc-48.2 acts redundantly with cdc-48.1 in endoplasmic reticulum-associated protein degradation (ERAD); in addition, cdc-48.1 and cdc-48.2 together provide an essential function during embryonic development; CDC-48.2 exhibits ATPase activity when expressed in vitro, and in yeast two-hybrid assays, CDC-48.2 interacts with itself, CDC-48.1, UFD-1, and UBXN-1, consistent with studies in yeast and mammals that show CDC48 homologs form homohexameric complexes that interact with adaptor proteins homologous to UFD-1 and UBXN-1. | Paper_evidence | WBPaper00027357 | |||||
| WBPaper00032173 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ER-associated misfolded protein catabolic process; negative regulation of protein localization to centrosome; and protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Expressed in body wall musculature and germ line. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; frontotemporal dementia and/or amyotrophic lateral sclerosis-6; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1. Is an ortholog of human VCP (valosin containing protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||
| DOID:0110168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:0060205 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:5408 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:0111385 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| DOID:1307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12666) | ||||||
| Molecular_info | Corresponding_CDS | C41C4.8 | |||||||
| Corresponding_transcript | C41C4.8.1 | ||||||||
| Other_sequence (103) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (35) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00008179 | ||||||||
| WBCnstr00011058 | |||||||||
| WBCnstr00011947 | |||||||||
| WBCnstr00012085 | |||||||||
| WBCnstr00033273 | |||||||||
| WBCnstr00042616 | |||||||||
| Construct_product | WBCnstr00006163 | ||||||||
| WBCnstr00006366 | |||||||||
| WBCnstr00006367 | |||||||||
| WBCnstr00008179 | |||||||||
| WBCnstr00011058 | |||||||||
| WBCnstr00011947 | |||||||||
| WBCnstr00012085 | |||||||||
| WBCnstr00016670 | |||||||||
| WBCnstr00033273 | |||||||||
| Regulate_expr_cluster | WBPaper00046421:cdc-48.2(tm659)_upregulated | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (176) | |||||||||
| Interaction (484) | |||||||||
| WBProcess | WBbiopr:00000076 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | II | Position | 0.708325 | Error | 0.00124 | |||
| Positive | Positive_clone | C41C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5088 | |||||||
| 5061 | |||||||||
| 5502 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (43) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
