WormBase Tree Display for Variation: WBVar00143415

WBVar00143415 Evidence: Paper_evidence: WBPaper00003865
  Name: Public_name: e699
    Other_name: CE25060:p.Thr63Ile
      M03A1.1.1:c.188C>T
    HGVSg: CHROMOSOME_II:g.4578134C>T
  Sequence_details: SMap: S_parent: Sequence: M03A1
    Flanking_sequences: atatgatcaattttcagtggatggaagaaa ttggcgaaatccagcggcgacagacgagaa
    Mapping_target: M03A1
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00003865
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005349
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006868
      WBGene00305535
    Transcript: M03A1.1.1 (12)
      M03A1.13
    Interactor (48)
  Genetics: Interpolated_map_position: II -3.86415
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00031951
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited ~10% embryonic lethality (N=2222). Paper_evidence: WBPaper00031951
            Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were reared on NA22 bacteria instead of OP50. Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
          Temperature: 20 Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
      WBPhenotype:0000054 Paper_evidence: WBPaper00031951
        Curator_confirmed: WBPerson712
        Remark: N=2222 Paper_evidence: WBPaper00031951
            Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000023 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were reared on NA22 bacteria instead of OP50. Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
          Temperature: 20 Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
      WBPhenotype:0000195 Paper_evidence: WBPaper00031951
        Curator_confirmed: WBPerson712
        Remark: Animals showed weak defects in DTC migration along the ventral body wall muscle between the hyp7 hypodermal syncytium (phase 1) and more defects during the migration along the dorsal body wall muscle (phase 3), but not while crossing hyp7 (phase 2), as visualized by lag-2::GFP expression. Paper_evidence: WBPaper00031951
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006865 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000035 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
            WBls:0000038 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
          GO_term: GO:0016477 PATO:0000460 Paper_evidence: WBPaper00031951
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were reared on NA22 bacteria instead of OP50. Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
          Temperature: 20 Paper_evidence: WBPaper00031951
              Curator_confirmed: WBPerson712
      WBPhenotype:0002045 Paper_evidence: WBPaper00040629
        Curator_confirmed: WBPerson712
        Remark: Mutants show decreased germ-cell corpse numbers. Paper_evidence: WBPaper00040629
            Curator_confirmed: WBPerson712
  Reference: WBPaper00040629
    WBPaper00031951
  Method: Substitution_allele