WormBase Tree Display for Variation: WBVar00142887

WBVar00142887 Name: Public_name: dx31
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (12)
    Laboratory: EJ
    Status: Live
  Affects: Gene: WBGene00006868
    Interactor (12)
  Description: Phenotype (26)
    Phenotype_not_observed: WBPhenotype:0000114 Paper_evidence: WBPaper00035407
        Curator_confirmed: WBPerson2021
        Remark: daf-18/pten transcript levels are not affected in a vab-1(dx31) mutant background Paper_evidence: WBPaper00035407
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035407
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: RT PCR Paper_evidence: WBPaper00035407
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000186 Paper_evidence: WBPaper00040629
        Curator_confirmed: WBPerson712
        Remark: vab-1(dx31) mutants showed a slight increase in mature oocytes, although this was not significant. Paper_evidence: WBPaper00040629
            Curator_confirmed: WBPerson712
      WBPhenotype:0000424 Paper_evidence: WBPaper00040629
        Curator_confirmed: WBPerson712
        Remark: Two regions of MPK-1 (dpMPK-1) immunoreactivity were observed strong fluorescence in mature oocytes, and less intense but reproducible fluorescence preceding the gonad bend. In the apoptotic region a modest decrease in the mean fluorescence and the length of the signaling zone in vab-1 mutants was observed when compared with the N2 wild type, but these differences were not statistically significant. Paper_evidence: WBPaper00040629
            Curator_confirmed: WBPerson712
      WBPhenotype:0000684 Paper_evidence: WBPaper00040629
        Curator_confirmed: WBPerson712
        Remark: Loss of vab-1 activity had no statistically significant impact on germ-cell numbers at any stage of development. Paper_evidence: WBPaper00040629
            Curator_confirmed: WBPerson712
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
  Disease_info: Modifies_disease: DOID:162
    Modifies_disease_in_annotation: WBDOannot00000548
  Reference (14)
  Method: Allele