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WormBase Tree Display for Gene: WBGene00006957

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Name Class

WBGene00006957EvidencePaper_evidenceWBPaper00005843
SMapS_parentSequenceC07G1
IdentityVersion1
NameCGC_namewsp-1Person_evidenceWBPerson633
Sequence_nameC07G1.4
Molecular_nameC07G1.4a
C07G1.4a.1
CE32572
C07G1.4b
CE32573
C07G1.4b.1
Other_nameCELE_C07G1.4Accession_evidenceNDBBX284604
Public_namewsp-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:44WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classwsp
Allele (146)
StrainWBStrain00002469
WBStrain00028743
WBStrain00007551
WBStrain00007878
RNASeq_FPKM (74)
GO_annotation (29)
Contained_in_operonCEOP4274
Ortholog (19)
ParalogWBGene00015100Caenorhabditis elegansFrom_analysisTreeFam
Panther
WBGene00007840Caenorhabditis elegansFrom_analysisTreeFam
Panther
WBGene00020094Caenorhabditis elegansFrom_analysisPanther
WBGene00015107Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptionwsp-1 encodes the C. elegans WASP ortholog; when mutated, human WASP leads to Wiskott-Aldrich syndrome (OMIM:301000); wsp-1 is required for hypodermal cell migration during morphogenesis (ventral enclosure); in a yeast two-hybrid assay WSP-1 physically interacts with WIP-1, the C. elegans WASP-interacting protein ortholog; WSP-1 and WIP-1 are mutually required for normal protein levels; WSP-1 is found in migrating hypodermal cells during ventral enclosure.Paper_evidenceWBPaper00004103
WBPaper00005843
WBPaper00027006
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated29 May 2013 00:00:00
Automated_descriptionEnables cytoskeletal regulatory protein binding activity and small GTPase binding activity. Involved in several processes, including embryonic morphogenesis; positive regulation of egg-laying behavior; and regulation of cellular component organization. Located in cell leading edge; cortical actin cytoskeleton; and presynaptic periactive zone. Expressed in Q cell; anchor cell; apoptotic cell; epithelial cell; and hypodermis. Is an ortholog of human WASL (WASP like actin nucleation promoting factor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC07G1.4a
C07G1.4b
Corresponding_CDS_historyC07G1.4a:wp90
C07G1.4b:wp90
Corresponding_transcriptC07G1.4a.1
C07G1.4b.1
Other_sequence (30)
Associated_featureWBsf668088
WBsf668089
WBsf668090
WBsf668091
WBsf668092
WBsf997157
WBsf997158
WBsf1017812
WBsf230394
WBsf230395
Experimental_infoRNAi_result (17)
Expr_pattern (13)
Drives_constructWBCnstr00004412
WBCnstr00022478
WBCnstr00034071
Construct_product (14)
AntibodyWBAntibody00000620
WBAntibody00000753
WBAntibody00000754
Microarray_results (27)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00035211:age-1_vs_age-1_downregulated
WBPaper00035211:age-1_vs_N2_downregulated
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037682:sma-2_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00048988:neuron_expressed
WBPaper00049018:SWSN-2.2_interacting
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050686:glp-1(e2141)_downregulated
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_specific
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00059598:HeatShock_upregulated
WBPaper00059763:neuron_expressed
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061340:Anterior_arcade_cell
WBPaper00061340:Pharyngeal_intestinal_valve
WBPaper00061340:Posterior_arcade_cell
WBPaper00061527:mbk-2_1585-tol-1_22538
WBPaper00061527:npp-8_2951-rme-8_3001
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_5_1
cgc4489_group_25
WBPaper00025032:cluster_6
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030985:Serratia_marcesens_upregulated
WBPaper00031252:AIN-2_IP_enriched
WBPaper00034757:down_by_oxidative_stress
WBPaper00035905:FBF-1_Associated
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040963:TA100_down
WBPaper00040963:TA300_down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042331:a-SWCNTs_downregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:intrinsic
Interaction (128)
Map_infoMapIVPosition3.65746Error0.002507
PositivePositive_cloneC07G1Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4994
5010
4600
Pseudo_map_position
Reference (51)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene