WormBase Tree Display for Gene: WBGene00006805
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| WBGene00006805 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-73 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F55C7.7 | ||||||||
| Molecular_name (28) | |||||||||
| Other_name | let-509 | Person_evidence | WBPerson533 | ||||||
| CELE_F55C7.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-73 | ||||||||
| DB_info | Database | AceView | gene | 1E568 | |||||
| WormQTL | gene | WBGene00006805 | |||||||
| WormFlux | gene | WBGene00006805 | |||||||
| NDB | locus_tag | CELE_F55C7.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006805|UniProtKB=O61528 | |||||||
| family | PTHR22826 | ||||||||
| NCBI | gene | 171988 | |||||||
| RefSeq | protein | NM_001262583.3 | |||||||
| NM_001375256.3 | |||||||||
| NM_001026326.4 | |||||||||
| NM_001026327.4 | |||||||||
| NM_001026325.2 | |||||||||
| NM_001026329.7 | |||||||||
| NM_001381834.2 | |||||||||
| NM_001026328.3 | |||||||||
| NM_001262584.2 | |||||||||
| TrEMBL | UniProtAcc | H2KYM3 | |||||||
| C4ALD5 | |||||||||
| Q7JNG4 | |||||||||
| H2KYM4 | |||||||||
| O61528 | |||||||||
| H2KYM2 | |||||||||
| Q7KPP4 | |||||||||
| Q95Q51 | |||||||||
| Q7JNG6 | |||||||||
| UniProt_GCRP | UniProtAcc | O61528 | |||||||
| OMIM | gene | 601893 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Mar 2015 14:32:45 | WBPerson2970 | Event | Acquires_merge | WBGene00002701 | ||||
| Name_change | Other_name | let-509 | |||||||
| Acquires_merge | WBGene00002701 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143616 | ||||||||
| Allele (455) | |||||||||
| Legacy_information | e936 : coiler small dumpyish inactive; commissures often on wrong side; male copulatory spicules short and crumpled. ES3 ME0. NA1. | ||||||||
| [C.elegansII] e936 : coiler, small and dumpyish, inactive; commissures often on wrong side; variable defects in axon growth and fasciculation;occasional lineage defects; reduced Z migration. Male copulatory spicules short and crumpled. Synergizes with sem-5(n1779) to give Sem migration defect.ES3 ME0. OA>3: rh40, ev454::Tc1,e936je3 (intragenic change, recessive lethal and dominant suppressor of e936). See also sup-39. Cloned: 7.7 and 7.3 kb transcripts, encodes >200 kD protein related to rho-type guanine nucleotide exchange factors, yeast CDC24. [McIntire et al. 1992; Garriga and Stern 1994; NJ; JW; NW] | |||||||||
| [Howell AM] lethal | |||||||||
| [C.elegansII] h867 : leaky late larval lethal/sterile adult.OA2: h521 (leaky sterile adult), h522. [Howell and Rose 1990; KR] | |||||||||
| Strain (25) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (42) | |||||||||
| Ortholog (60) | |||||||||
| Paralog | WBGene00006496 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006887 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009337 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010111 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010776 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015704 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-73 encodes a guanine nucleotide exchange factor (GNEF) similar to the Trio protein; UNC-73 is required for vulval morphogenesis, for the migration of QL, QR, CAN, and hypodermal P cells, the commissure outgrowth of D type motoneurons, and amphid axon outgrowth; UNC-73 has GNEF activity for both CED-10 and MIG-2 in vitro; the requirement for UNC-73 in P cell migration can be suppressed by transgenic overexpression of rho-1; UNC-73 activates several small GTPases: RHO-1 in P cell migration, and both CED-10 and MIG-2 in vulval morphogenesis, P cell migration, and axon outgrowth. | Paper_evidence | WBPaper00002978 | |||||
| WBPaper00004437 | |||||||||
| WBPaper00004959 | |||||||||
| WBPaper00005104 | |||||||||
| WBPaper00005495 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including cellular component organization; modulation of chemical synaptic transmission; and positive regulation of protein localization to synapse. Located in axon; cytoplasm; and muscle cell projection. Expressed in several structures, including egg-laying apparatus; hermaphrodite gonad; lumbar ganglion; neurons; and tail hypodermis. Used to study epilepsy. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 44; and cerebral infarction. Is an ortholog of human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
| Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12303) | |||||
| DOID:0070074 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12303) | ||||||
| DOID:12720 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4814) | ||||||
| DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4814) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4814) | ||||||
| Models_disease_asserted | WBDOannot00000553 | ||||||||
| WBDOannot00000554 | |||||||||
| Molecular_info | Corresponding_CDS | F55C7.7a | |||||||
| F55C7.7b | |||||||||
| F55C7.7c | |||||||||
| F55C7.7d | |||||||||
| F55C7.7e | |||||||||
| F55C7.7f | |||||||||
| F55C7.7g | |||||||||
| F55C7.7h | |||||||||
| F55C7.7i | |||||||||
| Corresponding_CDS_history | F55C7.7e:wp93 | ||||||||
| F55C7.7f:wp199 | |||||||||
| F55C7.7f:wp273 | |||||||||
| Corresponding_transcript | F55C7.7a.1 | ||||||||
| F55C7.7b.1 | |||||||||
| F55C7.7c.1 | |||||||||
| F55C7.7d.1 | |||||||||
| F55C7.7e.1 | |||||||||
| F55C7.7f.1 | |||||||||
| F55C7.7g.1 | |||||||||
| F55C7.7h.1 | |||||||||
| F55C7.7i.1 | |||||||||
| F55C7.7i.2 | |||||||||
| Other_sequence (58) | |||||||||
| Associated_feature (65) | |||||||||
| Experimental_info (9) | |||||||||
| Map_info | Map | I | Position | -1.87882 | Error | 0.020891 | |||
| Well_ordered | |||||||||
| Hide_under | WBGene00002703 | ||||||||
| Positive | Inside_rearr | sDf4 | |||||||
| Positive_clone | F55C7 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| NW#123 | |||||||||
| Mapping_data | 2_point | 6 | |||||||
| 3200 | |||||||||
| 6045 | |||||||||
| Multi_point (15) | |||||||||
| Pos_neg_data (21) | |||||||||
| Reference (240) | |||||||||
| Method | Gene |
