WormBase Tree Display for Gene: WBGene00006890

WBGene00006890 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: K07E3
  Identity: Version: 1
    Name: CGC_name: vem-1 Person_evidence: WBPerson1835
      Sequence_name: K07E3.8
      Molecular_name: K07E3.8
        K07E3.8.1
        CE34578
      Other_name: CELE_K07E3.8 Accession_evidence: NDB BX284606
      Public_name: vem-1
    DB_info: Database: AceView gene XI706
        WormQTL gene WBGene00006890
        WormFlux gene WBGene00006890
        NDB locus_tag CELE_K07E3.8
        Panther gene CAEEL|WormBase=WBGene00006890|UniProtKB=Q7YZW5
          family PTHR10281
        NCBI gene 181066
        RefSeq protein NM_001029599.11
        SwissProt UniProtAcc Q7YZW5
        UniProt_GCRP UniProtAcc Q7YZW5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vem
    Allele (34)
    Strain: WBStrain00035774
      WBStrain00035993
    RNASeq_FPKM (74)
    GO_annotation: 00082942
      00082943
      00082944
      00082945
      00082946
      00082947
      00082948
      00082949
      00082950
      00082951
    Ortholog (41)
    Paralog: WBGene00006478 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012559 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: vem-1 encodes a transmembrane protein that contains a cytochrome b5-like heme/steroid-binding domain and is orthologous to mammalian VEMA, a membrane-associated progesterone receptor component; in C. elegans, vem-1 is required for proper axonal guidance of ventral nerve cord neurons; vem-1 interacts genetically with unc-40, whose protein product also interacts with VEM-1; a VEM-1::GFP reporter fusion is expressed from embryonic stages through late larval stages and is found in a subset of neurons, including the AVG pioneer neurons, that extend processes into the ventral nerve cord; microarray experiments indicate that vem-1 transcripts are upregulated in response to treatment with xenobiotics such as clofibrate and beta-naphthoflavone. Paper_evidence: WBPaper00024484
            WBPaper00026820
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Involved in innate immune response. Located in axon. Expressed in AVG; head neurons; and somatic nervous system. Is an ortholog of human PGRMC1 (progesterone receptor membrane component 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K07E3.8
    Corresponding_CDS_history: K07E3.8a:wp252
    Corresponding_transcript: K07E3.8.1
    Other_sequence (28)
    Associated_feature: WBsf654188
      WBsf654189
      WBsf654190
      WBsf654191
      WBsf670808
      WBsf982206
      WBsf1006049
  Experimental_info: RNAi_result: WBRNAi00061111 Inferred_automatically: RNAi_primary
      WBRNAi00050171 Inferred_automatically: RNAi_primary
      WBRNAi00061112 Inferred_automatically: RNAi_primary
      WBRNAi00016735 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3106
      Expr1011310
      Expr1032922
      Expr1153866
      Expr2017966
      Expr2036102
    Drives_construct: WBCnstr00001989
      WBCnstr00034111
    Construct_product: WBCnstr00034111
    Microarray_results (22)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00032976:non_compensated_genes
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048926:miaserin_upregulated_adult-day3
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00048988:neuron_expressed
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050561:indole_10-fold_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058599:benzimidazoles_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:AMsh
      WBPaper00061340:ant_arc_V
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:T
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:vem-1-ugt-58
      WBPaper00061590:CGP37157_upregulated
      WBPaper00061651:BAG_enriched
      WBPaper00061651:PHsh_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064291:antimycin_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065841:15_0
      WBPaper00065841:21_0
      WBPaper00065841:21_1
      WBPaper00065841:85_0
      WBPaper00065849:ursolic-acid_regulated
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00036286:Pattern_I
      WBPaper00037113:CPF_16C_up-regulated
      WBPaper00037704:ABZ_up_regulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041211:RPW-24_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_3h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00050407:hsp-6(RNAi)_upregulated
      WBPaper00055899:2,4-Dinitroanisole_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc5976]:class_1
    Interaction (20)
  Map_info: Map: X Position: -0.581887 Error: 0.008927
    Positive: Positive_clone: K07E3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4259
        4404
        4750
    Pseudo_map_position
  Reference: WBPaper00018032
    WBPaper00024484
    WBPaper00026820
    WBPaper00033099
    WBPaper00038491
    WBPaper00048021
    WBPaper00050498
    WBPaper00055090
  Remark: Sequence connection from [Runko E, Kaprielian Z]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene