WormBase Tree Display for Gene: WBGene00006868

WBGene00006868 SMap: S_parent: Sequence: M03A1
  Identity: Version: 1
    Name: CGC_name: vab-1 Person_evidence: WBPerson261
      Sequence_name: M03A1.1
      Molecular_name: M03A1.1
        M03A1.1.1
        CE25060
      Other_name: CELE_M03A1.1 Accession_evidence: NDB BX284602
      Public_name: vab-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vab
    Reference_allele: WBVar00142901
    Allele: WBVar00142887 Inferred_automatically (12)
      WBVar00144496 Inferred_automatically: From strain object: CZ5686
          From strain object: CZ7112
          From strain object: CZ793
          From strain object: CZ910
      WBVar00143429
      WBVar00142973
      WBVar00142974
      WBVar00143031
      WBVar00142880
      WBVar02124990
      WBVar00726702
      WBVar00726703
      WBVar02108821
      WBVar00726704
      WBVar01499702
      WBVar00726705
      WBVar02129815
      WBVar00726706
      WBVar02129816
      WBVar00726707
      WBVar02129817
      WBVar02129818
      WBVar00726708
      WBVar00726709
      WBVar00726710
      WBVar00726711
      WBVar00726712
      WBVar00726713
      WBVar00143543
      WBVar00726714
      WBVar00726715
      WBVar00726716
      WBVar00726717
      WBVar00726718
      WBVar00726719
      WBVar01413402
      WBVar00726720
      WBVar01413404
      WBVar00726721
      WBVar01413405
      WBVar00726722
      WBVar01413406
      WBVar00726723
      WBVar00726724
      WBVar01413408
      WBVar00726725
      WBVar01498435
      WBVar00726726
      WBVar00726727
      WBVar00726728
      WBVar00726729
      WBVar00726730
      WBVar00726731
      WBVar00088139
      WBVar00726732
      WBVar00726733
      WBVar01559419
      WBVar01559420
      WBVar01492739
      WBVar00726734
      WBVar01559421
      WBVar00726735
      WBVar01492740
      WBVar00726736
      WBVar01559422
      WBVar01719575
      WBVar00726737
      WBVar01559423
      WBVar01719576
      WBVar02109776
      WBVar01559424
      WBVar00726738
      WBVar01719577
      WBVar01993939
      WBVar01719578
      WBVar00143715
      WBVar01559425
      WBVar00726739
      WBVar01559426
      WBVar00726740
      WBVar01248451
      WBVar00726741
      WBVar01559427
      WBVar01559428
      WBVar00726742
      WBVar01559429
      WBVar02055654
      WBVar00726743
      WBVar01916681
      WBVar01934598
      WBVar00726744
      WBVar00726745
      WBVar01934599
      WBVar01916682
      WBVar00142901
      WBVar00726746
      WBVar01400064
      WBVar01393568
      WBVar00726747
      WBVar00726748
      WBVar01393569
      WBVar02108130
      WBVar00726749
      WBVar00726750
      WBVar01248462
      WBVar00726751
      WBVar02017868
      WBVar00550253
      WBVar00726752
      WBVar01371900
      WBVar00550254
      WBVar01305825
      WBVar00726753
      WBVar01371911
      WBVar00726754
      WBVar01305826
      WBVar00550255
      WBVar01371922
      WBVar00726755
      WBVar00550256
      WBVar00726756
      WBVar01305832
      WBVar00550258
      WBVar01305833
      WBVar00726757
      WBVar01371934
      WBVar00550260
      WBVar01603719
      WBVar01305834
      WBVar00726758
      WBVar00550264
      WBVar01248474
      WBVar00550265
      WBVar00726759
      WBVar01305836
      WBVar01603720
      WBVar00260074
      WBVar01305847
      WBVar01603721
      WBVar01371945
      WBVar00550266
      WBVar00726760
      WBVar01371956
      WBVar01305848
      WBVar01603722
      WBVar00726761
      WBVar00550267
      WBVar00550268
      WBVar00726762
      WBVar01305849
      WBVar01603723
      WBVar00550269
      WBVar01305853
      WBVar00726763
      WBVar01603724
      WBVar00726764
      WBVar01603725
      WBVar01371967
      WBVar00550274
      WBVar01305854
      WBVar00726765
      WBVar01603726
      WBVar01305855
      WBVar00726766
      WBVar01603727
      WBVar01239356
      WBVar01305856
      WBVar00726767
      WBVar01371978
      WBVar01305857
      WBVar00726768
      WBVar01305862
      WBVar01305865
      WBVar00726769
      WBVar01371989
      WBVar01248485
      WBVar01372000
      WBVar00364328
      WBVar01305880
      WBVar00726770
      WBVar00726771
      WBVar02002646
      WBVar00364329
      WBVar01372011
      WBVar00364330
      WBVar00092905
      WBVar00726772
      WBVar00364331
      WBVar00726773
      WBVar00726774
      WBVar01404978
      WBVar00364332
      WBVar02106498
      WBVar02029198
      WBVar00726775
      WBVar02029199
      WBVar00364333
      WBVar01248496
      WBVar02029200
      WBVar00726776
      WBVar00364334
      WBVar01792107
      WBVar00726777
      WBVar02089205
      WBVar02029201
      WBVar00364335
      WBVar00364336
      WBVar00726778
      WBVar00726779
      WBVar00364337
      WBVar01248507
      WBVar00364338
      WBVar00726780
      WBVar00726781
      WBVar00364339
      WBVar00726782
      WBVar00364340
      WBVar00726783
      WBVar00364341
      WBVar00364342
      WBVar00726784
      WBVar00364343
      WBVar00726785
      WBVar00726786
      WBVar00364344
      WBVar00364345
      WBVar01248518
      WBVar00726787
      WBVar00726788
      WBVar00364346
      WBVar00726789
      WBVar00364347
      WBVar00364348
      WBVar00171625
      WBVar00726790
      WBVar00364349
      WBVar00726791
      WBVar00222916
      WBVar00171626
      WBVar00364350
      WBVar00726792
      WBVar00222917
      WBVar00171627
      WBVar01248529
      WBVar00726793
      WBVar00364351
      WBVar00222918
      WBVar00171628
      WBVar00171629
      WBVar00222919
      WBVar00726794
      WBVar00364352
      WBVar00364353
      WBVar00171630
      WBVar00726795
      WBVar00222920
      WBVar01248540
      WBVar00171631
      WBVar00726796
      WBVar00364354
      WBVar00222921
      WBVar00314483
      WBVar01248551
      WBVar00171632
      WBVar00726797
      WBVar00222922
      WBVar00364355
      WBVar00171633
      WBVar00222923
      WBVar00364356
      WBVar00726798
      WBVar00726799
      WBVar00364357
      WBVar00171634
      WBVar00171635
      WBVar00364358
      WBVar00726800
      WBVar00726801
      WBVar00364359
      WBVar00171636
      WBVar00726802
      WBVar01943360
      WBVar00364360
      WBVar00171637
      WBVar00171638
      WBVar00364361
      WBVar00726803
      WBVar00726804
      WBVar00364362
      WBVar00171639
      WBVar01248562
      WBVar00364363
      WBVar01895039
      WBVar00726805
      WBVar00171640
      WBVar02087393
      WBVar00364364
      WBVar00171641
      WBVar02087394
      WBVar00726806
      WBVar01437531
      WBVar00171643
      WBVar00364365
      WBVar02087395
      WBVar01437532
      WBVar00726807
      WBVar00726808
      WBVar00364366
      WBVar01437533
      WBVar00171644
      WBVar00726809
      WBVar01437534
      WBVar00364367
      WBVar00171645
      WBVar00171646
      WBVar00726810
      WBVar00364368
      WBVar01437538
      WBVar00171647
      WBVar01949020
      WBVar01437539
      WBVar00726811
      WBVar01248573
      WBVar00171648
      WBVar01949021
      WBVar01437540
      WBVar00726812
      WBVar00726813
      WBVar01949022
      WBVar00171649
      WBVar01437541
      WBVar00726814
      WBVar01949023
      WBVar01437542
      WBVar00171650
      WBVar01949024
      WBVar01836110
      WBVar00171651
      WBVar01437543
      WBVar00726815
      WBVar01949025
      WBVar01437544
      WBVar00726816
      WBVar01949026
      WBVar00726817
      WBVar01949027
      WBVar00726818
      WBVar00726819
      WBVar01494481
      WBVar00726820
      WBVar02033165
      WBVar00726821
      WBVar00726822
      WBVar02033166
      WBVar01959943
      WBVar00726823
      WBVar00726824
      WBVar01959946
      WBVar01959947
      WBVar01959949
      WBVar01959953
      WBVar01823140
      WBVar01959955
      WBVar00276994
      WBVar01959960
      WBVar01959962
      WBVar01959963
      WBVar01626490
      WBVar02076345
      WBVar01783113
      WBVar01783114
      WBVar01783115
      WBVar00103630
      WBVar01505000
      WBVar00103631
      WBVar01477404
      WBVar02124985
      WBVar02068148
      WBVar01477405
      WBVar02124986
      WBVar01477406
      WBVar02124987
      WBVar01477407
      WBVar02124988
      WBVar01371231
      WBVar01477408
      WBVar01495072
      WBVar01371232
      WBVar02124989
      WBVar02124991
      WBVar00260915
      WBVar01817642
      WBVar00726684
      WBVar00726685
      WBVar00726686
      WBVar01576916
      WBVar00726687
      WBVar02096660
      WBVar00726688
      WBVar01576917
      WBVar01576918
      WBVar00726689
      WBVar00726690
      WBVar01982406
      WBVar01576919
      WBVar00726691
      WBVar01576920
      WBVar00726692
      WBVar01576921
      WBVar00726693
      WBVar01576922
      WBVar00726694
      WBVar00726695
      WBVar00726696
      WBVar00726697
      WBVar00726698
      WBVar00726699
      WBVar00143415
      WBVar00726700
      WBVar00726701
    Legacy_information: e2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%).
      See also e2, e116, e118, e200, e699, e721, e1063, e2027
      [C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ]
    Strain (24)
    RNASeq_FPKM (74)
    GO_annotation (38)
    Ortholog (113)
    Paralog (69)
    Structured_description: Concise_description: vab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad. Paper_evidence: WBPaper00003020
            WBPaper00003843
            WBPaper00005670
            WBPaper00027013
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Feb 2007 00:00:00
      Automated_description: Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (14)
  Molecular_info: Corresponding_CDS: M03A1.1
    Corresponding_CDS_history: M03A1.1b:wp274
    Corresponding_transcript: M03A1.1.1
    Other_sequence (11)
    Associated_feature (54)
  Experimental_info: RNAi_result (27)
    Expr_pattern (16)
    Drives_construct: WBCnstr00000707
      WBCnstr00006419
      WBCnstr00009616
      WBCnstr00018076
      WBCnstr00034120
      WBCnstr00042438
    Construct_product (15)
    Antibody: WBAntibody00000876
      WBAntibody00001049
      WBAntibody00001576
      WBAntibody00002037
      WBAntibody00002313
    Microarray_results (28)
    Expression_cluster (158)
    Interaction (248)
    Anatomy_function: WBbtf0217
      WBbtf0220
    WBProcess: WBbiopr:00000001
      WBbiopr:00000068
      WBbiopr:00000120
  Map_info: Map: II Position: -3.85469 Error: 0.013028
    Well_ordered
    Positive: Inside_rearr: mDf14
        mDf15
      Positive_clone: M03A1 Person_evidence: WBPerson105
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 266
      Multi_point: 48
        881
        882
        1880
        4031
        4032
      Pos_neg_data (12)
  Reference (154)
  Method: Gene