WormBase Tree Display for Gene: WBGene00006830

WBGene00006830 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 2
    Name: CGC_name: unc-103 Person_evidence: WBPerson261
      Sequence_name: C30D11.1
      Molecular_name (57)
      Other_name: CELE_C30D11.1 Accession_evidence: NDB BX284603
      Public_name: unc-103
    DB_info: Database: WormQTL gene WBGene00006830
        WormFlux gene WBGene00006830
        NDB locus_tag CELE_C30D11.1
        Panther gene CAEEL|WormBase=WBGene00006830|UniProtKB=G5EFJ9
          family PTHR10217
        NCBI gene 175527
        RefSeq protein (19)
        SwissProt UniProtAcc G5EFJ9
        TrEMBL UniProtAcc A0A8D7ZGL5
            A0A8D7ZF36
            A0A8D7ZGA2
            A0A8D7ZEX1
            A0A8D7ZEY3
            A0A8D7ZEU0
            A0A8D8EJ82
            A0A8D7ZEP4
            A0A8D7ZGB1
        UniProt_GCRP UniProtAcc G5EFJ9
        OMIM gene 152427
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Jun 2007 16:44:06 WBPerson1983 Event: Acquires_merge: WBGene00007815
      Acquires_merge: WBGene00007815
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (416)
    Legacy_information: Class 3 allele e1597sd : severe kinker little movement slight Egl; e1597/+ somewhat less severe kinker. ES3 ME0. NA2 (n500). Class 1 (loss-of-function) alleles : intragenic revertants of e1596 e.g. e1597n1212 wildtype phenotype.
      See also e1597, n500, n1211, n1212, n1213, n1214, n1215
      [Reiner D]] Mac-d (Muscle ACtivation-Defective)
      [C.elegansII] e1597sd : homozygote severe kinker, little movement; slight Egl; e1597/+ somewhat less severe kinker. Muscle activation defective(flaccid, long). Neomorphic (gf) allele.ES3 ME0. OA1 (gf): n500. Also intragenic revertants: e1597n1212spo(wildtype, probable null), e1597n1213, n500n1211 etc. OA5 (ird). [Park and Horvitz 1986a; JT; MT]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog: WBGene00061624 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039233 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00136729 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00190538 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00222745 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g4763 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1334 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g21131 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g5400 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1373 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g10526 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g3939 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g20877 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g1061 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g20901 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00051.g2635 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-103 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g11485 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold630.g20760 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01822.g23351 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07249 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_008889 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g08075 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g17993 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30000300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g7375 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00209834 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00244951 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00278424 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00261226 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292680 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0003353 Drosophila melanogaster From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040702-5 Danio rerio From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-120214-39 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070912-699 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6251 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:18862 Homo sapiens From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:18863 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1341722 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2159566 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2684139 Mus musculus From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620304 Rattus norvegicus From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621414 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621112 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00001171 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000487 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000562 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000563 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006525 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006526 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022295 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-103 encodes an ether-a-go-go-related (ERG) K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function unc-103 alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. Paper_evidence: WBPaper00000914
            WBPaper00002305
            WBPaper00005799
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 09 Feb 2011 00:00:00
      Automated_description: Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome 2 and short QT syndrome. Is an ortholog of human KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:2843
    Potential_model: DOID:0050793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6251)
      DOID:0110645 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6251)
      DOID:2843 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6251)
  Models_disease_asserted: WBDOannot00000527
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: C30D11.1:wp52
    Corresponding_transcript (19)
    Other_sequence (14)
    Associated_feature (50)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr2455
      Expr3095
      Expr3815
      Expr4896
      Expr10803
      Expr1012330
      Expr1032893
      Expr1145556
      Expr2017833
      Expr2035969
    Drives_construct (21)
    Construct_product (21)
    Microarray_results (42)
    Expression_cluster (137)
    Interaction (92)
    Anatomy_function: WBbtf0572
      WBbtf0573
      WBbtf0574
      WBbtf0575
  Map_info: Map: III Position: -3.78592 Error: 0.004728
    Well_ordered
    Positive: Positive_clone: C30D11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 862
        1079
        2799
        3603
        4091
        4458
  Reference (73)
  Remark: being swapped with mpk-1 at -4.05. was -3.93 [jah/sdm 5/99]
    klp-1 is the same gene as unc-103 and was therefore merged with this gene
  Method: Gene