WormBase Tree Display for Gene: WBGene00006839

WBGene00006839 SMap: S_parent: Sequence: F09B9
  Identity: Version: 1
    Name: CGC_name: unc-115 Person_evidence: WBPerson261
      Sequence_name: F09B9.2
      Molecular_name: F09B9.2a
        F09B9.2a.1
        CE15759
        F09B9.2b
        CE02176
        F09B9.2b.1
      Other_name: CELE_F09B9.2 Accession_evidence: NDB BX284606
      Public_name: unc-115
    DB_info: Database: AceView gene XK771
        WormQTL gene WBGene00006839
        WormFlux gene WBGene00006839
        NDB locus_tag CELE_F09B9.2
        Panther gene CAEEL|WormBase=WBGene00006839|UniProtKB=Q95QM5
          family PTHR24213
        NCBI gene 181227
        RefSeq protein NM_077301.9
            NM_001029371.8
        TREEFAM TREEFAM_ID TF318042
        TrEMBL UniProtAcc Q95QM5
            Q19240
        UniProt_GCRP UniProtAcc Q95QM5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (111)
    Legacy_information: See also e2225
      [C.elegansII] e2225mut : uncoordinated movement, severe kinker. Muscle structure appears normal. OA1: mn481. Cloned: predicted protein has N-term LIMb domain, C-term villin headpiece similarity. [FF; SP]
    Strain: WBStrain00003646
      WBStrain00027092
      WBStrain00030542
      WBStrain00034392
      WBStrain00034399
      WBStrain00037520
      WBStrain00005032
      WBStrain00005254
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (39)
    Structured_description: Concise_description: unc-115 encodes a protein that binds actin filaments and that is required for RAS signalling and UNC-40/netrin activity during axon pathfinding. Paper_evidence: WBPaper00005607
            WBPaper00005719
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity. Involved in neuron projection morphogenesis; regulation of filopodium assembly; and regulation of lamellipodium assembly. Located in basal plasma membrane and cytoplasm. Expressed in several structures, including PDE; excretory cell; pharynx; somatic nervous system; and vulva. Is an ortholog of human ABLIM2 (actin binding LIM protein family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F09B9.2a
      F09B9.2b
    Corresponding_transcript: F09B9.2a.1
      F09B9.2b.1
    Other_sequence (45)
    Associated_feature (16)
    Transcription_factor: WBTranscriptionFactor000712
  Experimental_info: RNAi_result (17)
    Expr_pattern (11)
    Drives_construct (12)
    Construct_product: WBCnstr00007698
      WBCnstr00018995
      WBCnstr00020818
      WBCnstr00034126
    Antibody: WBAntibody00001164
    Microarray_results (29)
    Expression_cluster: WBPaper00029359_1142
      WBPaper00029359_1217
      WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00032976:dosage_compensated_genes
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041222:hlh-1(cc561)_upregulated
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ALN
      WBPaper00061340:AVB
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:RIV
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:hlh-30_18579-unc-43_21739
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061651:AVA_enriched
      WBPaper00061651:AVF_enriched
      WBPaper00061651:AVG_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:AVK_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB01_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:FLP_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:PDB_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VC_4_5_enriched
      WBPaper00061651:VC_enriched
      WBPaper00061651:VD_DD_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_5_5
      cgc4489_group_8
      WBPaper00025032:cluster_18
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:WC_5-day
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00053236:Starvation_regulated_GR1307
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_C
    Interaction (85)
    Anatomy_function: WBbtf0223
  Map_info: Map: X Position: 1.86244 Error: 0.006291
    Well_ordered
    Positive: Positive_clone: F09B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 3647
        3648
        3654
        3657
        3660
        3662
        3666
        6011
        7020
        7022
      Multi_point (31)
      Pos_neg_data: 3650
        3665
        6695
  Reference (76)
  Method: Gene